Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) - Update 2008

Ultraschall in der Medizin

Volumn 29, Issue 1, 2008, Pages 28-44

  Claudon, Michel ^a,b   Cosgrove, D ^c   Albrecht, T ^d   Bolondi, L ^e   Boslo, M ^f   Calliada, F ^g   Correas, J M ^h   Darge, K ⁱ   Dietrich, C ^j   D'Onofrio, M ^k   Evans, D H ^b   Filice, C ^l   Greiner, L ^m   Jager K ⁿ   De Jong, N ^o   Leen, E ^p   Lencioni, R ^q   Lindsell, D ^r   Martegani, A ^s   Meairs, S ^t   Nolsoe C ^u   Piscaglia, F ^v   Ricci, P ^w   Seidel, G ^x   Skjoldbye, B ^u   Solbiati, C ^y   Thorelius, L ^z   Tranquart, F ^aa   Weskott, H P ^ab   Whittingham, T ^ac   more..

^a CHU NANCY BRABOIS   (France)

^b Department of Radiology ^*  (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d HUMBOLDT UNIVERSITY   (Germany)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f Magenta Hospital   (Italy)

^g Servizio di Radiologia   (Italy)

^h HÔPITAL NECKER ENFANTS MALADES   (France)

ⁱ UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^j CARITAS KRANKENHAUS   (Germany)

^k UNIVERSITY OF VERONA   (Italy)

^l IRCCS Policlinico San Matteo Foundation   (Italy)

^m HELIOS KLINIKUM WUPPERTAL   (Germany)

ⁿ UNIVERSITY HOSPITAL BASEL   (Switzerland)

^o ERASMUS MEDICAL CENTER   (Netherlands)

^p IMPERIAL COLLEGE LONDON   (United Kingdom)

^q UNIVERSITY OF PISA   (Italy)

^r JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^s Servizio di Radiologia   (Italy)

^t UNIVERSITY OF HEIDELBERG   (Germany)

^u UNIVERSITY OF COPENHAGEN   (Denmark)

^v Internal Medicine   (Italy)

^w POLICLINICO UMBERTO I   (Italy)

^x UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^y General Hospital of Busto Arsizio   (Italy)

^z GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^aa Unité Fonctionnelle Ultrasons Directeur CIT   (France)

^ab Krankenhaus Siloah   (Germany)

^ac NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

more..

Author keywords

Contrast agent; Liver; Pancreas; Transcranial US; Trauma; Urinary; V. ureteric reflux

Indexed keywords

CONTRAST MEDIUM; SONOVUE;

ABDOMINAL BLUNT TRAUMA; CONSENSUS DEVELOPMENT; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC IMAGING; DOPPLER ECHOGRAPHY; EARLY DIAGNOSIS; ECHOGRAPHY; GOOD CLINICAL PRACTICE; HUMAN; IMAGE ANALYSIS; IMAGE DISPLAY; KIDNEY DISEASE; LIGHT SCATTERING; LIVER DISEASE; LIVER INJURY; LIVER METASTASIS; LIVER TUMOR; PANCREAS CARCINOMA; PRACTICE GUIDELINE; REVIEW; VESICOURETERAL REFLUX;

CONTRAST MEDIA; EUROPE; HUMANS; IMAGE ENHANCEMENT; KIDNEY DISEASES; KIDNEY NEOPLASMS; LIVER DISEASES; NEOPLASMS; PANCREATIC DISEASES; ULTRASONOGRAPHY;

EID: 39749095082     PISSN: 01724614     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-963785     Document Type: Review

References (143)

