CT Colonography: Current Status and Future Promise

Gastroenterology Clinics of North America

Volumn 37, Issue 1, 2008, Pages 161-189

  Summerton, Susan ^a,b   Little, Elizabeth ^a   Cappell, Mitchell S ^c  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIUM; GLUCAGON; SPASMOLYTIC AGENT;

CANCER SCINTISCANNING; CANCER SCREENING; CLEANING; COLON; COLON CANCER; COLON DILATATION; COLON POLYP; COMPUTED TOMOGRAPHIC COLONOGRAPHY; DIAGNOSTIC ACCURACY; HISTOLOGY; HUMAN; IMAGE QUALITY; IMAGING; MASS SCREENING; PATHOGENESIS; PATIENT ATTITUDE; PATIENT REFERRAL; RADIATION EXPOSURE; RADIOLOGY; REVIEW; SAFETY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL IMAGING; TREATMENT CONTRAINDICATION; TREATMENT INDICATION;

COLONOGRAPHY, COMPUTED TOMOGRAPHIC; COLORECTAL NEOPLASMS; EUROPE; HUMANS; REPRODUCIBILITY OF RESULTS; UNITED STATES;

EID: 39749181868     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gtc.2007.12.016     Document Type: Review

References (118)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2007. CA Cancer J Clin 57 (2007) 43-66
2. Mandel J.S. Screening of patients at average risk for colon cancer. Med Clin North Am 89 (2005) 43-59
3. Cappell M.S. From colonic polyps to colon cancer: pathophysiology, clinical presentation, and diagnosis. Clin Lab Med 25 (2005) 135-177
4. Leslie A., Carey F.A., Pratt N.R., et al. The colorectal adenoma-carcinoma sequence. Br J Surg 89 (2002) 845-860
5. Winawer S., Fletcher R., Rex D., et al. Colorectal cancer screening and surveillance: clinical guidelines and rationale-update based on new evidence. Gastroenterology 124 (2003) 544-560
6. Seeff L.C., Nadel M.R., Klabunde C., et al. Patterns and predictors of colorectal cancer test use in the adult population. Cancer 100 (2004) 2093-2103
7. Colorectal cancer test use among persons aged > or = 50 years-United States 2001. MMWR Morb Mortal Wkly Rep 52 (2004) 193-196
8. Harewood G.C., Wiersema M.J., and Melton III L.J. A prospective, controlled assessment of factors influencing acceptance of screening colonoscopy. Am J Gastroenterol 97 (2002) 3186-3194
9. Morson B.C., and Dawson I.M.P. Gastrointestinal pathology (1972), Blackwell Scientific, Oxford (UK)
10. Heald R.J., and Bussey H.J.R. Clinical experiences at St. Mark's Hospital with multiple synchronous cancers of the colon and rectum. Dis Colon Rectum 18 (1975) 6-10
11. Day D.W., and Morson B.C. The adenomatous-carcinoma sequence. In: Morson B.C. (Ed). The pathogenesis of colon cancer (1978), WB Saunders, Philadelphia 58-71
12. Cappell M.S. The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps. Med Clin North Am 89 (2005) 1-42
13. Stryker S.J., Wolff B.G., Culp C.E., et al. Natural history of untreated colonic polyps. Gastroenterology 93 (1987) 1009-1013
14. Bussey H.J.R. Familial polyposis coli: family studies, histopathology, differential diagnosis and results of treatment (1975), Johns Hopkins University Press, Baltimore (MD)
15. Miyaki M., Knoishi M., Kikuchi-Yanoshita R., et al. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 54 (1994) 3011-3020
16. Robbins D.H., and Itzkowitz S.H. The molecular and genetic basis of colon cancer. Med Clin North Am 86 (2002) 1467-1495
17. Appel M.F. Nature and significance of colonic polyps. South Med J 70 (1977) 1213-1214
18. Gebbers J.O., and Laissue J.A. Mixed hyperplastic and neoplastic polyp of the colon: an immunohistological study. Virchows Arch A Pathol Anat Histopathol 410 (1986) 189-194
19. Urbanski S.J., Kossakowska A.E., Marcon N., et al. Mixed hyperplastic adenomatous polyps: an underdiagnosed entity-report of a case of adenocarcinoma within a mixed hyperplastic adenomatous polyp. Am J Surg Pathol 8 (1984) 551-556
20. Cappell M.S., and Forde K.A. Spatial clustering of multiple hyperplastic, adenomatous, and malignant colonic polyps in individual patients. Dis Colon Rectum 32 (1989) 641-652
21. Rubio C.A., Stemme S., Jaramillo E., et al. Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy 38 (2006) 266-270
22. Young J.P., Jenkins M.A., Parry S., et al. Serrated pathway colorectal cancer in the population: genetic consideration. Gut 56 (2007) 1453-1459
23. Lynch H.T., and de la Chapelle A. Hereditary colon cancer. N Engl J Med 348 (2003) 919-932
24. Winawer S.J., Zauber A.G., Ho M.N., et al. Prevention of colorectal cancer by colonoscopic polypectomy. N Engl J Med 329 (1993) 1977-1981
25. U.S. Census Bureau. Census 2000 Table PHC-T-9. Population by age, sex, race, and Hispanic or Latino origin for the United States. 2000. Available at: www.census.gov/population/www/cen2000/phc-t9.html. Accessed July 4, 2007.
