Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors

FEBS Letters

Volumn 582, Issue 5, 2008, Pages 792-798

  Chiu, Pei Ling ^a   Ng, Boon Han ^b   Chang, Gin Wen ^c   Gordon, Siamon ^c   Lin, Hsi Hsien ^b  

^a University College of Medicine   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Adhesion GPCR; Alternative splicing; EGF TM7; LNB TM7; trans Splicing

Indexed keywords

CD97 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; CHIMERA; CONTROLLED STUDY; EXON; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANS SPLICING;

ALTERNATIVE SPLICING; ANTIGENS, CD; BASE SEQUENCE; CELL LINE; CLONE CELLS; COMPUTATIONAL BIOLOGY; EXONS; EXPRESSED SEQUENCE TAGS; HUMANS; INTRONS; LIGANDS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LEUKOCYTE-ADHESION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PRECURSORS; RNA, MESSENGER;

EID: 39649121700     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.02.004     Document Type: Article

References (50)

1. Pennisi E. Human genome project. And the gene number is?. Science 288 (2000) 1146-1147
2. Cheng J., et al. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Science 308 (2005) 1149-1154
3. Black D.L. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell 103 (2000) 367-370
4. Graveley B.R. Alternative splicing: increasing diversity in the proteomic world. Trends Genet. 17 (2001) 100-107
5. Maniatis T., and Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418 (2002) 236-243
6. Modrek B., and Lee C. A genomic view of alternative splicing. Nat. Genet. 30 (2002) 13-19
7. Sorek R., and Amitai M. Piecing together the significance of splicing. Nat. Biotechnol. 19 (2001) 196
8. Horiuchi T., and Aigaki T. Alternative trans-splicing: a novel mode of pre-mRNA processing. Biol. Cell 98 (2006) 135-140
9. Nilsen T.W. Evolutionary origin of SL-addition trans-splicing: still an enigma. Trends Genet. 17 (2001) 678-680
10. Blumenthal T. Trans-splicing and polycistronic transcription in Caenorhabditis elegans. Trends Genet. 11 (1995) 132-136
11. Dorn R., and Krauss V. The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing. Genetica 117 (2003) 165-177
12. Dorn R., Reuter G., and Loewendorf A. Transgene analysis proves mRNA trans-splicing at the complex mod(mdg4) locus in Drosophila. Proc. Natl. Acad. Sci. USA 98 (2001) 9724-9729
13. Goeke S., Greene E.A., Grant P.K., Gates M.A., Crowner D., Aigaki T., and Giniger E. Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila. Nat. Neurosci. 6 (2003) 917-924
14. Horiuchi T., Giniger E., and Aigaki T. Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Genes Dev. 17 (2003) 2496-2501
15. Eul J., Graessmann M., and Graessmann A. Experimental evidence for RNA trans-splicing in mammalian cells. Embo J. 14 (1995) 3226-3235
16. Konarska M.M., Padgett R.A., and Sharp P.A. Trans splicing of mRNA precursors in vitro. Cell 42 (1985) 165-171
17. Solnick D. Trans splicing of mRNA precursors. Cell 42 (1985) 157-164
18. Caudevilla C., Da Silva-Azevedo L., Berg B., Guhl E., Graessmann M., and Graessmann A. Heterologous HIV-nef mRNA trans-splicing: a new principle how mammalian cells generate hybrid mRNA and protein molecules. FEBS Lett. 507 (2001) 269-279
19. Caudevilla C., Serra D., Miliar A., Codony C., Asins G., Bach M., and Hegardt F.G. Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver. Proc. Natl. Acad. Sci. USA 95 (1998) 12185-12190
20. Frantz S.A., Thiara A.S., Lodwick D., Ng L.L., Eperon I.C., and Samani N.J. Exon repetition in mRNA. Proc. Natl. Acad. Sci. USA 96 (1999) 5400-5405
21. Akopian A.N., Okuse K., Souslova V., England S., Ogata N., and Wood J.N. Trans-splicing of a voltage-gated sodium channel is regulated by nerve growth factor. FEBS Lett. 445 (1999) 177-182
22. Flouriot G., Brand H., Seraphin B., and Gannon F. Natural trans-spliced mRNAs are generated from the human estrogen receptor-alpha (hER alpha) gene. J. Biol. Chem. 277 (2002) 26244-26251
23. Finta C., and Zaphiropoulos P.G. Intergenic mRNA molecules resulting from trans-splicing. J. Biol. Chem. 277 (2002) 5882-5890