1. Tranquart F, Claudon M, Correas JM. Guidelines for the use of contrast agents in ultrasound. J Radiol 2005; 86: 1047-1054
2. Xiaoyan X, Guang H, Feng X et al. Focal liver lesions ultrasound contrast: the light of the European Clinical Guide. China Ultrasound Imaging Magazine 2006; 06: 1-16
3. Bauer A, Solbiati L. Ultrasound contrast agents. In: Solbiati L (ed). Contrast-enhanced ultrasound of liver diseases. Milan: Springer, 2003: 21-26
4. Burns P. Contrast ultrasound technology. In: Solbiati L (ed). Contrast-enhanced ultrasound of liver diseases. Milan: Springer, 2003: 1-18
5. Correas JM, Bridal L, Lesavre A et al. Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol 2001; 11: 1316-1328
6. Basilico R, Blomley MJ, Harvey CJ et al. Which continuous US scanning mode is optimal for the detection of vascularity in liver lesions when enhanced with a second generation contrast agent? Eur J Radiol 2002; 41: 184-191
7. Bernatik T, Becker D, Neureiter D et al. Detection of liver metastases - comparison of contrast - enhanced ultrasound using first versus second generation contrast agents. Ultraschall in Med 2003; 24: 175-179
8. Leen E, Horgan P. Ultrasound contrast agents for hepatic imaging with nonlinear modes. Curr Probl Diagn Radiol 2003; 32: 66-87
9. Averkiou M, Powers J, Skyba D et al. Ultrasound contrast imaging research. Ultrasound Q 2003; 19: 27-37
10. Burns P, Powers J, Hope Simpson D et al. Harmonic Imaging: principles and preliminary results. Angiology 1996; 47: S63-S74
11. Schrope BA, Newhouse VL. Second harmonic ultrasonic blood perfusion measurement. Ultrasound Med Biol 1993; 19: 567-579
12. Simpson DH, Chin CT, Burns PN. Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans on Ultrasonics, Ferroelectrics, and Freq Control 1999; 46: 372-382
13. Tiemann K, Lohmeier S, Kuntz S et al. Real-Time Contrast Echo Assessment of Myocardial Perfusion at Low Emission Power: First Experimental and Clinical Results Using Power Pulse Inversion Imaging. Echocardiography 1999; 16: 799-809
14. Berrocal T, Gaya F, Arjonilla A et al. Vesicoureteral reflux: diagnosis and grading with echo-enhanced cystosonography versus voiding cystourethrography. Radiology 2001; 221: 359-365
15. Darge K. Contrast-enhanced voiding urosonography for diagnosis of vesicoureteral reflux in children. Pediatr Radiol 2007; 38: 40-63
16. Darge K, Troeger J, Duetting T et al. Reflux in young patients: comparison of voiding US of the bladder and retrovesical space with echo enhancement versus voiding cystourethrography for diagnosis. Radiology 1999; 210: 201-207
17. Ascend G, Zimbaro G, Mazziotti S et al. Harmonic US imaging of vesicoureteric reflux in children: usefulness of a second generation US contrast agent. Pediatr Radiol 2004; 34: 481-487
18. Bosio M, Xhepa R, Pandolfi M. Advancements in the diagnosis of vesico-ureteral reflux with cystourethrosonography (CUS): a comparative study between 1st and 2nd generation contrast media. Pediatr Nephrol 2005; 20: C95
19. Darge K, Beer M, Gordjani N et al. Contrast-enhanced voiding urosonography with the use of a 2nd generation US contrast medicum: preliminary results. Pediatr Radiol 2004; 34: S97
20. Papadopoulou F, Katzioti F, Arkoumani E et al. Voiding urosonography harmonic imaging with 2nd generation contrast agent for the diagnosis of reflux. Pediatr Radiol 2005; 35: S31
21. Rehman S, Jayson GC. Molecular imaging of antiangiogenic agents. Oncologist 2005; 10: 92-103
22. Therasse P, Arbuck SG, Eisenhauer EA et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-216
23. World Health Organisation Offset Publication e. WHO Handbook for Reporting Results of Cancer Treatment Geneva, Switzerland, 1979
