Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line, but not through the peroxisome proliferator-activated receptor-γ pathway

Life Sciences

Volumn 82, Issue 11-12, 2008, Pages 561-569

  Hung, Shao Hung ^a,b   Yeh, Ching Hua ^a   Huang, Hsuan Ti ^a   Wu, Peihua ^a   Ho, Mei Ling ^a   Chen, Chung Hwan ^a   Wang, Chihuei ^a   Chao, David ^b   Wang, Gwo Jaw ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Adiopocytes; Adipogenesis; cDNA microarray; Dexamethasone; Glucocorticoid receptor; Mifepristone; Osteoblasts; Peroxisome proliferator activated receptor ; Pioglitazone

Indexed keywords

2,2 BIS(4 GLYCIDYLOXYPHENYL)PROPANE; 4,4' ISOPROPYLIDENEDIPHENOL; ALKALINE PHOSPHATASE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PIOGLITAZONE; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DNA MICROARRAY; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PLURIPOTENT STEM CELL; RECEPTOR UPREGULATION; REPORTER GENE;

ADIPOGENESIS; ANIMALS; BONE MARROW CELLS; CELL LINE; CELL LINEAGE; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, REPORTER; GLUCOCORTICOIDS; HORMONE ANTAGONISTS; HYPOGLYCEMIC AGENTS; MICE; MICE, INBRED BALB C; MIFEPRISTONE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLURIPOTENT STEM CELLS; PPAR GAMMA; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; STROMAL CELLS; THIAZOLIDINEDIONES;

EID: 39649125175     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.11.033     Document Type: Article

References (35)

