BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma

Oncogene

Volumn 27, Issue 9, 2008, Pages 1208-1217

  Chan, B C L ^a   Ching, A K K ^a   To, K F ^b   Leung, J C K ^c   Chen, S ^a   Li, Q ^a,e   Lai, P B S ^b   Tang, N L S ^b   Shaw, P C ^b   Chan, J Y H ^d   James, A E ^b   Lai, K N ^c   Lim, P L ^a   Lee, K K H ^b   Chui, Y L ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF TEXAS   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiapoptosis; BRE; BRE specific monoclonal antibody; Fas mediated acute liver failure; Human hepatocellular carcinoma; Tumorigenesis

Indexed keywords

BRAIN AND REPRODUCTIVE ORGAN-EXPRESSED PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MONOCLONAL ANTIBODY; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MODEL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; HELA CELLS; HUMANS; JURKAT CELLS; LIVER NEOPLASMS; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; NERVE TISSUE PROTEINS;

MUS;

EID: 39749096628     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210733     Document Type: Article

References (39)

1. Aggarwal BB. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3: 745-756.
2. Bai L, Ni HM, Chen X, DiFrancesca D, Yin XM. (2005). Deletion of Bid impedes cell proliferation and hepatic carcinogenesis. Am J Pathol 166: 1523-1532.
3. Barber GN. (2001). Host defense, viruses and apoptosis. Cell Death Differ 8: 113-126.
4. Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL et al. (2005). BRE enhances in vivo growth of tumor cells. Biochem Biophys Res Commun 326: 268-273.
5. Chan BC, To KF, Pang JC, Chung YF, Lo KW, Tong JH et al. (2002). Generation of monoclonal antibodies against Hong Kong nasopharyngeal carcinoma-associated Epstein-Barr virus latent membrane protein 1 (LMP1). Int J Cancer 102: 492-498.
6. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T et al. (2001). BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8: 705-711.
7. Ching AK, Li PS, Chan WY, Ma CH, Lee SS, Lim PL et al. (2000). Strand bias in Ig somatic hypermutation is determined by signal sequence within the variable region. Int Immunol 12: 1245-1253.
8. Cory S, Huang DC, Adams JM. (2003). The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607.
9. de la Coste A, Fabre M, McDonell N, Porteu A, Gilgenkrantz H, Perret C et al. (1999a). Differential protective effects of Bcl-xL and Bcl-2 on apoptotic liver injury in transgenic mice. Am J Physiol 277: G702-G708.
10. de La Coste A, Mignon A, Fabre M, Gilbert E, Porteu A, Van Dyke T et al. (1999b). Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic mice. Cancer Res 59: 5017-5022.
11. Dive C, Evans CA, Whetton AD. (1992). Induction of apoptosis - new targets for cancer chemotherapy. Semin Cancer Biol 3: 417-427.
12. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK et al. (2003). Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell 12: 1087-1099.
13. Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R et al. (2000). Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 19: 4563-4573.
14. Green DR, Reed JC. (1998). Mitochondria and apoptosis. Science 281: 1309-1312.
15. Gross A, McDonnell JM, Korsmeyer SJ. (1999). BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911.
16. Gu C, Castellino A, Chan JY, Chao MV. (1998). BRE: a modulator of TNF-alpha action. FASEB J 12: 1101-1118.
17. Huang DC, O'Reilly LA, Strasser A, Cory S. (1997). The antiapoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J 16: 4628-4638.
18. Kohler G, Milstein C. (1975). Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495-497.
19. Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. (2000). Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 7: 1166-1173.
20. Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T et al. (1996). Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med 2: 80-86.
21. Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY. (1995). Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Biochem Biophys Res Commun 206: 764-774.
22. Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC et al. (2004). A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. J Biol Chem 279: 52106-52116.
23. Lowe SW, Cepero E, Evan G. (2004). Intrinsic tumour suppression. Nature 432: 307-315.
24. Nagata S. (1997). Apoptosis by death factor. Cell 88: 355-365.
25. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y et al. (1993). Lethal effect of the anti-Fas antibody in mice. Nature 364: 806-809.
26. O'Reilly LA, Huang DC, Strasser A. (1996). The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J 15: 6979-6990.
27. Pierce RH, Vail ME, Ralph L, Campbell JS, Fausto N. (2002). Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci. Am J Pathol 160: 1555-1560.
28. Rausa FM, Tan Y, Zhou H, Yoo KW, Stolz DB, Watkins SC et al. (2000). Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol 20: 8264-8282.
29. Rodriguez I, Matsuura K, Khatib K, Reed JC, Nagata S, Vassalli P. (1996). A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med 183: 1031-1036.
30. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ et al. (1998). Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17: 1675-1687.
31. Strasser A, Harris AW, Huang DC, Krammer PH, Cory S. (1995). Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 14: 6136-6147.
32. Tang MK, Wang CM, Shan SW, Chui YL, Ching AK, Chow PH et al. (2006). Comparative proteomic analysis reveals a function of the novel death receptor-associated protein BRE in the regulation of prohibitin and p53 expression and proliferation. Proteomics 6: 2376-2385.
33. Vail ME, Pierce RH, Fausto N. (2001). Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha. Cancer Res 61: 594-601.
34. Vaux DL, Korsmeyer SJ. (1999). Cell death in development. Cell 96: 245-254.
35. Yan C, Costa RH, Darnell Jr JE, Chen JD, Van Dyke TA. (1990). Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. EMBO J 9: 869-878.
36. Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B et al. (1999). Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400: 886-891.
37. Yu J, Hui AY, Chu ES, Cheng AS, Go MY, Chan HL et al. (2007). Expression of a COX-2 transgene in murine liver causes hepatitis. Gut 56: 991-999.
38. Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G. (1998). Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene 16: 2265-2282.
39. Zhivotovsky B, Orrenius S. (2006). Carcinogenesis and apoptosis: paradigms and paradoxes. Carcinogenesis 27: 1939-1945.