24. De Giorgi U, Aliberti C, Benea G et al. Effect of angiosonography to monitor response during imatinib treatment in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res 2005; 11: 6171-6176
25. Lassau N, Lamuraglia M, Leclere J et al. Functional and early evaluation of treatments in oncology: interest of ultrasonographic contrast agents. J Radiol 2004; 85: 704-712
26. Lassau N, Lamuraglia M, Chami L et al. Gastrointestinal stromal tumors treated with imatinib: monitoring response with contrast-enhanced sonography. AJR Am J Roentgenol 2006; 187: 1267-1273
27. Education and Practical Standards Committee, European Federation of Societies for Ultrasound in Medicine and Biology. Minimum training recommendations for the practice of medical ultrasound. Ultraschall in Med 2006; 27: 79-105
28. Piscaglia F, Bolondi L. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 2006; 32: 1369-1375
29. Blomley M, Claudon M, Cosgrove D. WFUMB Safety Symposium on Ultrasound Contrast Agents: clinical applications and safety concerns. Ultrasound Med Biol 2007; 33: 180-186
30. Barnett SB, Duck F, Ziskin M. Recommendations on the safe use of ultrasound contrast agents. Ultrasound Med Biol 2007; 33: 173-174
31. Vancraeynest D, Kefer J, Hanet C et al. Release of cardiac bio-markers during high mechanical index contrast-enhanced echocardiography in humans. Eur Heart J 2007; 28: 1236-1241
32. Kono Y, Steinbach GC, Peterson T et al. Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: an intravital microscopy study in rats. Radiology 2002; 224: 253-257
33. Yanagisawa K, Moriyasu F, Miyahara T et al. Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol 2007; 33: 318-325
34. Albrecht T, Blomley MJ, Heckemann RA et al. Stimulated acoustic emissions with the ultrasound contrast medium levovist: a clinically useful contrast effect with liver-specific properties. Fortschr Röntgenstr 2000; 172: 61-67
35. Blomley MJ, Sidhu PS, Cosgrove DO et al. Do different types of liver lesions differ in their uptake of the microbubble contrast agent SH U508A in the late liver phase? Early experience. Radiology 2001; 220: 661-667
36. Bryant TH, Blomley MJ, Albrecht T et al. Improved characterization of liver lesions with liver-phase uptake of liver-specific microbubbles: prospective multicenter study. Radiology 2004; 232: 799-809
37. Catala V, Nicolau C, Vilana R et al. Characterization of focal liver lesions: comparative study of contrast-enhanced ultrasound versus spiral computed tomography. Eur Radiol 2007; 17: 1066-1073
38. Dietrich C, Ignee A, Trojan J et al. Improved characterisation of histologically proven liver tumours by contrast enhanced ultrasonography during the portal venous and specific late phase of SHU 508A. Gut 2004; 53: 401-405
39. Dietrich CF, Ignee A, Frey H. Contrast-enhanced endoscopic ultrasound with low mechanical index: a new technique. Z Gastroenterol 2005; 43: 1219-1223
40. Dietrich CF, Mertens JC, Braden B et al. Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology 2007; 45: 1139-1145
41. Dill-Macky MJ, Burns PN, Khalili K et al. Focal hepatic masses: enhancement patterns with SH U 508A and pulse-inversion US. Radiology 2002; 222: 95-102
42. Ding H, Wang WP, Huang BJ et al. Imaging of focal liver lesions: low-mechanical-index real-time ultrasonography with SonoVue. J Ultrasound Med 2005; 24: 285-297
43. Fan ZH, Chen MH, Dai Y et al. Evaluation of primary malignancies of the liver using contrast-enhanced sonography: correlation with pathology. AJR Am J Roentgenol 2006; 186: 1512-1519
44. Kim SH, Lee JM, Lee JY et al. Value of contrast-enhanced sonography for the characterization of focal hepatic lesions in patients with diffuse liver disease: receiver operating characteristic analysis. AJR Am J Roentgenol 2005; 184: 1077-1084
