Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: Application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells

Journal of Mass Spectrometry

Volumn 43, Issue 2, 2008, Pages 224-233

  Pruvost, Alain ^a   Théodoro, Frédéric ^a   Agrofoglio, Luigi ^b   Negredo, Eugenia ^c   Bénech, Henri ^a  

^a DIF   (France)

^b UNIVERSITÉ D'ORLÉANS   (France)

^c HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Human PBMC; LC ESI MS MS; NRTI triphosphate; Positive ionization; Specificity

Indexed keywords

BIOASSAY; CELLS; ELECTROSPRAY IONIZATION; ENZYME INHIBITION; MASS SPECTROMETRY; METABOLITES;

NRTI TRIPHOSPHATE; PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC); POSITIVE IONIZATION; SPECIFICITY; TENOFOVIR DIPHOSPHATE;

NUCLEOTIDES;

CARBOVIR; LAMIVUDINE; NUCLEOTIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR;

ACCURACY; ARTICLE; CELL DISRUPTION; DRUG DETERMINATION; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIQUID CHROMATOGRAPHY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SUPERNATANT;

EID: 39749122662     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1294     Document Type: Article

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