A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death

Journal of Neurochemistry

Volumn 104, Issue 6, 2008, Pages 1565-1576

  Sato, Yoshiaki ^a,b   Nakanishi, Keiko ^a   Tokita, Yoshihito ^a   Kakizawa, Hiroko ^a,b   Ida, Michiru ^a   Maeda, Hiroshi ^c   Matsui, Fumiko ^a   Aono, Sachiko ^a   Saito, Akiko ^a,b   Kuroda, Yoshiyuki ^a   Hayakawa, Masahiro ^d   Kojima, Seiji ^b   Oohira, Atsuhiko ^a  

^a INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c SEIKAGAKU CORPORATION   (Japan)

^d NAGOYA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Caspase 3; Chondroitin sulfate; Excitotoxicity; Glutamate receptor; Neuronal death; Neuroprotection

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID; CASPASE 3; CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; CHONDROITIN SULFATE; CHONDROITIN SULFATE D; CHONDROITIN SULFATE E; DERMATAN SULFATE; DEXTRAN SULFATE; GLUTAMATE RECEPTOR; GLUTAMIC ACID DERIVATIVE; HEPARIN; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCITOTOXICITY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CASPASE 3; CELL DEATH; CELL SURVIVAL; CHONDROITIN SULFATES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; FEMALE; KAINIC ACID; MEMBRANE POTENTIALS; N-METHYLASPARTATE; NEOCORTEX; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PHOSPHORYLATION; POLYMERS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE;

EID: 39849091490     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05107.x     Document Type: Article

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