45. Leen E, Ceccotti P, Kalogeropoulou C et al. Prospective multicenter trial evaluating a novel method of characterizing focal liver lesions using contrast-enhanced sonography. AJR Am J Roentgenol 2006; 186: 1551-1559
46. Mork H, Zgnee A, Schuessler G et al. Analysis of neuroendocrine tumour metastases in the liver using contrast enhanced ultrasonography. Scand J Gastroenterol 2007; 42: 652-662
47. Nicolau C, Vilana R, Catala V et al. Importance of evaluating all vascular phases on contrast-enhanced sonography in the differentiation of benign from malignant focal liver lesions. AJR Am J Roentgenol 2006; 186: 158-167
48. Quaia E, Degobbis F, Tona G et al. Differential patterns of contrast enhancement in different focal liver lesions after injection of the microbubble US contrast agent SonoVue. Radiol Med (Torino) 2004; 107: 155-165
49. Quaia E, Stacul F, Bertolotto M et al. Characterization of focal liver lesions with pulse inversion harmonic imaging (PIHI) using a second generation US contrast agent. Acad Radiol 2002; 9 (Suppl 2): S376-379
50. Ricci P, Laghi A, Cantisani V et al. Contrast-enhanced sonography with SonoVue: enhancement patterns of benign focal liver lesions and correlation with dynamic gadobenate dimeglumine-enhanced MRI. AJR Am J Roentgenol 2005; 184: 821-827
51. Strobel D, Hoefer A, Martus P et al. Dynamic contrast-enhanced power Doppler sonography improves the differential diagnosis of liver lesions. Int J Colorectal Dis 2001; 16: 247-256
52. von Herbay A, Vogt C, Willers R et al. Real-time imaging with the sonographic contrast agent SonoVue: differentiation between benign and malignant hepatic lesions. J Ultrasound Med 2004; 23: 1557-1568
53. Wilson SR, Burns PN. An algorithm for the diagnosis of focal liver masses using microbubble contrast-enhanced pulse-inversion sonography. AJR Am J Roentgenol 2006; 186: 1401-1412
54. Wilson SR, Burns PN, Muradali D et al. Harmonic hepatic US with microbubble contrast agent: initial experience showing improved characterization of hemangioma, hepatocellular carcinoma, and metastasis. Radiology 2000; 215: 153-161
55. Xu HX, Liu GJ, Lu MD et al. Characterization of small focal liver lesions using real-time contrast-enhanced sonography: diagnostic performance analysis in 200 patients. J Ultrasound Med 2006; 25: 349-361
56. Xu HX, Lu MD, Liu GJ et al. Imaging of peripheral cholangiocarcinoma with low-mechanical index contrast-enhanced sonography and SonoVue: initial experience. J Ultrasound Med 2006; 25: 23-33
57. Bolondi L, Gaiani S, Celli N et al. Characterization of small nodules in cirrhosis by assessment of vascularity: the problem of hypovascular hepatocellular carcinoma. Hepatology 2005; 42: 27-34
58. Celli N, Gaiani S, Piscaglia F et al. Characterization of liver lesions by real-time contrast-enhanced ultrasonography. Eur J Gastroenterol Hepatol 2007; 19: 3-14
59. Gaiani S, Celli N, Piscaglia F et al. Usefulness of contrast-enhanced perfusional sonography in the assessment of hepatocellular carcinoma hypervascular at spiral computed tomography. J Hepatol 2004; 41: 421-426
60. Tarantino L, Francica G, Sordelli I et al. Diagnosis of benign and malignant portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma: color Doppler US, contrast-enhanced US, and fine-needle biopsy. Abdom Imaging 2006; 31: 537-544
61. Venturi A, Piscaglia F, Silvagni E et al. Role of real-time contrast-enhanced ultrasound in the assessment of metastatic portal vein thrombosis. Ultraschall in Med 2007; 28: 75-78