26. Imperiale T.F., Ransohoff D.F., Itzkowitz S.H., et al. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med 351 (2004) 2704-2714
27. Allison J.E. Colon cancer screening guidelines 2005: the fecal occult blood test option has become a better FIT. Gastroenterology 125 (2005) 745-748
28. Levin T.R. Flexible sigmoidoscopy for colorectal cancer screening: valid approach or short sighted?. Gastroenterol Clin North Am 31 (2002) 1015-1029
29. Lieberman D.A., Weiss D.G., and Veterans Affairs Cooperative Study Group 380. One-time screening for colorectal cancer with combined fecal occult-blood testing and examination of the distal colon. N Engl J Med 345 (2001) 555-560
30. Petko Z., Ghiassi M., Shuber A., et al. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res 11 (2005) 1203-1209
31. Winawer S.J., Stewart E.T., Zauber A.G., et al. A comparison of colonoscopy and double-contrast barium enema for surveillance after polypectomy: National Polyp Study Work Group. N Engl J Med 342 (2000) 1766-1772
32. Cappell M.S., and Friedel D. The role of sigmoidoscopy and colonoscopy in the diagnosis and management of lower gastrointestinal disorders: technique, indications, and contraindications. Med Clin North Am 86 (2002) 1217-1252
33. Fidler J.L., Johnson C.D., MacCarty R.L., et al. Detection of flat lesions in the colon with CT colonography. Abdom Imaging 27 (2002) 292-300
34. Ahlquist D.A., and Shuber A.P. Stool screening for colorectal cancer: evolution from occult blood to molecular markers. Clin Chim Acta 315 (2002) 157-168
35. Vining DJ, Gelfand DW. Non-invasive colonoscopy using helical CT scanning, 3D reconstruction and virtual reality. Presented in the syllabus of the 23rd annual meeting, Society of Gastrointestinal Radiologists. Maui (Hawaii); 1994.
36. Vining D.J. Virtual colonoscopy: the inside story. In: Dachman A. (Ed). Atlas of virtual colonoscopy (2003), Springer-Verlag, New York 3-4
37. Lefkovitz Z., Shapiro R., Koch S., et al. The emerging role of virtual colonoscopy. Med Clin North Am 89 (2005) 111-138
38. Chan C.C., Loke T.K., Chan J.C., et al. Comparison of two oral evacuants (Citromag and Golytely) for bowel preparation before barium enema. Br J Radiol 70 (1997) 1000-1003
39. Macari M., Lavelle M., Pedrosa I., et al. Effect of different bowel preparations on residual fluid at CT colonography. Radiology 218 (2001) 274-277
40. Macari M., and Bini E.J. CT colonography: where have we been and where are we going?. Radiology 237 (2005) 819-833
41. Fletcher J.G., Johnson C.D., Welch T.J., et al. Optimization of CT colonography technique: prospective trial in 180 patients. Radiology 216 (2000) 704-711
42. Pineau B.C., Paskett E.D., Chen G.J., et al. Virtual colonoscopy using oral contrast compared with colonoscopy for the detection of patients with colorectal polyps. Gastroenterology 125 (2003) 304-310
43. Lefere P.A., Gryspeerdt S.S., Dewyspelaere J., et al. Dietary fecal tagging as a cleansing method before CT colonography: initial results-polyp detection and patient acceptance. Radiology 224 (2002) 393-403
44. Lefere P., Gryspeerdt S., Marrannes J., et al. CT colonography after fecal tagging with a reduced cathartic cleansing and a reduced volume of barium. AJR Am J Roentgenol 184 (2005) 1836-1842
45. Shinners T.J., Pickhardt P.J., Taylor A.J., et al. Patient-controlled room air insufflation versus automated carbon dioxide delivery for CT colonography. AJR Am J Roentgenol 186 (2006) 1491-1496
46. Burling D., Taylor S.A., Halligan S., et al. Automated insufflation of carbon dioxide for MDCT colonography: distention and patient experience compared with manual insufflation. AJR Am J Roentgenol 186 (2006) 96-103
47. Burling D., Halligan S., Slater A., et al. Potentially serious adverse events at CT colonography in symptomatic patients: national survey of the United Kingdom. Radiology 239 (2006) 464-471
