Fab MOR03268 Triggers Absorption Shift of a Diagnostic Dye via Packaging in a Solvent-shielded Fab Dimer Interface

Journal of Molecular Biology

Volumn 377, Issue 1, 2008, Pages 206-219

  Hillig, Roman C ^a   Urlinger, Stefanie ^b   Fanghänel, Jörg ^a   Brocks, Bodo ^b   Haenel, Cornelia ^b   Stark, Yvonne ^b   Sülzle, Detlev ^a   Svergun, Dmitri I ^c,d   Baesler, Siegfried ^a   Malawski, Guido ^a   Moosmayer, Dieter ^a   Menrad, Andreas ^a   Schirner, Michael ^a   Licha, Kai ^a  

^a BAYER PHARMA AG   (Germany)

^b MORPHOSYS AG   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY   (Russian Federation)

Author keywords

crystal structure; cyanine dye; diagnostic imaging; isothermal titration calorimetry; small angle X ray scattering

Indexed keywords

CONTRAST MEDIUM; IMMUNOGLOBULIN F(AB) FRAGMENT; MOR03268 ANTIBODY; TETRASULFOCYANINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE SPECTROSCOPY; GEL FILTRATION; MICROCALORIMETRY; MOLECULAR INTERACTION; NEAR INFRARED SPECTROSCOPY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

EID: 39749182082     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.12.071     Document Type: Article

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