Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line

European Journal of Biochemistry

Volumn 269, Issue 19, 2002, Pages 4780-4788

  Iida, Yoshiko ^a   Sawabe, Keiko ^a   Kojima, Masayo ^a   Oguro, Kazuya ^a   Nakanishi, Nobuo ^b   Hasegawa, Hiroyuki ^a  

^a TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

CaM kinase II; Enzyme turnover; Proteasome target; Tetrahydrobiopterin; Ubiquitin ligase

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ALOXISTATIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALCIUM ION; CALMODULIN; CELL EXTRACT; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOHEXIMIDE; K 252A; LACTACYSTIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PHOSPHORUS 32; PROTEASOME; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE INHIBITOR; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; ENZYME SPECIFICITY; MAST CELL; MASTOCYTOMA; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CELL-FREE SYSTEM; ENZYME INHIBITORS; KINETICS; MAST CELLS; PEPTIDE HYDROLASES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; RATS; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ANIMALIA; IKEDA;

EID: 0036399655     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03188.x     Document Type: Article

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