1. Ali A.A., Weinstein R.S., Stewart S.A., Parfitt A.M., Manolagas S.C., and Jilka R.L. Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146 (2005) 1226-1235
2. Bellows C.G., Aubin J.E., and Heersche J.N. Physiological concentrations of glucocorticoids stimulate formation of bone nodules from isolated rat calvaria cells in vitro. Endocrinology 121 (1987) 1985-1992
3. Bennett J.H., Joyner C.J., Triffitt J.T., and Owen M.E. Adipocytic cells cultured from marrow have osteogenic potential. Journal of Cell Science 99 Pt 1 (1991) 131-139
4. Bennett C.N., Longo K.A., Wright W.S., Suva L.J., Lane T.F., Hankenson K.D., and MacDougald O.A. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 3324-3329
5. Beresford J.N., Bennett J.H., Devlin C., Leboy P.S., and Owen M.E. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. Journal of Cell Science 102 Pt 2 (1992) 341-351
6. Canalis E. Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. Journal of Clinical Endocrinology and Metabolism 81 (1996) 3441-3447
7. Compston J.E., Greer S., Skingle S.J., Stirling D.M., Price C., Friend P.J., and Alexander G. Early increase in plasma parathyroid hormone levels following liver transplantation. Journal of Hepatology 25 (1996) 715-718
8. Cui Q., Wang G.J., and Balian G. Steroid-induced adipogenesis in a pluripotential cell line from bone marrow. Journal of Bone and Joint Surgery. American Volume 79 (1997) 1054-1063
9. Ding J., Nagai K., and Woo J.T. Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow. Bioscience, Biotechnology, and Biochemistry 67 (2003) 314-321
10. Gimble J.M., and Nuttall M.E. Bone and fat: old questions, new insights. Endocrine 23 (2004) 183-188
11. Gulko P.S., and Mulloy A.L. Glucocorticoid-induced osteoporosis: pathogenesis, prevention and treatment. Clinical and Experimental Rheumatology 14 (1996) 199-206
12. Hausman G.J. Dexamethasone induced preadipocyte recruitment and expression of CCAAT/enhancing binding protein alpha and peroxisome proliferator activated receptor-gamma proteins in porcine stromal-vascular (S-V) cell cultures obtained before and after the onset of fetal adipogenesis. General and Comparative Endocrinology 133 (2003) 61-70
13. Ishida Y., and Heersche J.N. Glucocorticoid-induced osteoporosis: both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation. Journal of Bone and Mineral Research 13 (1998) 1822-1826
14. Kim S.W., Her S.J., Kim S.Y., and Shin C.S. Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts. Biochemical and Biophysical Research Communications 327 (2005) 811-819
15. Kim J., Temple K.A., Jones S.A., Meredith K.N., Basko J.L., and Brady M.J. Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels. Journal of Biological Chemistry 282 (2007) 11038-11046
16. Kodama H.A., Amagai Y., Koyama H., and Kasai S. Hormonal responsiveness of a preadipose cell line derived from newborn mouse calvaria. Journal of Cellular Physiology 112 (1982) 83-88
17. Lazarenko O.P., Rzonca S.O., Hogue W.R., Swain F.L., Suva L.J., and Lecka-Czernik B. Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone. Endocrinology 148 (2007) 2669-2680
18. Leboy P.S., Beresford J.N., Devlin C., and Owen M.E. Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures. Journal of Cellular Physiology 146 (1991) 370-378
19. Lecka-Czernik B., Gubrij I., Moerman E.J., Kajkenova O., Lipschitz D.A., Manolagas S.C., and Jilka R.L. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. Journal of Cellular Biochemistry 74 (1999) 357-371
20. Lecka-Czernik B., Moerman E.J., Grant D.F., Lehmann J.M., Manolagas S.C., and Jilka R.L. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 143 (2002) 2376-2384
21. Lemberger T., Staels B., Saladin R., Desvergne B., Auwerx J., and Wahli W. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. Journal of Biological Chemistry 269 (1994) 24527-24530
22. Martin R.B., Chow B.D., and Lucas P.A. Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs. Calcified Tissue International 46 (1990) 189-194
23. Meunier P., Aaron J., Edouard C., and Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clinical Orthopaedics and Related Research 80 (1971) 147-154
24. Minaire P., Neunier P., Edouard C., Bernard J., Courpron P., and Bourret J. Quantitative histological data on disuse osteoporosis: comparison with biological data. Calcified Tissue Research 17 (1974) 57-73
25. Nuttall M.E., and Gimble J.M. Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?. Bone 27 (2000) 177-184
26. Nuttall M.E., Patton A.J., Olivera D.L., Nadeau D.P., and Gowen M. Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders. Journal of Bone and Mineral Research 13 (1998) 371-382
27. Rozman C., Feliu E., Berga L., Reverter J.C., Climent C., and Ferran M.J. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Experimental Hematology 17 (1989) 34-37
28. Shalhoub V., Conlon D., Tassinari M., Quinn C., Partridge N., Stein G.S., and Lian J.B. Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes. Journal of Cellular Biochemistry 50 (1992) 425-440
29. Sottile V., Seuwen K., and Kneissel M. Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone). Calcified Tissue International 75 (2004) 329-337
30. Tontonoz P., Hu E., and Spiegelman B.M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79 (1994) 1147-1156
31. Wang G.J., Sweet D.E., Reger S.I., and Thompson R.C. Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. Journal of Bone and Joint Surgery. American Volume 59 (1977) 729-735
32. Wang G.J., Cui Q., and Balian G. The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis. Clinical Orthopaedics and Related Research (2000) 295-310
33. Wright H.M., Clish C.B., Mikami T., Hauser S., Yanagi K., Hiramatsu R., Serhan C.N., and Spiegelman B.M. A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. Journal of Biological Chemistry 275 (2000) 1873-1877
34. Wronski T.J., Walsh C.C., and Ignaszewski L.A. Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats. Bone 7 (1986) 119-123
35. Yin L., Li Y.B., and Wang Y.S. Dexamethasone-induced adipogenesis in primary marrow stromal cell cultures: mechanism of steroid-induced osteonecrosis. Chinese Medical Journal 119 (2006) 581-588