메뉴 건너뛰기




Volumn 18, Issue 5, 2008, Pages 1702-1707

2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924

Author keywords

Anticancer agent; Benzimidazole; Haloimidazole; Halopyrazole; IGF 1R; Tyrosine kinases

Indexed keywords

ANTINEOPLASTIC AGENT; BMS 536924; IMIDAZOLE DERIVATIVE; PROTEIN INHIBITOR; PYRAZOLE DERIVATIVE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

EID: 39849091962     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.049     Document Type: Article
Times cited : (21)

References (30)
  • 1
    • 33744493376 scopus 로고    scopus 로고
    • (a) J. Baselga Science 312 2006 1175
    • (2006) Science , vol.312 , pp. 1175
    • Baselga, J.1
  • 6
    • 13644269949 scopus 로고    scopus 로고
    • Another key signaling pathway which can be activated by IGF-1 and IGF-2 is the Wnt pathway, which regulates the key transcription factor, β-catenin. Signaling though IGF-1R (via PI3K/AKT) can activate Wnt signaling through GSK-3β inhibition. GSK-3β is a key component in the degradation of β-catenin, and therefore in the maintenance of the ‘normal’ state. See M. Illyas J. Pathol. 205 2005 130
    • (2005) J. Pathol. , vol.205 , pp. 130
    • Illyas, M.1
  • 7
    • 29644442524 scopus 로고    scopus 로고
    • The combination of a PI3K/AKT pathway inhibitor and doxorubicin represent an effective strategy for treating tumor cells in which the PI3K/AKT pathway is constitutively activated and the p53 pathway is functional. See Y. Fujiwara K. Kawada D. Takano S. Tanimura K. Ozaki M. Kohno Biochem. Biophys. Res. Commun. 340 2006 560
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 560
    • Fujiwara, Y.1    Kawada, K.2    Takano, D.3    Tanimura, S.4    Ozaki, K.5    Kohno, M.6
  • 8
    • 32944461233 scopus 로고    scopus 로고
    • There is evidence that antidiabetic drugs, such as the PPARγ agonist thiazolidinedione, rosiglitazone, suppress IGF-1 tumor-promoting activity. See G. He Y.M. Sung J. DiGiovanni S.M. Fischer Cancer Res. 66 2006 1873
    • (2006) Cancer Res. , vol.66 , pp. 1873
    • He, G.1    Sung, Y.M.2    DiGiovanni, J.3    Fischer, S.M.4
  • 26
    • 0142092249 scopus 로고    scopus 로고
    • (a) For relevant references for such Cu(I)-catalyzed coupling reactions, see Y.-J. Wu H. He Synlett 12 2003 1789
    • (2003) Synlett , vol.12 , pp. 1789
    • Wu, Y.-J.1    He, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.