Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor

Peptides

Volumn 29, Issue 3, 2008, Pages 412-418

  Yamada, Yuko ^a   Yamauchi, Daiki ^a   Usui, Hachiro ^a   Zhao, Hui ^a   Yokoo, Megumi ^a   Ohinata, Kousaku ^a   Iwai, Masaru ^b   Horiuchi, Masatsugu ^b   Yoshikawa, Masaaki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin; AT2 receptor; Blood pressure; IP receptor; Nitric oxide; Novokinin; Ovokinin(2 7); Prostacyclin; Spontaneously hypertensive rat

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANTIHYPERTENSIVE AGENT; CAY 10441; INDOMETACIN; NOVOKININ; OVALBUMIN; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SYSTOLIC BLOOD PRESSURE;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; EGG PROTEINS; IMIDAZOLES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PYRIDINES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, PROSTAGLANDIN;

MUS; RATTUS;

EID: 39649101950     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2007.11.017     Document Type: Article

References (22)

1. Baranov D., and Armstead W.M. Nitric oxide contributes to AT2 but not AT1 angiotensin II receptor-mediated vasodilatation of porcine pial arteries and arterioles. Eur J Pharmacol 525 (2005) 112-116
2. Batenburg W.W., Garrelds I.M., Bernasconi C.C., Juillerat-Jeanneret L., van Kats J.P., Saxena P.R., et al. Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. Circulation 109 (2004) 2296-2301
3. Fujita H., Yokoyama K., and Yoshikawa M. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J Food Sci 65 (2000) 564-569
4. Fukada S.Y., Tirapelli C.R., de Godoy M.A., and de Oliveira A.M. Mechanisms underlying the endothelium-independent relaxation induced by angiotensin II in rat aorta. J Cardiovasc Pharmacol 45 (2005) 136-143
5. Guthrie Jr. G.P. Angiotensin receptors: physiology and pharmacology. Clin Cardiol 18 (1995) 29-34
6. Hein L., Barsh G.S., Pratt R.E., Dzau V., and Kobilka B.K. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 377 (1995) 744-747
7. Ichiki T., Labosky P.A., Shiota C., Okuyama S., Imagawa Y., Fogo A., et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377 (1995) 748-750
8. Matoba N., Usui H., Fujita H., and Yoshikawa M. A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett 452 (1999) 181-184
9. Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., and Dzau V.J. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem 268 (1993) 24539-24542
10. Naveri L., Stromberg C., and Saavedra J.M. Angiotensin II AT1 receptor mediated contraction of the perfused rat cerebral artery. Neuroreport 5 (1994) 2278-2280
11. Pihlanto-Leppala A., Rokka T., and Korhonen H. Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int Dairy J 8 (1998) 325-331
12. Sasaki K., Yamano Y., Bardhan S., Iwai N., Murray J.J., Hasegawa M., et al. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature 351 (1991) 230-233
13. Savoia C., Ebrahimian T., He Y., Gratton J.P., Schiffrin E.L., and Touyz R.M. Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. J Hypertens 24 (2006) 2417-2422
14. Scruggs P., Filipeanu C.M., Yang J., Chang J.K., and Dun N.J. Interaction of ovokinin(2-7) with vascular bradykinin 2 receptors. Regul Pept 120 (2004) 85-91
15. Sugaya T., Nishimatsu S., Tanimoto K., Takimoto E., Yamagishi T., Imamura K., et al. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem 270 (1995) 18719-18722
16. Tamura M., Takagi T., Howard E.F., Landon E.J., Steimle A., Tanner M., et al. Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J Hypertens 18 (2000) 1239-1246
17. Tsutsumi Y., Matsubara H., Masaki H., Kurihara H., Murasawa S., Takai S., et al. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest 104 (1999) 925-935
18. Wan Y., Wallinder C., Plouffe B., Beaudry H., Mahalingam A.K., Wu X., et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 47 (2004) 5995-6008
19. Webb M.L., Monshizadegan H., Dickinson K.E., Serafino R., Moreland Sm Michel I., Seiler S.M., et al. Binding and signal transduction of the cloned vasocular angiotensin II (AT1a) receptor cDNA stably expressed in Chinese hamster over cells. Regul Pept 44 (1993) 131-139
20. Whitebread S.E., Taylor V., Bottari S.P., Kamber B., and de Gasparo M. Radioiodinated CGP 42112A: a novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors. Biochem Biophys Res Commun 181 (1991) 1365-1371
21. Yamada Y., Matoba N., Usui H., Ohnishi K., and Yoshikawa M. Design of a highly potent anti-hypertensive peptide based on ovokinin(2-7). Biosci Biotechnol Biochem 66 (2002) 1213-1217
22. 2-and IP-receptor-mediated mechanism in the mesenteric artery from SHRs. Biosci Biotechnol Biochem, in press.