62. Beissert M, Jenett M, Keberle M et al. Comparison of contrast harmonic imaging in B-mode with stimulated acoustic emission, conventional B-mode US and spiral CT in the detection of focal liver lesions. Fortschr Röntgenstr 2000; 172: 361-366
63. Konopke R, Kersting S, Bergert H et al. Contrast-enhanced ultrasonography to detect liver metastases: A prospective trial to compare transcutaneous unenhanced and contrast-enhanced ultrasonography in patients undergoing laparotomy. Int J Colorectal Dis 2007; 22: 201-207
64. Piscaglia F, Corradi F, Mancini M et al. Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer. BMC Cancer 2007; 7: 171
65. Albrecht T, Blomley MJ, Burns PN et al. Improved detection of hepatic metastases with pulse-inversion US during the liver-specific phase of SHU 508A: multicenter study. Radiology 2003; 227: 361-370
66. Dietrich CF, Kratzer W, Strobe D et al. Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol 2006; 12: 1699-1705
67. Harvey CJ, Blomley MJ, Eckersley RJ et al. Hepatic malignancies: improved detection with pulse-inversion US in late phase of enhancement with SH U508A-early experience. Radiology 2000; 216: 903-908
68. Hohmann J, Albrecht T, Hoffmann CW et al. Ultrasonographic detection of focal liver lesions: increased sensitivity and specificity with microbubble contrast agents. Eur J Radiol 2003; 46: 147-159
69. Leen E, Ceccotti P, Moug SJ et al. Potential value of contrast-enhanced intraoperative ultrasonography during partial hepatectomy for metastases: an essential investigation before resection? Ann Surg 2006; 243: 236-240
70. Torzilli G, Del Fabbro D, Palmisano A et al. Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases. J Gastrointest Surg 2005; 9: 1148-1153; discussion 1153-1144
71. Livraghi T, Goldberg SN, Lazzaroni S et al. Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 2000; 214: 761-768
72. Livraghi T, Goldberg SN, Solbiati L et al. Percutaneous radio-frequency ablation of liver metastases from breast cancer: initial experience in 24 patients. Radiology 2001; 220: 145-149
73. Oshowo A, Gillams A, Harrison E et al. Comparison of resection and radiofrequency ablation for treatment of solitary colorectal liver metastases. Br J Surg 2003; 90: 1240-1243
74. Raut CP, Izzo F, Marra P et al. Significant long-term survival after radiofrequency ablation of unresectable hepatocellular carcinoma in patients with cirrhosis. Ann Surg Oncol 2005; 12: 616-628
75. Rossi S, Di Stasi M, Buscarini E et al. Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. AJR Am J Roentgenol 1996; 167: 759-768
76. Solbiati L, Livraghi T, Goldberg SN et al. Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology 2001; 221: 159-166
77. Tateishi R, Shiina S, Teratani T et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases. Cancer 2005; 103: 1201-1209
78. Choi D, Lim HK, Lee WJ et al. Early assessment of the therapeutic response to radio frequency ablation for hepatocellular carcinoma: utility of gray scale harmonic ultrasonography with a microbubble contrast agent. J Ultrasound Med 2003; 22: 1163-1172
79. Cioni D, Lencioni R, Rossi S et al. Radiofrequency thermal ablation of hepatocellular carcinoma: using contrast-enhanced harmonic power Doppler sonography to assess treatment outcome. AJR Am J Roentgenol 2001; 177: 783-788
80. Cova L, Solbiati L, Lerace T. Usefulness of contrast-enhanced ultrasonography and real-time low mechanical index harmonic imaging in the selection and monitoring of patients undergoing percutaneous radiofrequency thermal ablation of liver tumors. Eur Radiol 2003; 13: S124
81. Dill-Macky MJ, Asch M, Burns P et al. Radiofrequency ablation of hepatocellular carcinoma: predicting success using contrast-enhanced sonography. AJR Am J Roentgenol 2006; 186: S287-295
