Association of the ADH2*3 allele with greater alcohol expectancies in African-American young adults

Journal of Studies on Alcohol

Volumn 64, Issue 2, 2003, Pages 176-181

  Ehlers, Cindy L ^a   Carr, Lucinda ^a,b   Betancourt, Michelle ^a   Montane Jaime, Karelia ^a,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ADH1C PROTEIN, HUMAN;

ADULT; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MALE; NEGRO; PATHOGENESIS; POPULATION RESEARCH; AFRICAN AMERICAN; ALLELE; GENETICS;

ADULT; AFRICAN AMERICANS; ALCOHOL DEHYDROGENASE; ALCOHOLISM; ALLELES; FEMALE; GENOTYPE; HUMANS; MALE;

EID: 0037360396     PISSN: 0096882X     EISSN: None     Source Type: Journal    
DOI: 10.15288/jsa.2003.64.176     Document Type: Article

References (61)

1. AMERICAN PSYCHIATRIC ASSOCIATION. Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R), Washington, DC, 1987.
2. BORRAS, E., COUTELLE, C., ROSELL, A., FERNANDEZ-MUIXI, F., BROCH, M., CROSAS, B., HJELMQVIST, L., LORENZO, A., GUTIERREZ, C., SANTOS, M., SZCZEPANEK, M., HEILIG, M., QUATTROCCHI, P., FARRES, J., VIDAL, F., RICHART, C., MACH, T., BOGDAL, J., JORNVALL, H., SEITZ, H.K., COUZIGOU, P. AND PARES, X. Genetic polymorphism of alcohol dehydrogenase in Europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology 31: 984-989, 2000.
3. BOSRON, W.F. AND LI, T.-K. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6: 502-510, 1986.
4. BOSRON, W.F., EHRIG, T. AND LI, T.-K. Genetic factors in alcohol metabolism and alcoholism. Semin. Liver Dis. 13: 126-135, 1993.
5. BROWN, G.L., ALBAUGH, B.J., ALBAUGH, R.W., GOODSON, S.G., TRUNZO, M., WYNNE, D.K. AND GOLDMAN, D. Alcoholism and substance abuse among selected southern Cheyenne Indians. Cult. Med. Psychiat. 16: 531-542, 1993.
6. BROWN, S.A., CHRISTIANSEN, B.A. AND GOLDMAN, M.S. The Alcohol Expectancy Questionnaire: An instrument for the assessment of adolescent and adult alcohol expectancies. J. Stud. Alcohol 48: 483-491, 1987a.
7. BROWN, S.A., CREAMER, V.A. AND STETSON, B.A. Adolescent alcohol expectancies in relation to personal and parental drinking patterns. J. Abnorm. Psychol. 96: 117-121, 1987b.
8. BROWN, S.A., GOLDMAN, M.S., INN, A. AND ANDERSON, L.R. Expectations of reinforcement from alcohol: Their domain and relation to drinking patterns. J. Cons. Clin. Psychol. 48: 419-426, 1980.
9. BUCHOLZ, K.K., CADORET, R., CLONINGER, C.R., DINWIDDIE, S.H., HESSELBROCK, V.M., NURNBERGER, J.I., JR., REICH, T., SCHMIDT, I. AND SCHUCKIT, M.A. A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. J. Stud. Alcohol 55: 149-158, 1994.
10. CHRISTIANSEN, B.A. AND GOLDMAN, M.S. Alcohol related expectancies versus demographic/background variables in the prediction of adolescent drinking. J. Cons. Clin. Psychol. 51: 249-257, 1983.
11. COUZIGOU, P., FLEURY, B., GROPPI, A., IRON, A., COUTELLE, C., CASSAIGNE, A. AND BEGUERET, J. Role of alcohol dehydrogenase polymorphism in ethanol metabolism and alcohol-related diseases. Adv. Exp. Med. Biol. 284: 263-270, 1991.
12. CRABB, D.W. Ethanol oxidizing enzymes: Roles in alcohol metabolism and alcoholic liver disease. Prog. Liver Dis. 13: 151-172, 1995.
13. DEVOR, E.J. AND CLONINGER, C.R. Genetics of alcoholism. Ann. Rev. Genet. 23: 19-36, 1989.
14. EHLERS, C.L. GILDER, D.A., HARRIS, L. AND CARR, L. Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. Alcsm Clin. Exp. Res. 25: 1773-1777, 2001.
15. EHLERS, C.L. AND SCHUCKIT, M.A. EEG fast frequency activity in the sons of alcoholics. Biol. Psychiat. 27: 631-641, 1990.
16. EHLERS, C.L. AND SCHUCKIT, M.A. Evaluation of EEG alpha activity in sons of alcoholics. Neuropsychopharmacology 4: 199-205, 1991.
17. GARCIA-ANDRADE, C., WALL, T.L. AND EHLERS, C.L. Alcohol expectancies in a Native American population. Alcsm Clin. Exp. Res. 20: 1438-1442, 1996.
18. GOLDMAN, D. Genetic transmission. In: GALANTER, M. (Ed.) Recent Developments in Alcoholism, Vol. 11: Ten Years of Progress, New York: Plenum Press, 1993, pp. 231-248.