24. Li B.L., et al. Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. J. Biol. Chem. 274 (1999) 11060-11071
25. Tasic B., et al. Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Mol. Cell 10 (2002) 21-33
26. Fitzgerald C., Sikora C., Lawson V., Dong K., Cheng M., Oko R., and van der Hoorn F.A. Mammalian transcription in support of hybrid mRNA and protein synthesis in testis and lung. J. Biol. Chem. 281 (2006) 38172-38180
27. Coady T.H., Shababi M., Tullis G.E., and Lorson C.L. Restoration of SMN function: delivery of a trans-splicing RNA re-directs SMN2 pre-mRNA splicing. Mol. Ther. 15 (2007) 1471-1478
28. Wood M., Yin H., and McClorey G. Modulating the expression of disease genes with RNA-based therapy. PLoS Genet. 3 (2007) e109
29. McKnight A.J., and Gordon S. EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte cell-surface molecules. Immunol. Today 17 (1996) 283-287
30. McKnight A.J., and Gordon S. The EGF-TM7 family: unusual structures at the leukocyte surface. J. Leukoc. Biol. 63 (1998) 271-280
31. Fredriksson R., Gloriam D.E., Hoglund P.J., Lagerstrom M.C., and Schioth H.B. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun. 301 (2003) 725-734
32. Stacey M., Lin H.H., Gordon S., and McKnight A.J. LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors. Trends Biochem. Sci. 25 (2000) 284-289
33. Kwakkenbos M.J., Kop E.N., Stacey M., Matmati M., Gordon S., Lin H.H., and Hamann J. The EGF-TM7 family: a postgenomic view. Immunogenetics 55 (2004) 655-666
34. Hamann J., Hartmann E., and van Lier R.A. Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. Genomics 32 (1996) 144-147
35. Kwakkenbos M.J., et al. An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. Faseb J. 20 (2006) 2582-2584
36. Lin H.H., Stacey M., Hamann J., Gordon S., and McKnight A.J. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics 67 (2000) 188-200
37. Gray J.X., et al. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J. Immunol. 157 (1996) 5438-5447
38. Hamann J., et al. Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. J. Immunol. 155 (1995) 1942-1950
39. Hamann J., Stortelers C., Kiss-Toth E., Vogel B., Eichler W., and van Lier R.A. Characterization of the CD55 (DAF)-binding site on the seven-span transmembrane receptor CD97. Eur. J. Immunol. 28 (1998) 1701-1707
40. Hamann J., Vogel B., van Schijndel G.M., and van Lier R.A. The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J. Exp. Med. 184 (1996) 1185-1189
41. Lin H.H., et al. Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. J. Biol. Chem. 276 (2001) 24160-24169
42. Kwakkenbos M.J., Pouwels W., Matmati M., Stacey M., Lin H.H., Gordon S., van Lier R.A., and Hamann J. Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells. J. Leukoc. Biol. 77 (2005) 112-119
43. Stacey M., Chang G.W., Davies J.Q., Kwakkenbos M.J., Sanderson R.D., Hamann J., Gordon S., and Lin H.H. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Blood 102 (2003) 2916-2924
44. Lin H.H., Stacey M., Chang G.W., Davies J.Q., and Gordon S. Method for selecting and enriching cells expressing low affinity ligands for cell surface receptors. Biotechniques 38 (2005) 696-698
45. Akiva P., Toporik A., Edelheit S., Peretz Y., Diber A., Shemesh R., Novik A., and Sorek R. Transcription-mediated gene fusion in the human genome. Genome Res. 16 (2006) 30-36
46. Parra G., Reymond A., Dabbouseh N., Dermitzakis E.T., Castelo R., Thomson T.M., Antonarakis S.E., and Guigo R. Tandem chimerism as a means to increase protein complexity in the human genome. Genome Res. 16 (2006) 37-44
47. Caudevilla C., et al. Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing. Nucleic Acids Res. 29 (2001) 3108-3115
48. Tanaka K., Watakabe A., and Shimura Y. Polypurine sequences within a downstream exon function as a splicing enhancer. Mol. Cell Biol. 14 (1994) 1347-1354
49. Takahara T., Tasic B., Maniatis T., Akanuma H., and Yanagisawa S. Delay in synthesis of the 3′ splice site promotes trans-splicing of the preceding 5′ splice site. Mol. Cell 18 (2005) 245-251
50. Hamann J., et al. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. Eur. J. Immunol. 37 (2007) 2797-2802