82. Minami Y, Kudo M, Kawasaki T et al. Treatment of hepatocellular carcinoma with percutaneous radiofrequency ablation: usefulness of contrast harmonic sonography for lesions poorly defined with B-mode sonography. AJR Am J Roentgenol 2004; 183: 153-156
83. Morimoto M, Nozawa A, Numata K et al. Evaluation using contrast-enhanced harmonic gray scale sonography after radio frequency ablation of small hepatocellular carcinoma: sonographic-histopathologic correlation. J Ultrasound Med 2005; 24: 273-283
84. Rhim H, Goldberg SN, Dodd GD et al. Essential techniques for successful radio-frequency thermal ablation of malignant hepatic tumors. Radiographics 2001; 21 (Suppt 1): S17-S35; discussion S36-S19
85. Solbiati L, Tonolini M, Lerace T. Guidance of percutaneous tumor ablation. In: Lencioni R (ed). Enhancing the role of ultrasound with contarst agents. Heildelberg: Springer, 2006: 69-76
86. Chen MH, Yang W, Yan K et al. Large liver tumors: protocol for radiofrequency ablation and its clinical application in 110 patients - mathematic model, overlapping mode, and electrode placement process. Radiology 2004; 232: 260-271
87. Liu Z, Lobo SM, Humphries S et al. Radiofrequency tumor ablation: insight into improved efficacy using computer modeling. AJR Am J Roentgenol 2005; 184: 1347-1352
88. Sasaki A, Kai S, Iwashita Y et al. Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma. Cancer 2005; 103: 299-306
89. Schmidt T, Hohl C, Hoage P et al. Diagnostic accuracy of phase-inversion tissue harmonic imaging versus fundamental B-mode sonography in the evaluation of focal lesions of the kidney. AJR Am J Roentgenol 2003; 180: 1639-1647
90. Robbin ML, Lockhart ME, Barr RG. Renal imaging with ultrasound contrast: current status. Radiol Clin North Am 2003; 41: 963-978
91. Ascenti G, Zimbaro G, Mazziotti S et al. Usefulness of power Doppler and contrast-enhanced sonography in the differentiation of hyperechoic renal masses. Abdom Imaging 2001; 26: 654-660
92. Kim B, Lim HK, Choi MH et al. Detection of parenchymal abnormalities in acute pyelonephritis by pulse inversion harmonic imaging with or without microbubble ultrasonographic contrast agent: correlation with computed tomography. J Ultrasound Med 2001; 20: 5-14
93. Israel GM, Bosniak MA. An update of the Bosniak renal cyst classification system. Urology 2005; 66: 484-488
94. Kim AY, Kim SH, Kim YJ et al. Contrast-enhanced power Doppler sonography for the differentiation of cystic renal lesions: preliminary study. J Ultrasound Med 1999; 18: 581-588
95. Claudon M, Barnewolt CE, Taylor GA et al. Renal blood flow in pigs: changes depicted with contrast-enhanced harmonic US imaging during acute urinary obstruction. Radiology 1999; 212: 725-731
96. Claudon M, Plouin PF, Baxter GM et al. Renal arteries in patients at risk of renal arterial stenosis: multicenter evaluation of the echo-enhancer SH U508A at color and spectral Doppler US. Levovist Renal Artery Stenosis Study Group. Radiology 2000; 214: 739-746
97. Lencioni R, Pinto S, Cioni D et al. Contrast-Enhanced Doppler Ultrasound of Renal Artery Stenosis: Prologue to a Promising Future. Echocardiography 1999; 16: 767-773
98. Melany ML, Grant EG, Duerinckx AJ et al. Ability of a phase shift US contrast agent to improve imaging of the main renal arteries. Radiology 1997; 205: 147-152
99. Correas J, Helenen O, Moreau JF. Contrast-enhanced ultrasonography of native and transplanted kidney diseases. Eur Radiol 1999; 9 Suppl 3: S394-400
100. Schmiedl UP, Carter S, Martin RW et al. Sonographic detection of acute parenchymal injury in an experimental porcine model of renal hemorrhage: gray-scale imaging using a sonographic contrast agent. AJR Am J Roentgenol 1999; 173: 1289-1294