19. HESSELBROCK, M., EASTON, C., BUCHOLZ, K.K., SCHUCKIT, M. AND HESSELBROCK, V. A validity study of the SSAGA: A comparison with the SCAN. Addiction 94: 1361-1370, 1999.
20. HESSELBROCK, V.M., O'BRIEN, J., WEINSTEIN, M. AND CARTER-MENENDEZ, N. Reasons for drinking and alcohol use in young adults at high and at low risk for alcoholism. Brit. J. Addict. 82: 1335-1339, 1987.
21. HIGUCHI, S., MATSUSHITA, S., MURAYAMA, M., TAKAGI, S. AND HAYASHIDA, M. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Amer. J. Psychiat. 152: 1219-1221, 1995.
22. JOHNSON, R.C., NAGOSHI, C.T., DANKO, G.P., HONBO, K.A. AND CHAU, L.L. Familial transmission of alcohol use norms and expectancies and reported alcohol use. Alcsm Clin. Exp. Res. 14: 216-220, 1990.
23. JORNVALL, H. AND HOOG, J.O. Nomenclature of alcohol dehydrogenases. Alcohol Alcsm 30: 153-161, 1995.
24. KAPLAN, R.F., HESSELBROCK, V.M., O'CONNOR, S. AND DEPALMA, N. Behavioral and EEG responses to alcohol in nonalcoholic men with a family history of alcoholism. Prog. Neuropychopharmacol. Biol. Psychiat. 12: 873-885, 1988.
25. LEIGH, B.C. Attitudes and expectancies as predictors of drinking habits: A comparison of three scales. J. Stud. Alcohol 50: 432-440, 1989.
26. LEX, B.W., LUKAS, S.E., GREENWALD, N.E. AND MENDELSON, J.H. Alcohol-induced changes in body sway in women at risk for alcoholism: A pilot study. J. Stud. Alcohol 49: 346-356, 1988.
27. LONG, J.C., KNOWLER, W.C., HANSON, R.L., ROBIN, R.W., URBANEK, M., MOORE, E., BENNETT, P.H. AND GOLDMAN, D. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Amer. J. Med. Genet. 81: 216-221, 1998.
28. McCARVER, D.G. ADH2 and CYP2E1 genetic polymorphisms: Risk factors for alcohol-related birth defects. Drug Metab. Disposit. 29 (4 Pt 2): 562-565, 2001.
29. McCARVER, D.G., THOMASSON, H.R., MARTIER, S.S., SOKOL, R.J. AND LI, T.-K. Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African-Americans. J. Pharmacol. Exp. Therapeut. 283: 1095-1101, 1997.
30. MANN, L.M., CHASSIN, L. AND SHER, K.J. Alcohol expectancies and the risk for alcoholism. J. Cons. Clin. Psychol. 55: 411-417, 1987.
31. MARSHALL, S.J. AND CHAMBERS, G.K. Alcohol dehydrogenase and aldehyde dehydrogenase gene variants in New Zealand alcoholic patients (abstract). Alcsm Clin. Exp. Res. 18 (2): 58A, 1994.
32. MORZORATI, S.L., RAMCHANDANI, V.A., FLURY, L., LI, T.-K. AND O'CONNOR, S. Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant Alcsm Clin. Exp. Res. 26: 1299-1306, 2002.
33. MOSS, H.B., YAO, J.K. AND MADDOCK, J.M. Responses by sons of alcoholic fathers to alcoholic and placebo drinks: Perceived mood, intoxication, and plasma prolactin. Alcsm Clin. Exp. Res. 13: 252-257, 1989.
34. MULLIGAN RAUCH, S.A. AND BRYANT, J.B. Gender and context differences in alcohol expectancies. J. Social Psychol. 140: 240-253, 2000.
35. NEUMARK, Y.D., FRIEDLANDER, Y., THOMASSON, H.R. AND LI, T.-K. Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: A pilot study. J. Stud. Alcohol 59: 133-139, 1998.
36. O'MALLEY, S.S. AND MAISTO, S.S. Effects of family drinking history and expectancies on responses to alcohol in men. J. Stud. Alcohol 46: 289-297, 1985.
37. OSIER, M., PAKSTIS, A.J., KIDD, J.R., LEE, J.-F., YIN, S.-J., KO, H.-C., EDENBERG, H.J., LU, R.-B. AND KIDD, K.K. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Amer. J. Human Genet. 64: 1147-1157, 1999.
38. PARES, X., MORENO, A., FARRES, J., SOLER, X., PANES, J., PARES, A. AND CABALLERIA, J. Liver and stomach alcohol dehydrogenase in normal and alcoholic individuals from Barcelona. Paper presented at the Pro ISBRA Satellite Symposium: Genetics and Alcohol Related Diseases, Bordeaux, France, June 18-19, 1992.
39. REICH, T., EDENBERG, H.J., GOATE, A., WILLIAM, J.T., RICE, J.P., VAN EERDEWEGH, P., FOROUD, T., HESSELBROCK, V., SCHUCKIT, M.A., BUCHOLZ, K., PORJESZ, B., LI, T.-K., CONNEALLY, P.M., NURNBERGER, J.I., JR., TISCHFIELD, J.A., CROWE, R.R., CLONINGER, C.R., WU, W., SHEARS, S., CARR, K., CROSE, C., WILLIG, C. AND BEGLEITER, H. Genome-wide search for genes affecting the risk for alcohol dependence. Amer. J. Med. Genet. 81: 207-215, 1998.
40. ROHSENOW, D.J. Drinking habits and expectancies about alcohol's effects for self versus others. J. Cons. Clin. Psychol. 51: 752-756, 1983.
41. SCHUCKIT, M.A. Self-rating of alcohol intoxication by young men with and without family histories of alcoholism. J. Stud. Alcohol 41: 242-249, 1980.
42. SCHUCKIT, M.A. Subjective responses to alcohol in sons of alcoholics and control subjects. Arch. Gen. Psychiat. 41: 879-884, 1984.
43. SCHUCKIT, M.A. Genetics and the risk for alcoholism. JAMA 254: 2614-2617, 1985.
44. SCHUCKIT, M.A., GOLD, E.O., CROOT, K., FINN, P. AND POLICH, J. P300 latency after ethanol ingestion in sons of alcoholics and in controls. Biol. Psychiat. 24: 310-315, 1988.
45. SCHUCKIT, M.A., GOLD, E. AND RISCH, C. Plasma cortisol levels following ethanol in sons of alcoholics and controls. Arch. Gen. Psychiat. 44: 942-945, 1987.
46. SCHUCKIT, M.A., PARKER, D.C., AND ROSSMAN, L.R. Ethanol-related prolactin responses and risk for alcoholism. Biol. Psychiat. 18: 1153-1159, 1983.
47. SCHUCKIT, M.A. AND SMITH, T.L. An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch. Gen. Psychiat. 53: 202-210, 1996.
48. SHER, K.J., WALITZER, K.S., WOOD, P.K. AND BRENT, E.E. Characteristics of children of alcoholics: Putative risk factors, substance use and abuse, and psychopathology. J. Abnorm. Psychol. 100: 427-448, 1991.
49. SMITH, G.T., GOLDMAN, M.S., GREENBAUM, P.E. AND CHRISTIANSEN, B.A. Expectancy for social facilitation from drinking: The divergent paths of high-expectancy and low-expectancy adolescents. J. Abnorm. Psychol. 104: 32-40, 1995.
50. SOUTHWICK, L.L., STEELE, C.M., MARLATT, G.A. AND LINDELL, M.K. Alcohol-related expectancies: Defined by phase of intoxication and drinking experience. J. Cons. Clin. Psychol. 49: 713-721, 1981.
51. SUN, F., TSURITANI, I., HONDA, R., MA, Z.-Y. AND YAMADA, Y. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Human Genet. 105: 295-300, 1999.
52. TAKESHITA, T., MORIMOTO, K., MAO, X., HASHIMOTO, T. AND FURUYAMA, J. Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. Human Genet. 94: 217-223, 1994.
53. THOMASSON, H.R., BEARD, J.D. AND LI, T.-K. ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcsm Clin. Exp. Res. 19: 1494-1499, 1995.
54. THOMASSON, H.R., CRABB, D.W., EDENBERG, H.J., LI, T.-K., HWU, H.-G., CHEN, C.-C., YEH, E.-K. AND YIN, S.-J. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcsm Clin. Exp. Res. 18: 640-643, 1994.
55. THOMASSON, H.R., EDENBERG, H.J., CRABB, D.W., MAI, X.-L., JEROME, R.E., LI, T.-K., WANG, S.-P., LIN, Y.-T., LU, R.-B. AND YIN, S.-J. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Amer. J. Human Genet. 48: 677-681, 1991.
56. WALL, T.L., CARR, L.G. AND EHLERS, C.L. Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. Amer. J. Psychiat. 160: 41-46, 2003.
57. WALL, T.L., GALLEN, C.C. AND EHLERS, C.L. Effects of alcohol on the EEG in Asian men with genetic variations of ALDH2. Biol. Psychiat. 34 (1-2): 91-99, 1993.
58. WALL, T.L., GARCIA-ANDRADE, C., THOMASSON, H.R. AND EHLERS, C.L. Alcohol dehydrogenase polymorphisms in Native Americans: Identification of the ADH2*3 allele. Alcohol Alcsm 32: 129-132, 1997.
59. WALL, T.L., THOMASSON, H.R., SCHUCKIT, M.A. AND EHLERS, C.L. Subjective feelings of alcohol intoxication in Asians with genetic variations of ALDH2 alleles. Alcsm Clin. Exp. Res. 16: 991-999, 1992.
60. WHITFIELD, J.B. Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. Alcohol Alcsm 32: 613-619, 1997.
61. XU, Y.L., CARR, L.G., BOSRON, W.F., LI, T.-K. AND EDENBERG, H.J. Genotyping of human alcohol dehydrogenase at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2: 209-214, 1988.