Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice

Journal of Neuroscience

Volumn 28, Issue 9, 2008, Pages 2231-2241

  Yang, Peng ^a   Arnold, Sheila A ^a   Habas, Agata ^a   Hetman, Michal ^a   Hagg, Theo ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Astrocyte; Dopaminergic; Neuroblast; Quinpirole; Subgranular zone; Subventricular zone

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; DOPAMINE 2 RECEPTOR; ETICLOPRIDE; MESSENGER RNA; QUINPIROLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HIPPOCAMPUS; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; STRIATONIGRAL DEGENERATION;

ANIMALS; ANTIBODIES; BROMODEOXYURIDINE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CILIARY NEUROTROPHIC FACTOR; COCULTURE TECHNIQUES; DOPAMINE AGONISTS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; LATERAL VENTRICLES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROGLIA; NEURONS; OXIDOPAMINE; QUINPIROLE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RNA, MESSENGER;

EID: 39849100457     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3574-07.2008     Document Type: Article

References (52)

1. Agnati LF, Zoli M, Stromberg I, Fuxe K (1995) Intercellular communication in the brain: wiring versus volume transmission. Neuroscience 69:711-726.
2. Albrecht PJ, Murtie JC, Ness JK, Redwine JM, Enterline JR, Armstrong RC, Levison SW (2003) Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production. Neurobiol Dis 13:89-101.
3. Alvarez-Buylla A, Lim DA (2004) For the long run: maintaining germinal niches in the adult brain. Neuron 41:683-686.
4. Araki KY, Sims JR, Bhide PC (2007) Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during preand postnatal development. Brain Res 1156:31-45.
5. Baker SA, Baker KA, Hagg T (2004) Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Eur J Neurosci 20:575-579.
6. Baker SA, Baker KA, Hagg T (2005) D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult mice. Neurobiol Disease 18:523-527.
7. Bal A, Bachelot T, Savasta M, Manier M, Verna JM, Benabid AL, Feuerstein C (1994) Evidence for dopamine D2 receptor mRNA expression by striatal astrocytes in culture: in situ hybridization and polymerase chain reaction studies. Brain Res Mol Brain Res 23:204-212.
8. Brock JW, Farooqui S, Ross K, Prasad C (1992) Localization of dopamine D2 receptor protein in rat brain using polyclonal antibody. Brain Res 578:244-250.
9. Carroll P, Sendtner M, Meyer M, Thoenen H (1993) Rat ciliary neurotrophic factor (CNTF): gene structure and regulation of mRNA levels in glial cell cultures. Glia 9:176-187.
10. Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S (2003) Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. J Neurosci 23:1730-1741.
11. Cory-Slechta DA, Zuch CL, Fox RA (1996) Comparison of the stimulus properties of a pre- vs. a putative postsynaptic dose of quinpirole. Pharmacol Biochem Behav 55:423-432.
12. Dall'olio R, Rimondini R, Gandolfi O (1997) Effects of competitive and non-competitive NMDA receptor antagonists on behavioral responses induced by 7-OH-DPAT and quinpirole in rats. Pharmacol Res 36:203-209.
13. Dobrea GM, Unnerstall JR, Rao MS (1992) The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat. Brain Res Dev Brain Res 66:209-219.
14. Doetsch F, Garcia-Verdugo JM, Alvarez-Buylla A (1997) Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17:5046-5061.
15. Emery B, Merson TD, Snell C, Young KM, Ernst M, Kilpatrick TJ (2006) SOCS3 negatively regulates LIF signaling in neural precursor cells. Mol Cell Neurosci 31:739-747.
16. Emsley JG, Hagg T (2003) Endogenous and exogenous ciliary neurotrophic factor enhances forebrain neurogenesis in adult mice. Exp Neurol 183:298-310.
17. Enwere E, Shingo T, Gregg C, Fujikawa H, Ohta S, Weiss S (2004) Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J Neurosci 24:8354-8365.
18. Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV (2004) GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci 7:1233-1241.
19. Hagg T (2005) Molecular regulation of adult CNS neurogenesis: an integrated view. Trends Neurosci 28:589-595.
20. Hagg T, Varon S (1993) Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc Natl Acad Sci USA 90:6315-6319.
21. Hall H, Kohler C, Gawell L (1985) Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain. Eur J Pharmacol 111:191-199.