101. Yamakado K, Tanaka N, Nakagawa T et al. Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture. Radiology 2002; 225: 78-82
102. Bosio M. Cystosonography with echocontrast: a new imaging modality to detect vesicoureteric reflux in children. Pediatr Radiol 1998; 28: 250-255
103. Galloy MA, Mandry D, Pecastaings M et al. Sonocystography: a new method for the diagnosis and follow-up of vesico-ureteric reflux in children. J Radiol 2003; 84: 2055-2061
104. Kenda RB, Novljan G, Kenig A et al. Echo-enhanced ultrasound voiding cystography in children: a new approach. Pediatr Nephrol 2000; 14: 297-300
105. Mentzel HJ, Vogt S, Patzer L et al. Contrast-enhanced sonography of vesicoureterorenal reflux in children: preliminary results. AJR Am J Roentgenol 1999; 173: 737-740
106. Radmayr C, Klauser A, Pallwein L et al. Contrast enhanced reflux sonography in children: a comparison to standard radiological imaging. J Urol 2002; 167: 1428-1430
107. Uhl M, Kromeier J, Zimmerhackl LB et al. Simultaneous voiding cystourethrography and voiding urosonography. Acta Radiol 2003; 44: 265-268
108. Valentini AL, De Gaetano AM, Destito C et al. The accuracy of voiding urosonography in detecting vesico-ureteral reflux: a summary of existing data. Eur J Pediatr 2002; 161: 380-384
109. Vassiou K, Vlychou M, Moisidou R et al. Contrast-enhanced sonographic detection of vesicoureteral reflux in children: comparison with voiding cystourethrography. Röntgenstr Fortschr 2004; 176: 1453-1457
110. Darge K, Ghods S, Zieger B et al. Reduction in voiding cystourethrographies after the introduction of contrast enhanced sonographic reflux diagnosis. Pediatr Radiol 2001; 31: 790-795
111. Nakamura M, Shinozaki T, Taniguchi N et al. Simultaneous voiding cystourethrography and voiding urosonography reveals utility of sonographic diagnosis of vesicoureteral reflux in children. Acta Paediatr 2003; 92: 1422-1426
112. Galia M, Midiri M, Pennisi F et al. Vesicoureteral reflux in young patients: comparison of voiding color Doppler US with echo enhancement versus voiding cystourethrography for diagnosis or exclusion. Abdom Imaging 2004; 29: 303-308
113. Riccabona M, Mache CJ, Lindbichler F. Echo-enhanced color Doppler cystosonography of vesicoureteral reflux in children. Improvement by stimulated acoustic emission. Acta Radiol 2003; 44: 18-23
114. Darge K, Trusen A, Gordjani N et al. Intrarenal reflux: diagnosis with contrast-enhanced harmonic US. Pediatr Radiol 2003; 33: 729-731
115. Darge K, Zieger B, Rohrschneider W et al. Contrast-enhanced harmonic imaging for the diagnosis of vesicoureteral reflux in pediatric patients. AJR Am J Roentgenol 2001; 177: 1411-1415
116. Kopitzko A, Cornely D, Reither K et al. Low contrast dose voiding urosonography in children with phase inversion imaging. Eur Radiol 2004; 14: 2290-2296
117. Darge K, Bruchelt W, Roessling G et al. Interaction of normal saline solution with ultrasound contrast medium: significant implication for sonographic diagnosis of vesicoureteral reflux. Eur Radiol 2003; 13: 213-218
118. Berrocal T, Gaya F, Arjonilla A. Vesicoureteral reflux: can the urethra be adequately assessed by using contrast-enhanced voiding US of the bladder? Radiology 2005; 234: 235-241
119. Bosio M, Manzoni GA. Detection of posterior urethral valves with voiding cystourethrosonography with echo contrast. J Urol 2002; 168: 1711-1715; discussion 1715
120. Mate A, Bargiela A, Mosteiro S et al. Contrast ultrasound of the urethra in children. Eur Radiol 2003; 13: 1534-1537
121. Darge K, Troeger J. Vesicoureteral reflux grading in contrast-enhanced voiding urosonography. Eur J Radiol 2002; 43: 122-128
