Expression of angiopoietin-1 in human glioblastomas regulates tumor-induced angiogenesis in vivo and in vitro studies

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 4, 2001, Pages 536-541

  Audero, Enrica ^a,b   Cascone, Ilaria ^a,b   Zanon, Ilaria ^a,b   Previtali, Stefano C ^c   Piva, Roberto ^b   Schiffer, Davide ^b   Bussolino, Federico ^a,b  

^a CANDIOLO CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Angiogenesis; Angiopoietins; Glioblastomas

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; MESSENGER RNA; TYROSINE KINASE RECEPTOR; TYROSINE KINASE RECEPTOR TIE2; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; ASTROCYTOMA; BLOOD VESSEL; CANCER GRADING; CELL INTERACTION; CELL SPREADING; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; TUMOR GROWTH;

EID: 0035046058     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.4.536     Document Type: Article

References (29)

1. Patient age, histological features and length of survival in patients with glioblastoma multiforme
2. Molecular mechanisms of blood vessel formation
3. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas
4. Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanism
5. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
6. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
7. tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
8. Expression of endothelial-specific receptors tyrosine kinases and growth factors in human brain tumors
9. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
10. Direct actions of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors
11. Angiopoietin-1 induces sprouting angiogenesis in vitro
12. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
13. Requisite role of angiopoietin-1, a ligand for the Tie2 receptor, during embryonic angiogenesis
14. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
15. In situ hybridization analysis of Girk2 expression in the developing central nervous system in normal and weaver mice
16. Baculoviruses as gene expression vectors
17. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
18. Endothelial adhesion molecules in the development of the vascular tree: The garden of forking paths
19. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
20. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
21. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor
22. Increased vascularization in mice overexpressing angiopoietin-1
23. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
24. In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis
25. Catalyzed reporter deposition, a novel method of signal amplification: Application to immunoassays
26. A novel in situ hybridization signal amplification method, based on the deposition of biotinylated tyramide
27. Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2
28. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis