메뉴 건너뛰기




Volumn 49, Issue 3, 2008, Pages 427-438

Iron overload in myelodysplastic syndromes

Author keywords

Myeloid leukemias and dysplasias; Pharmacotherapeutics; Prognostication

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN; HEMOGLOBIN; HEPCIDIN; IRON; IRON CHELATING AGENT; PLACEBO; TRANSFERRIN;

EID: 39749126765     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190701843221     Document Type: Review
Times cited : (34)

References (62)
  • 1
    • 0033609317 scopus 로고    scopus 로고
    • Myelodysplasia
    • Heaney, M. L. and Golde, D. W. (1999) Myelodysplasia. N Engl J Med, 340, pp. 1649-1660.
    • (1999) N Engl J Med , vol.340 , pp. 1649-1660
    • Heaney, M.L.1    Golde, D.W.2
  • 2
    • 30144443817 scopus 로고    scopus 로고
    • The myelodysplastic syndromes: Diagnosis and treatment
    • Steensma, D. P. and Bennett, J. M. (2006) The myelodysplastic syndromes: diagnosis and treatment. Mayo Clin Proc, 81, pp. 104-130.
    • (2006) Mayo Clin Proc , vol.81 , pp. 104-130
    • Steensma, D.P.1    Bennett, J.M.2
  • 3
    • 0034986843 scopus 로고    scopus 로고
    • Survival analysis and AML development in patients with de novo myelodysplastic syndromes: Comparison of six different prognostic scoring systems
    • Sperr, W. R., Wimazal, F., Kundi, M., Fonatsch, C., Thalhammer-Scherrer, R. and Schernthaner, G. H. (2001) Survival analysis and AML development in patients with de novo myelodysplastic syndromes: Comparison of six different prognostic scoring systems. Ann Hematol, 80, pp. 272-277.
    • (2001) Ann Hematol , vol.80 , pp. 272-277
    • Sperr, W.R.1    Wimazal, F.2    Kundi, M.3    Fonatsch, C.4    Thalhammer-Scherrer, R.5    Schernthaner, G.H.6
  • 4
    • 0023089077 scopus 로고
    • Utility of the FAB classification for myelodysplastic syndromes: Investigation of prognostic factors in 237 cases
    • Kerkhofs, H., Hermans, J., Haak, H. L. and Leeksma, C. H. (1987) Utility of the FAB classification for myelodysplastic syndromes: Investigation of prognostic factors in 237 cases. Br J Haematol, 65, pp. 73-81.
    • (1987) Br J Haematol , vol.65 , pp. 73-81
    • Kerkhofs, H.1    Hermans, J.2    Haak, H.L.3    Leeksma, C.H.4
  • 5
    • 0035892129 scopus 로고    scopus 로고
    • Myelodysplastic syndromes, from French - American - British to World Health Organization: Comparison of classifications on 431 unselected patients from a single institution
    • Nosslinger, T., Reisner, R., Koller, E., Gruner, H., Tuchler, H. and Nowotny, H. (2001) Myelodysplastic syndromes, from French - American - British to World Health Organization: Comparison of classifications on 431 unselected patients from a single institution. Blood, 98, pp. 2935-2941.
    • (2001) Blood , vol.98 , pp. 2935-2941
    • Nosslinger, T.1    Reisner, R.2    Koller, E.3    Gruner, H.4    Tuchler, H.5    Nowotny, H.6
  • 6
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg, P., Cox, C., LeBeau, M. M., Fenaux, P., Morel, P. and Sanz, G. (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89, pp. 2079-2088.
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    LeBeau, M.M.3    Fenaux, P.4    Morel, P.5    Sanz, G.6
  • 7
    • 0032784783 scopus 로고    scopus 로고
    • World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997
    • Harris, N. L., Jaffe, E. S., Diebold, J., Flandrin, G., Muller-Hermelink, H. K. and Vardiman, J. (1999) World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol, 17, pp. 3835-3849.
    • (1999) J Clin Oncol , vol.17 , pp. 3835-3849
    • Harris, N.L.1    Jaffe, E.S.2    Diebold, J.3    Flandrin, G.4    Muller-Hermelink, H.K.5    Vardiman, J.6
  • 8
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List, A., Dewald, G., Bennett, J., Giagounidis, A., Raza, A. and Feldman, E. (2006) Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med, 355, pp. 1456-1465.
    • (2006) N Engl J Med , vol.355 , pp. 1456-1465
    • List, A.1    Dewald, G.2    Bennett, J.3    Giagounidis, A.4    Raza, A.5    Feldman, E.6
  • 9
    • 32144431895 scopus 로고    scopus 로고
    • Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: A basis for clinical decision making
    • Malcovati, L., Porta, M. G., Pascutto, C., Invernizzi, R., Boni, M. and Travaglino, E. (2005) Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: A basis for clinical decision making. J Clin Oncol, 23, pp. 7594-7603.
    • (2005) J Clin Oncol , vol.23 , pp. 7594-7603
    • Malcovati, L.1    Porta, M.G.2    Pascutto, C.3    Invernizzi, R.4    Boni, M.5    Travaglino, E.6
  • 10
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park, C. H., Valore, E. V., Waring, A. J. and Ganz, T. (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem, 276, pp. 7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 11
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B. and Kahn, A. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA, 98, pp. 8780-8785.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6
  • 13
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I. and Robine, S. (2005) The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab, 1, pp. 191-200.
    • (2005) Cell Metab , vol.1 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3    Pinkus, G.S.4    Zon, L.I.5    Robine, S.6
  • 14
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A. and Ward, D. M. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, pp. 2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 15
    • 13444252281 scopus 로고    scopus 로고
    • Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
    • Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, F. and Wessling-Resnick, M. (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci USA, 102, pp. 1324-1328.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1324-1328
    • Knutson, M.D.1    Oukka, M.2    Koss, L.M.3    Aydemir, F.4    Wessling-Resnick, M.5
  • 16
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • Nemeth, E. and Ganz, T. (2006) Regulation of iron metabolism by hepcidin. Annu Rev Nutr, 26, pp. 323-342.
    • (2006) Annu Rev Nutr , vol.26 , pp. 323-342
    • Nemeth, E.1    Ganz, T.2
  • 19
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity
    • Hershko, C., Graham, G., Bates, G. W. and Rachmilewitz, E. A. (1978) Non-specific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity. Br J Haematol, 40, pp. 255-263.
    • (1978) Br J Haematol , vol.40 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.W.3    Rachmilewitz, E.A.4
  • 21
    • 0033677772 scopus 로고    scopus 로고
    • The importance of non-transferrin bound iron in disorders of iron metabolism
    • Breuer, W., Hershko, C. and Cabantchik, Z. I. (2000) The importance of non-transferrin bound iron in disorders of iron metabolism. Transfus Sci, 23, pp. 185-192.
    • (2000) Transfus Sci , vol.23 , pp. 185-192
    • Breuer, W.1    Hershko, C.2    Cabantchik, Z.I.3
  • 22
    • 0141705304 scopus 로고    scopus 로고
    • Labile plasma iron in iron overload: Redox activity and susceptibility to chelation
    • Esposito, B. P., Breuer, W., Sirankapracha, P., Pootrakul, P., Hershko, C. and Cabantchik, Z. I. (2003) Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood, 102, pp. 2670-2677.
    • (2003) Blood , vol.102 , pp. 2670-2677
    • Esposito, B.P.1    Breuer, W.2    Sirankapracha, P.3    Pootrakul, P.4    Hershko, C.5    Cabantchik, Z.I.6
  • 23
    • 4444274916 scopus 로고    scopus 로고
    • Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator
    • Pootrakul, P., Breuer, W., Sametband, M., Sirankapracha, P., Hershko, C. and Cabantchik, Z. I. (2004) Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator. Blood, 104, pp. 1504-1510.
