Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A

Journal of Neurochemistry

Volumn 66, Issue 2, 1996, Pages 817-823

  Johansen, Patricia A ^a   Jennings, Ian ^b   Cotton, Richard G H ^b   Kuhn, Donald M ^a,c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c Metropol Center for High Technology   (United States)

Author keywords

Activation; Phosphorylation; Protein kinase A; Tryptophan hydroxylase

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

ANIMALIA;

EID: 0030050954     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66020817.x     Document Type: Article

References (33)

1. Beavo J. A., Bechtel P. J., and Krebs E. G. (1974) Preparation of homogenous cyclic AMP dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods Enzymol. 38, 299-308.
2. 2′-dibutyryl adenosine-3′:5′-cyclic monophosphate. Biochem. Pharmacol. 29, 669-672.
3. Boadle-Biber M. C. (1982) Blockade by haloperidol of the increase in tryptophan hydroxylase activity induced by incubation of slices of brain stem with dibutyryl cyclic AMP. Biochem. Pharmacol. 31, 2203-2207.
4. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Campbell D G., Hardie D. G., and Vulliet P. R. (1986) Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. J. Biol. Chem. 261, 10489-10492.
6. Cotton R. G. H., McAdam W., Jennings I., and Morgan F. J. (1988) A monoclonal antibody to aromatic amino acid hydroxylases: identification of the epitope. Biochem. J. 255, 193-196.
7. Darmon M. C., Guibert B., Leviel V., Ehret M., Maitre M., and Mallet J. (1988) Sequence of two mRNAs encoding active rat tryptophan hydroxylase. J. Neurochem. 51, 312-316.
8. 2+/calmodulin dependent protein kinase. J. Neurochem 52, 1886-1891.
9. Francis S. H. and Corbin J. D. (1994) Structure and function of cyclic nucleotide-dependent protein kinases. Annu. Rev. Physiol. 56, 237-272.
10. Garber S. L. and Makman M. H. (1987) Regulation of tryptophan hydroxylase activity by a cyclic AMP-dependent mechanism in rat striatum. Mol. Brain Res. 3, 1-10.
11. Grennet H. E., Ledley F. D., Reed L. L., and Woo S. L. C. (1987) Functional domains and evolution of aromatic amino acid hydroxylases. Proc. Natl. Acad. Sci. U.S.A. 84, 5530-5534.
12. Hamon M., Bourgoin S., Hery F., and Simonnet G. (1978) Activation of tryptophan hydroxylase by adenosine triphosphate, magnesium, and calcium. Mol. Pharmacol. 14, 99-110.
13. Ichiyama A., Hasegawa H., Tohyama C., Dohmoto C., and Kataoka T (1976) Some properties of bovine pineal tryptophan hydroxylase. Adv. Exp Med. Biol. 74, 103-117.
14. Jequier E., Lovenberg W., and Sjoerdsma A. (1967) Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Mol. Pharmacol. 3, 274-278.
15. Joh T H., Park D. H., and Reis D. J. (1978) Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. Proc. Natl. Acad. Sci. U.S.A. 75, 4744-4748.
16. Johansen P. A., Wolf W. A., and Kuhn D. M. (1991) Inhibition of tryptophan hydroxylase by benserazide and other catechols. Biochem. Pharmacol. 41, 625-628.
17. Johansen P. A., Jennings I., Cotton R. G. H., and Kuhn D. M. (1992) Immobilization of tryptophan hydroxylase by immune adsorption: a method to study regulation of catalytic activity. Brain Res. Bull. 29, 949-953.
18. Johansen P. A., Jennings I., Cotton R. G. H., and Kuhn D. M. (1995) Tryptophan hydroxylase is phosphorylated by protein kinase A. J. Neurochem. 65, 882-888.
19. Kuhn D. M., Vogel R. L., and Lovenberg W. (1978) Calcium-dependent activation of tryptophan hydroxylase by ATP and magnesium Biochem. Biophys. Res. Commun. 82, 759-766.
20. 2+: dependence on calmodulin. Proc. Natl. Acad. Sci U.S.A. 77, 4688-4691.
21. Kuhn D. M., Ruskin B., and Lovenberg W. (1980b) Tryptophan hydroxylase: the role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity. J. Biol. Chem. 255, 4137-4143.
22. Makita Y., Okuno S., and Fujisawa H. (1990) Involvement of activator protein in the activation of tryptophan hydroxylase by cyclic AMP-dependent protein kinase. FEBS Lett. 268, 185-188.
23. O'Farrell P. H. (1975) High resolution two dimensional electrophoresis of proteins. J. Biol. Chem. 250, 4007-4021.
24. Roskoski R. and Roskoski L. M. (1987) Activation of tyrosine hydroxylase in PC12 cells by the cyclic GMP and cyclic AMP second messenger systems. J. Neurochem. 48, 236-242
25. Sawada M. and Nagatsu T. (1986) Stimulation of the serotonin autoreceptor prevents the calcium-calmodulin-dependent increase of serotonin biosynthesis in rat raphe slices. J. Neurochem. 46, 963-967.
26. Sawada M., Kanamori T., Hayakawa T., and Nagatsu T. (1985) Changes in activities of tryptophan hydroxylase and cyclic AMP-dependent and calcium-calmodulin-dependent protein kinases in raphe serotonergic neurons of 5,7-dihydroxytryptamine-treated rats. Neurochem. Int. 7, 761-763.
27. Tagliamonte A., Tagliamonte P., Forn J., Perez-Cruet J., Krishna G., and Gessa G. L. (1971) Stimulation of brain serotonin synthesis by dibutyryl-cyclic AMP in rats. J. Neurochem. 18, 1191-1196.
28. Vrana K. E., Rucker P. J., and Kumer S. C. (1994) Recombinant rabbit tryptophan hydroxylase is a substrate from cAMP-dependent protein kinase. Life Sci. 55, 1045-1052.
29. Vulliet P. R., Langan T. A., and Weiner N. (1980) Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 77, 92-96.
30. Yamauchi T. and Fujisawa H. (1979a) In vitro phosphorylation of bovine adrenal tyrosine hydroxylase by adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem. 254, 503-507.
31. Yamauchi T. and Fujisawa H. (1979b) Regulation of bovine adrenal tyrosine 3-monooxygenase by phosphorylation-dephosphorylation reaction, catalyzed by adenosine 3′:5′-monophosphate-dependent protein kinase and phosphoprotein phosphatase. J. Biol. Chem. 254, 6408-6413.
32. Yamauchi T. and Fujisawa H. (1979c) Regulation of rat brainstem tryptophan 5-monooxygenase- Calcium-dependent reversible activation by ATP and magnesium. Arch. Biochem. Biophys. 198, 219-226.
33. Zigmond R. E., Schwarzschild M. A., and Rittenhouse A. R. (1989) Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu. Rev. Neurosci. 12, 415-461.