22. Hitoshi S, Seaberg RM, Koscik C, Alexson T, Kusunoki S, Kanazawa I, Tsuji S, van der Kooy D (2004) Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev 18:1806-1811.
23. Hoglinger GU, Rizk P, Muriel MP, Duyckaerts C, Oertel WH, Caille I, Hirsch EC (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci 7:726-735.
24. Ip NY (1998) The neurotrophins and neuropoietic cytokines: two families of growth factors acting on neural and hematopoietic cells. Ann NY Acad Sci 840:97-106.
25. Ip NY, Wiegand SJ, Morse J, Rudge JS (1993) Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur J Neurosci 5:25-33.
26. Khan ZU, Koulen P, Rubinstein M, Grandy DK, Goldman-Rakic PS (2001) An astroglia-linked dopamine D2-receptor action in prefrontal cortex. Proc Natl Acad Sci USA 98:1964-1969.
27. Kippin TE, Kapur S, van der Kooy D (2005) Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. J Neurosci 25:5815-5823.
28. Klockgether T (2004) Parkinson's disease: clinical aspects. Cell Tissue Res 318:115-120.
29. Lee MY, Deller T, Kirsch M, Frotscher M, Hofmann HD (1997) Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor α expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion. J Neurosci 17:1137-1146.
30. Lie DC, Song H, Colamarino SA, Ming GL, Gage FH (2004) Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol 44:399-421.
31. Lindvall O, Kokaia Z (2006) Stem cells for the treatment of neurological disorders. Nature 441:1094-1096.
32. Ming GL, Song H (2005) Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 28:223-250.
33. Mizisin AP, Calcutt NA, DiStefano PS, Acheson A, Longo FM (1997) Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats. Diabetes 46:647-652.
34. Ohtani N, Goto T, Waeber C, Bhide PG (2003) Dopamine modulates cell cycle in the lateral ganglionic eminence. J Neurosci 23:2840-2850.
35. Park CK, Ju WK, Hofmann HD, Kirsch M, Ki Kang J, Chun MH, Lee MY (2000) Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus following transient global ischemia. Brain Res 861:345-353.
36. Rudge JS, Morrissey D, Lindsay RM, Pasnikowski EM (1994) Regulation of ciliary neurotrophic factor in cultured rat hippocampal astrocytes. Eur J Neurosci 6:218-229.
37. Rudge JS, Pasnikowski EM, Holst P, Lindsay RM (1995) Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid. J Neurosci 15:6856-6867.
38. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
39. 2 receptor-like immunoreactivity in midbrain dopaminergic neurons and their striatal targets. J Neurosci 14:88-106.
40. Shimazaki T, Shingo T, Weiss S (2001) The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J Neurosci 21:7642-7653.
41. Snyder EY, Daley GQ, Goodell M (2004) Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res 76:157-168.
42. Song H, Stevens CF, Gage FH (2002) Astroglia induce neurogenesis from adult neural stem cells. Nature 417:39-44.
43. Stockli KA, Lottspeich F, Sendtner M, Masiakowski P, Carroll P, Gotz R, Lindholm D, Thoenen H (1989) Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature 342:920-923.
44. Stockli KA, Lillien LE, Naher-Noe M, Breitfeld G, Hughes RA, Raff MC, Thoenen H, Sendtner M (1991) Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. J Cell Biol 115:447-459.
45. Suslov ON, Kukekov VG, Ignatova TN, Steindler DA (2002) Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres. Proc Natl Acad Sci USA 99:14506-14511.
46. Swanson LW (1982) The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. Brain Res Bull 9:321-353.
47. Takahashi R, Yokoji H, Misawa H, Hayashi M, Hu J, Deguchi T (1994) A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet 7:79-84.
48. Thoenen H, Sendtner M (2002) Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat Neurosci 5:1046-1050.
49. Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, et al. (2003) High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21:652-659.
50. Vallar L, Meldolesi J (1989) Mechanisms of signal transduction at the dopamine D2 receptor. Trends Pharmacol Sci 10:74-77.
51. Wolf E, Kramer R, Polejaeva I, Thoenen H, Brem G (1994) Efficient generation of chimaeric mice using embryonic stem cells after long-term culture in the presence of ciliary neurotrophic factor. Transgenic Res 3:152-158.
52. Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN (2003) Gene expression in human neural stem cells: effects of leukemia inhibitory factor. J Neurochem 86:179-195.