    • (2004) Blood , vol.104 , pp. 1504-1510
    • Pootrakul, P.1    Breuer, W.2    Sametband, M.3    Sirankapracha, P.4    Hershko, C.5    Cabantchik, Z.I.6
  • 24
    • 0022021390 scopus 로고
    • Auto-oxidation and a membrane-associated 'Fenton reagent': A possible explanation for development of membrane lesions in sickle erythrocytes
    • Hebbel, R. P. (1985) Auto-oxidation and a membrane-associated 'Fenton reagent': A possible explanation for development of membrane lesions in sickle erythrocytes. Clin Haematol, 14, pp. 129-140.
    • (1985) Clin Haematol , vol.14 , pp. 129-140
    • Hebbel, R.P.1
  • 25
    • 21144441802 scopus 로고    scopus 로고
    • Redox active plasma iron in C282Y/C282Y hemochromatosis
    • Lan, C Le, Loreal, O., Cohen, T., Ropert, M., Glickstein, H. and Laine, F. (2005) Redox active plasma iron in C282Y/C282Y hemochromatosis. Blood, 105, pp. 4527-4531.
    • (2005) Blood , vol.105 , pp. 4527-4531
    • Lan Le, C.1    Loreal, O.2    Cohen, T.3    Ropert, M.4    Glickstein, H.5    Laine, F.6
  • 26
    • 0023350965 scopus 로고
    • Non-transferrin plasma iron
    • Hershko, C. and Peto, T. E. (1987) Non-transferrin plasma iron. Br J Haematol, 66, pp. 149-151.
    • (1987) Br J Haematol , vol.66 , pp. 149-151
    • Hershko, C.1    Peto, T.E.2
  • 27
    • 0022111669 scopus 로고
    • Heart cells in culture: A model of myocardial iron overload and chelation
    • Link, G., Pinson, A. and Hershko, C. (1985) Heart cells in culture: A model of myocardial iron overload and chelation. J Lab Clin Med, 106, pp. 147-153.
    • (1985) J Lab Clin Med , vol.106 , pp. 147-153
    • Link, G.1    Pinson, A.2    Hershko, C.3
  • 28
    • 0034585292 scopus 로고    scopus 로고
    • Non-transferrin-bound iron in myelodysplastic syndromes: A marker of ineffective erythropoiesis?
    • Cortelezzi, A., Cattaneo, C., Cristiani, S., Duca, L., Sarina, B. and Deliliers, G. L. (2000) Non-transferrin-bound iron in myelodysplastic syndromes: A marker of ineffective erythropoiesis?. Hematol J, 1, pp. 153-158.
    • (2000) Hematol J , vol.1 , pp. 153-158
    • Cortelezzi, A.1    Cattaneo, C.2    Cristiani, S.3    Duca, L.4    Sarina, B.5    Deliliers, G.L.6
  • 29
    • 0031001278 scopus 로고    scopus 로고
    • Iron-chelating therapy and the treatment of thalassemia
    • Olivieri, N. F. and Brittenham, G. M. (1997) Iron-chelating therapy and the treatment of thalassemia. Blood, 89, pp. 739-761.
    • (1997) Blood , vol.89 , pp. 739-761
    • Olivieri, N.F.1    Brittenham, G.M.2
  • 31
    • 0028059813 scopus 로고
    • Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major
    • Brittenham, G. M., Griffith, P. M., Nienhuis, A. W., McLaren, C. E., Young, N. S. and Tucker, E. E. (1994) Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med, 331, pp. 567-573.
    • (1994) N Engl J Med , vol.331 , pp. 567-573
    • Brittenham, G.M.1    Griffith, P.M.2    Nienhuis, A.W.3    McLaren, C.E.4    Young, N.S.5    Tucker, E.E.6
  • 32
    • 0021833690 scopus 로고
    • Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major
    • Wolfe, L., Olivieri, N., Sallan, D., Colan, S., Rose, V. and Propper, R. (1985) Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med, 312, pp. 1600-1603.