48. Young B.M., Fletcher J.G., Earnest F., et al. Colonic perforation at CT colonography in a patient without known colonic disease. AJR Am J Roentgenol 186 (2006) 119-121
49. Sosna J., Blachar A., Barmeir E., et al. Colonic perforation at CT colonography: assessment of risk in a multicenter cohort. Radiology 239 (2006) 457-463
50. Harned R.K., Stelling C.B., Williams S., et al. Glucagon and barium enema examinations: a controlled clinical trial. AJR Am J Roentgenol 126 (1976) 981-984
51. Bova J.G., Jurdi R.A., and Bennett W.F. Antispasmodic drugs to reduce discomfort and colonic spasm during barium enemas: comparison of oral hyoscyamine, IV glucagon, and no drug. AJR Am J Roentgenol 161 (1993) 965-968
52. Meeroff J.C., Jorgens J., and Isenberg J.I. The effect of glucagon on barium enema examinations. Radiology 115 (1975) 5-7
53. Yee J., Hung R.K., Akerkar G.A., et al. The usefulness of glucagon hydrochloride for colonic distension in CT colonography. AJR Am J Roentgenol 173 (1999) 169-172
54. Barish M.A., and Rocha T.C. Multislice CT colonography: current status and limitations. Radiol Clin North Am 43 (2005) 1049-1062
55. Mulhall B.P., Veerappan G.R., and Jackson J.F. Meta-analysis: computed tomographic colonography. Ann Intern Med 142 (2005) 635-650
56. Barish M.A., Soto J.A., and Ferrucci J.T. Consensus on current clinical practice of CT colonography. AJR Am J Roentgenol 184 (2005) 786-792
57. Morrin M.M., Farrell R.J., Kruskal J.B., et al. Utility of intravenously administered contrast material at CT colonography. Radiology 217 (2000) 765-771
58. Sosna J., Morrin M.M., Kruskal J.B., et al. Colorectal neoplasms: role of intravenous contrast-enhanced CT colonography. Radiology 228 (2003) 152-156
59. Filippone A., Ambrosini R., Fuschi M., et al. Preoperative T and N staging of colorectal cancer: accuracy of contrast-enhanced multi-detector row CT colonography-initial experience. Radiology 231 (2004) 83-90
60. Fletcher J.G., Johnson C.D., Krueger W.R., et al. Contrast-enhanced CT colonography in recurrent colorectal carcinoma: feasibility of simultaneous evaluation for metastatic disease, local recurrence, and metachronous neoplasia in colorectal carcinoma. AJR Am J Roentgenol 178 (2002) 283-290
61. Yee J. Screening CT colonography. Radiol Clin North Am 42 (2004) 757-766
62. Macari M., Milano A., Lavelle M., et al. Comparison of time-efficient CT colonography with two- and three-dimensional colonic evaluation for detecting colorectal polyps. AJR Am J Roentgenol 174 (2000) 1543-1549
63. Pickhardt P.J., Choi J.R., Hwang I., et al. CT colonography to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 349 (2003) 2191-2200
64. Laks S., Macari M., and Bini E. Positional change in colon polyps at CT colonography. Radiology 231 (2004) 761-766
65. Pickhardt P.J. Differential diagnosis of polypoid lesions seen at CT colonography (virtual colonoscopy). Radiographics 24 (2004) 1535-1559
66. Mang T., Maier A., Plank C., et al. Pitfalls in multi-detector row CT colonography: a systematic approach. Radiographics 27 (2007) 431-454
67. Macari M., and Megibow A.J. Pitfalls of using three-dimensional CT colonography with two-dimensional imaging correlation. AJR Am J Roentgenol 176 (2001) 137-143
68. Park S.H., Lee S.S., Choi E.K., et al. Flat colorectal neoplasms: definition, importance, and visualization on CT colonography. AJR Am J Roentgenol 188 (2007) 953-959
69. Yee J., Akerkar G.A., Hung R.K., et al. Colorectal neoplasia: performance characteristics of CT colonography for detection in 300 patients. Radiology 219 (2001) 685-692
70. Cotton P.B., Durkalski V.L., Pineau B.C., et al. Computed tomographic colonography (CT colonography): a multicenter comparison with standard colonoscopy for detection of colorectal neoplasia. JAMA 291 (2004) 1713-1718
71. Edwards J.T., Mendelson R.M., Fritschi L., et al. Colorectal neoplasia screening with CT colonography in average-risk asymptomatic subjects: community-based study. Radiology 230 (2004) 459-464