122. Kenda RB. Imaging techniques for the detection of vesicoureteric reflux: what and when? Nephrol Dial Transplant 2001; 16: 4-7
123. Riccabona M. Cystography in infants and children: a critical appraisal of the many forms with special regard to voiding cystourethrography. Eur Radiol 2002; 12: 2910-2918
124. D'Onofrio M, Mansueto G, Falconi M et al. Neuroendocrine pancreatic tumor: value of contrast enhanced ultrasonography. Abdom Imaging 2004; 29: 246-258
125. D'Onofrio M, Zamboni G, Faccioli N et al. Ultrasonography of the pancreas. 4. Contrast-enhanced imaging. Abdom Imaging 2007; 32: 171-181
126. D'Onofrio M, Zamboni G, Malago R et al. Pancreatic pathology. In: Quaia E (ed). Contrast media in ultrasonography. Berlin: Springer-Verlag, 2005: 335-247
127. Dietrich CF, Braden B, Hocke M et al. Improved characterisation of solitary solid pancreatic tumours using contrast enhanced transabdominal ultrasound. J Cancer Res Clin Oncol 2007 (in press)
128. D'Onofrio M, Martone E, Faccioli N et al. Focal liver lesions: sinusoidal phase of CEUS. Abdom Imaging 2006; 31: 529-536
129. D'Onofrio M, Rozzanigo U, Masinielli BM et al. Hypoechoic focal liver lesions: characterization with contrast enhanced ultrasonography. J Clin Ultrasound 2005; 33: 164-172
130. Quaia E, D'Onofrio M, Palumbo A et al. Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence. Eur Radiol 2006; 16: 1599-1609
131. Solbiati L, Tonolini M, Cova L et al. The role of contrast-enhanced ultrasound in the detection of focal liver leasions. Eur Radiol 2001; 11 (Suppl 3): E15-E26
132. D'Onofrio M, Malago R, Zamboni G et al. Contrast-enhanced ultrasonography better identifies pancreatic tumor vascularization than helical CT. Pancreatology 2005; 5: 398-402
133. D'Onofrio M, Zamboni G, Tognolini A et al. Mass-forming pancreatitis: value of contrast-enhanced ultrasonography. World J Gastroenterol 2006; 12: 4181-4184
134. Hocke M, Schulze E, Gottschalk P et al. Contrast-enhanced endoscopic ultrasound in discrimination between focal pancreatitis and pancreatic cancer. World J Gastroenterol 2006; 12: 246-250
135. Kitano M, Kudo M, Maekawa K et al. Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography. Gut 2004; 53: 854-859
136. Masaki T, Ohkawa S, Amano A et al. Noninvasive assessment of tumor vascularity by contrast-enhanced ultrasonography and the prognosis of patients with nonresectable pancreatic carcinoma. Cancer 2005; 103: 1026-1035
137. Numata K, Ozawa Y, Kobayashi N et al. Contrast-enhanced sonography of pancreatic carcinoma: correlations with pathological findings. J Gastroenterol 2005; 40: 631-640
138. Rickes S, Wermke W. Differentiation of cystic pancreatic neoplasms and pseudocysts by conventional and echo-enhanced ultrasound. J Gastroenterol Hepatol 2004; 19: 761-766
139. Takeshima K, Kumada T, Toyoda H et al. Comparison of IV contrast-enhanced sonography and histopathology of pancreatic cancer. AJR Am J Roentgenol 2005; 185: 1193-1200
140. Nagase M, Furuse J, Ishii H et al. Evaluation of contrast enhancement patterns in pancreatic tumors by coded harmonic sonographic imaging with a microbubble contrast agent. J Ultrasound Med 2003; 22: 789-795
141. D'Onofrio M, Megibow AJ, Faccioli N et al. Comparison of contrast-enhanced sonography and MRI in displaying anatomic features of cystic pancreatic masses. AJR Am J Roentgenol 2007; 189: 1435-1442
142. Khan HG, Gailloud P, Bude RO et al. The effect of contrast material on transcranial Doppler evaluation of normal middle cerebral artery peak systolic velocity. AJNR Am J Neuroradiol 2000; 21: 386-390
143. Seidel G, Kaps M. Harmonic imaging of the vertebrobasilar system. Stroke 1997; 28: 1610-1613