    • (1985) N Engl J Med , vol.312 , pp. 1600-1603
    • Wolfe, L.1    Olivieri, N.2    Sallan, D.3    Colan, S.4    Rose, V.5    Propper, R.6
  • 33
    • 0344645697 scopus 로고
    • The liver in thalassemia major: Ultra-structural observations
    • Iancu, T C NH and Landing, B. H. (1977) The liver in thalassemia major: ultra-structural observations. Iron Metab Ciba Foundation Symp, 51, pp. 293-307.
    • (1977) Iron Metab Ciba Foundation Symp , vol.51 , pp. 293-307
    • Iancu, T.C.N.H.1    Landing, B.H.2
  • 34
  • 35
    • 12544259078 scopus 로고    scopus 로고
    • Diabetes mellitus and impaired glucose tolerance in thalassaemia major: Incidence, prevalence, risk factors and survival in patients followed in the Ferrara Center
    • Gamberini, M. R., Fortini, M., De Sanctis, V., Gilli, G. and Testa, M. R. (2004) Diabetes mellitus and impaired glucose tolerance in thalassaemia major: Incidence, prevalence, risk factors and survival in patients followed in the Ferrara Center. Pediatr Endocrinol Rev, 2, pp. 285-291.
    • (2004) Pediatr Endocrinol Rev , vol.2 , pp. 285-291
    • Gamberini, M.R.1    Fortini, M.2    De Sanctis, V.3    Gilli, G.4    Testa, M.R.5
  • 36
    • 0022368621 scopus 로고
    • Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis
    • Niederau, C., Fischer, R., Sonnenberg, A., Stremmel, W., Trampisch, H. J. and Strohmeyer, G. (1985) Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med, 313, pp. 1256-1262.
    • (1985) N Engl J Med , vol.313 , pp. 1256-1262
    • Niederau, C.1    Fischer, R.2    Sonnenberg, A.3    Stremmel, W.4    Trampisch, H.J.5    Strohmeyer, G.6
  • 39
    • 0035132419 scopus 로고    scopus 로고
    • Non-invasive methods for quantitative assessment of transfusional iron overload in sickle cell disease
    • Brittenham, G. M., Sheth, S., Allen, C. J. and Farrell, D. E. (2001) Non-invasive methods for quantitative assessment of transfusional iron overload in sickle cell disease. Semin Hematol, 38, pp. 37-56.
    • (2001) Semin Hematol , vol.38 , pp. 37-56
    • Brittenham, G.M.1    Sheth, S.2    Allen, C.J.3    Farrell, D.E.4
  • 40
    • 0037930751 scopus 로고    scopus 로고
    • Monitoring long-term efficacy of iron chelation therapy by deferiprone and desferrioxamine in patients with beta-thalassaemia major: Application of SQUID biomagnetic liver susceptometry
    • Fischer, R., Longo, F., Nielsen, P., Engelhardt, R., Hider, R. C. and Piga, A. (2003) Monitoring long-term efficacy of iron chelation therapy by deferiprone and desferrioxamine in patients with beta-thalassaemia major: Application of SQUID biomagnetic liver susceptometry. Br J Haematol, 121, pp. 938-948.
    • (2003) Br J Haematol , vol.121 , pp. 938-948
    • Fischer, R.1    Longo, F.2    Nielsen, P.3    Engelhardt, R.4    Hider, R.C.5    Piga, A.6
  • 41
    • 11244355277 scopus 로고    scopus 로고
    • Non-invasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    • St. Pierre, T. G., Clark, P. R., Chua-anusorn, W., Fleming, A. J., Jeffrey, G. P. and Olynyk, J. K. (2005) Non-invasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood, 105, pp. 855-861.
    • (2005) Blood , vol.105 , pp. 855-861
    • St. Pierre, T.G.1    Clark, P.R.2    Chua-anusorn, W.3    Fleming, A.J.4    Jeffrey, G.P.5    Olynyk, J.K.6
  • 42
    • 18044399191 scopus 로고    scopus 로고
    • Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
    • Anderson, L. J., Holden, S., Davis, B., Prescott, E., Charrier, C. C. and Bunce, N. H. (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J, 22, pp. 2171-2179.