72. Johnson C.D., Harmsen W.S., Wilson L.A., et al. Prospective blinded evaluation of computed tomographic colonography for screen detection of colorectal polyps. Gastroenterology 125 (2003) 311-319
73. Iannaccone R., Laghi A., Catalano C.R., et al. Computed tomographic colonography without cathartic preparation for the detection of colorectal polyps. Gastroenterology 127 (2004) 1300-1311
74. Macari M., Bini E.J., Jacobs S.L., et al. Colorectal polyps and cancers in asymptomatic average-risk patients: evaluation with CT colonography. Radiology 230 (2004) 629-636
75. Rockey D.C., Paulson E., Niedzwiecki D., et al. Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison. Lancet 365 (2005) 305-311
76. Rembacken B.J., Fujii T., Cairns A., et al. Flat and depressed colonic neoplasms: a prospective study of 1000 colonoscopies in the UK. Lancet 355 (2000) 1211-1214
77. Pickhardt P.J., Nugent P.A., and Choi J.R. Flat colorectal lesions in asymptomatic adults: implications for screening with CT colonography. AJR Am J Roentgenol 183 (2004) 1343-1347
78. Jaramillo E., Watanabe M., Slezak P., et al. Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc 42 (1995) 114-122
79. Saitoh Y., Wasman I., West A.B., et al. Prevalence and distinctive biologic features of flat colorectal adenomas in a North American population. Gastroenterology 120 (2001) 1657-1665
80. O'Brien M.J., Winawer S.J., Zauber A.G., et al. Flat adenomas in the National Polyp Study: is there increased risk for high-grade dysplasia initially or during surveillance?. Clin Gastroenterol Hepatol 2 (2004) 905-911
81. Andersen K., Vogt C., Blondin D., et al. Multi-detector CT-colonography in inflammatory bowel disease: prospective analysis of CT-findings to high-resolution video colonoscopy. Eur J Radiol 58 (2006) 140-146
82. Ota Y., Matsui T., Ono H., et al. Value of virtual computed tomographic colonography for Crohn's colitis: comparison with endoscopy and barium enema. Abdom Imaging 28 (2003) 778-783
83. Serracino-Inglott F., Atkinson H.D.E., Jha P., et al. Early experiences with computed axial tomography colonography. Am J Surg 187 (2004) 511-514
84. Hara A.K. Extracolonic findings at CT colonography. Semin Ultrasound CT MR 26 (2005) 24-27
85. Xiong T., Richardson M., Woodroffe R., et al. Incidental lesions found on CT colonography: their nature and frequency. Br J Radiol 78 (2005) 22-29
86. Chin M., Mendelson R., Edwards J., et al. Computed tomographic colonography. Am J Gastroenterol 100 (2005) 2771-2776
87. Ginnerup Pedersen B., Rosenkilde M., Christiansen T.E., et al. Extracolonic findings at computed tomography colonography are a challenge. Gut 52 (2003) 1744-1747
88. Gluecker T.M., Johnson C.D., Wilson L.A., et al. Extracolonic findings at CT colonography: evaluation of prevalence and cost in a screening population. Gastroenterology 124 (2003) 911-916
89. Hellstrom M., Svensson M.H., and Lasson A. Extracolonic and incidental findings on CT colonography (virtual colonoscopy). AJR Am J Roentgenol 182 (2004) 631-638
90. Khan K.Y., Xiong T., McCafferty I., et al. Frequency and impact of extracolonic findings detected at computed tomographic colonography in a symptomatic population. Br J Surg 94 (2007) 355-361
91. Pilch-Kowalczyk J., Konopka M., Gibinska J., et al. Extracolonic findings at CT colonography: additional advantage of the method. Med Sci Monit 10 Suppl 3 (2004) 22-25
92. Rajapaksa R.C., Macari M., and Bini E.J. Prevalence and impact of extracolonic findings in patients undergoing CT colonography. J Clin Gastroenterol 38 (2004) 767-771
93. Spreng A., Netzer P., Mattich J., et al. Importance of extracolonic findings at IV contrast medium-enhanced CT colonography versus those at non-enhanced CT colonography. Eur Radiol 15 (2005) 2088-2095
94. Yee J., Kumar N.N., Godara S., et al. Extracolonic abnormalities discovered incidentally at CT colonography in a male population. Radiology 236 (2005) 519-526