    • (2001) Eur Heart J , vol.22 , pp. 2171-2179
    • Anderson, L.J.1    Holden, S.2    Davis, B.3    Prescott, E.4    Charrier, C.C.5    Bunce, N.H.6
  • 43
    • 0021804667 scopus 로고
    • Effects of iron and desferrioxamine on infections with Yersinia enterocolitica
    • Robins-Browne, R. M. and Prpic, J. K. (1985) Effects of iron and desferrioxamine on infections with Yersinia enterocolitica. Infect Immun, 47, pp. 774-779.
    • (1985) Infect Immun , vol.47 , pp. 774-779
    • Robins-Browne, R.M.1    Prpic, J.K.2
  • 45
    • 0025066690 scopus 로고
    • Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients
    • Olivieri, N. F., Koren, G., Hermann, C., Bentur, Y., Chung, D. and Klein, J. (1990) Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients. Lancet, 336, pp. 1275-1279.
    • (1990) Lancet , vol.336 , pp. 1275-1279
    • Olivieri, N.F.1    Koren, G.2    Hermann, C.3    Bentur, Y.4    Chung, D.5    Klein, J.6
  • 46
    • 0042943205 scopus 로고    scopus 로고
    • Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone
    • Cohen, A. R., Galanello, R., Piga, A., De Sanctis, V. and Tricta, F. (2003) Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone. Blood, 102, pp. 1583-1587.
    • (2003) Blood , vol.102 , pp. 1583-1587
    • Cohen, A.R.1    Galanello, R.2    Piga, A.3    De Sanctis, V.4    Tricta, F.5
  • 47
    • 33646677440 scopus 로고    scopus 로고
    • Combined therapy with desferrioxamine and deferiprone in beta thalassemia major patients with transfusional iron overload
    • Daar, S. and Pathare, A. V. (2006) Combined therapy with desferrioxamine and deferiprone in beta thalassemia major patients with transfusional iron overload. Ann Hematol, 85, pp. 315-319.
    • (2006) Ann Hematol , vol.85 , pp. 315-319
    • Daar, S.1    Pathare, A.V.2
  • 48
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • Tanner, M. A., Galanello, R., Dessi, C., Smith, G. C., Westwood, M. A. and Agus, A. (2007) A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation, 115, pp. 1876-1884.
    • (2007) Circulation , vol.115 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3    Smith, G.C.4    Westwood, M.A.5    Agus, A.6
  • 49
    • 33646387405 scopus 로고    scopus 로고
    • Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
    • Pennell, D. J., Berdoukas, V., Karagiorga, M., Ladis, V., Piga, A. and Aessopos, A. (2006) Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood, 107, pp. 3738-3744.
    • (2006) Blood , vol.107 , pp. 3738-3744
    • Pennell, D.J.1    Berdoukas, V.2    Karagiorga, M.3    Ladis, V.4    Piga, A.5    Aessopos, A.6
  • 50
    • 33646407268 scopus 로고    scopus 로고
    • Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
    • Borgna-Pignatti, C., Cappellini, M. D., De Stefano, P., Vecchio, G C Del, Forni, G. L. and Gamberini, M. R. (2006) Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood, 107, pp. 3733-3737.
    • (2006) Blood , vol.107 , pp. 3733-3737
    • Borgna-Pignatti, C.1    Cappellini, M.D.2    De Stefano, P.3    Vecchio, G.C.4    Del Forni, G.L.5    Gamberini, M.R.6
  • 52
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
    • Cappellini, M. D., Cohen, A., Piga, A., Bejaoui, M., Perrotta, S. and Agaoglu, L. (2006) A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood, 107, pp. 3455-3462.
    • (2006) Blood , vol.107 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3    Bejaoui, M.4    Perrotta, S.5    Agaoglu, L.6
  • 53
    • 34248383686 scopus 로고    scopus 로고
    • Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation
    • Armand, P., Kim, H. T., Cutler, C. S., Ho, V. T., Koreth, J. and Alyea, E. P. (2007) Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation. Blood, 109, pp. 4586-4588.