95. Pickhardt P.J., and Taylor A.J. Extracolonic findings identified in asymptomatic adults at screening CT colonography. AJR Am J Roentgenol 186 (2006) 718-728
96. Sosna J., Krukal J.B., Bar-Ziv J., et al. Extracolonic findings at CT colonography. Abdom Imaging 30 (2005) 709-713
97. Hara A.K., Johnson C.D., MacCarty R.L., et al. Incidental extracolonic findings at CT colonography. Radiology 215 (2000) 353-357
98. European Society of Gastrointestinal and Abdominal Radiology CT Colonography Study Group Investigators. Effect of directed training on reader performance for CT colonography: multicenter study. Radiology 242 (2007) 152-161
99. Soto J.A., Barish M.A., and Yee J. Reader training in CT colonography: how much is enough?. Radiology 237 (2005) 26-27
100. Shah H.A., Paszat L.F., Saskin R., et al. Factors associated with incomplete colonoscopy: a population-based study. Gastroenterology 132 (2007) 2297-2303
101. Fenlon H.M., McAneny D.B., and Nunes D.P. Occlusive colon carcinoma: CT colonography in the preoperative evaluation of the proximal colon. Radiology 210 (1999) 423-428
102. Rex D.K. Is virtual colonoscopy ready for widespread application?. Gastroenterology 125 (2003) 608-614
103. Rex D.K., and Lieberman D. ACG colorectal cancer prevention action plan: update on CT-colonography. Am J Gastroenterol 101 (2006) 1410-1413
104. Pickhardt P.J. Response letter. Ann Intern Med 142 (2005) 155
105. Cappell M.S., and Friedel D. The role of sigmoidoscopy and colonoscopy in the diagnosis and management of lower gastrointestinal disorders: endoscopic findings, therapy, and complications. Med Clin North Am 86 (2002) 1253-1288
106. Rex D.K. Pro: patients with polyps smaller than 1 cm on computed tomographic colonography should be offered colonoscopy and polypectomy. Am J Gastroenterol 100 (2005) 1903-1905
107. Butterly L.F., Chase M.P., Pohl H., et al. Prevalence of clinically important histology in small adenomas. Clin Gastroenterol Hepatol 4 (2006) 343-348
108. Kim D.H., Pickhardt P.J., and Taylor A.J. Characteristics of advanced adenomas detected at CT colonographic screening: implications for appropriate polyp size thresholds for polypectomy versus surveillance. AJR Am J Roentgenol 188 (2007) 940-944
109. Ransohoff D.F. Con: immediate colonoscopy is not necessary in patients who have polyps smaller than 1 cm on computed tomographic colonography. Am J Gastroenterol 100 (2005) 1905-1907
110. Rex D.K. American College of Gastroenterology action plan for colorectal cancer prevention. Am J Gastroenterol 99 (2004) 574-577
111. Pickhardt P.J., Hassan C., Laghi A., et al. Cost-effectiveness of colorectal cancer screening with computed tomography colonography: the impact of not reporting diminutive lesions. Cancer 109 (2007) 2213-2221
112. Callstrom M.R., Johnson C.D., Fletcher J.G., et al. CT colonography without cathartic preparation: feasibility study. Radiology 219 (2001) 693-698
113. Zalis M.E., Perumpillichira J., Del Ferate C., et al. CT colonography: digital subtraction bowel cleansing with mucosal reconstruction-initial observations. Radiology 226 (2003) 911-917
114. Summers R.M., Johnson C.D., Pusanik L.M., et al. Automated polyp detection at CT colonography: feasibility study in a human population. Radiology 219 (2001) 51-59
115. Taylor S.A., Halligan S., Burling D., et al. Computer-assisted reader software versus expert reviewers for polyp detection on CT colonography. AJR Am J Roentgenol 186 (2006) 696-702
116. Dachman A.H., Lefere P., Gryspeerdt S., et al. CT colonography: visualization methods, interpretation, and pitfalls. Radiol Clin North Am 45 (2007) 347-359
117. Ajaj W., Pelster G., Treichel U., et al. Dark lumen magnetic resonance colonography: comparison with conventional colonoscopy for detection of colorectal pathology. Gut 52 (2003) 1738-1743
118. MacKalski B.A., and Bernstein C.N. New diagnostic imaging tools for inflammatory bowel disease. Gut 55 (2006) 733-741