    • (2007) Blood , vol.109 , pp. 4586-4588
    • Armand, P.1    Kim, H.T.2    Cutler, C.S.3    Ho, V.T.4    Koreth, J.5    Alyea, E.P.6
  • 54
    • 39749096149 scopus 로고    scopus 로고
    • Retrospective survey of Japanese patients with transfusion-dependent myelodysplastic syndromes and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality
    • Takatoku, T. U., Okamoto, S., Kanakura, Y., Sawada, K., Tomonaga, M. and Nakao, S. (2006) Retrospective survey of Japanese patients with transfusion-dependent myelodysplastic syndromes and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Blood, p. 108.
    • (2006) Blood , pp. 108
    • Takatoku, T.U.1    Okamoto, S.2    Kanakura, Y.3    Sawada, K.4    Tomonaga, M.5    Nakao, S.6
  • 56
    • 34248584839 scopus 로고    scopus 로고
    • Improved survival in patients with myelodysplastic syndrome (MDS) receiving iron chelation therapy
    • Leitch, H., Goodman, T. A., Wong, K., Vickars, L., Galbraith, P. and Leger, C. (2006) Improved survival in patients with myelodysplastic syndrome (MDS) receiving iron chelation therapy. Blood, p. 108.
    • (2006) Blood
    • Leitch, H.1    Goodman, T.A.2    Wong, K.3    Vickars, L.4    Galbraith, P.5    Leger, C.6
  • 58
    • 39749098012 scopus 로고    scopus 로고
    • Patient characteristics, quality-of-life and compliance with deferoxamine in patients with transfusional iron overload: Results of ISOSFER Study
    • (Intr. by Renaud Capdeville)
    • Thuret, CB-S, Bachir, D., Hacini, M., Pegourie-Bandelier, B., Gardembas-Pain, M. and (Intr. by Renaud Capdeville) (2006) Patient characteristics, quality-of-life and compliance with deferoxamine in patients with transfusional iron overload: Results of ISOSFER Study. Blood, p. 1085513.
    • (2006) Blood , pp. 1085513
    • Thuret, C.B.-S.1    Bachir, D.2    Hacini, M.3    Pegourie-Bandelier, B.4    Gardembas-Pain, M.5
  • 59
    • 77951144863 scopus 로고    scopus 로고
    • Socio-economic impact of infused iron chelation therapy in France: ISOSFER Study results
    • Brun-Strang, C BD, De Montalembert, M. and Thuret, I. (2006) Socio-economic impact of infused iron chelation therapy in France: ISOSFER Study results. Blood, p. 1083354.
    • (2006) Blood , pp. 1083354
    • Brun-Strang, C.B.D.1    De Montalembert, M.2    Thuret, I.3
  • 60
    • 34247271478 scopus 로고    scopus 로고
    • Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective
    • Delea, T. E., Sofrygin, O., Thomas, S. K., Baladi, J. F., Phatak, P. D. and Coates, T. D. (2007) Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective. Pharmacoeconomics, 25, pp. 329-342.
    • (2007) Pharmacoeconomics , vol.25 , pp. 329-342
    • Delea, T.E.1    Sofrygin, O.2    Thomas, S.K.3    Baladi, J.F.4    Phatak, P.D.5    Coates, T.D.6
  • 61
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown, E., Olivieri, N. F., Giardina, P. J., Grady, R. W., Neufeld, E. J. and Sechaud, R. (2003) Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet, 361, pp. 1597-1602.
    • (2003) Lancet , vol.361 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3    Grady, R.W.4    Neufeld, E.J.5    Sechaud, R.6
  • 62
    • 33745774771 scopus 로고    scopus 로고
    • Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
    • Piga, A., Galanello, R., Forni, G. L., Cappellini, M. D., Origa, R. and Zappu, A. (2006) Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica, 91, pp. 873-880.
    • (2006) Haematologica , vol.91 , pp. 873-880
    • Piga, A.1    Galanello, R.2    Forni, G.L.3    Cappellini, M.D.4    Origa, R.5    Zappu, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.