Cutaneous perspectives on adaptive immunity

Clinical Reviews in Allergy and Immunology

Volumn 33, Issue 1-2, 2007, Pages 4-14

  Girardi, Michael ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptive immunity; Cutaneous inflammation; Skin homing; T cell subsets; T regulatory cells; TH1 and TH2 cytokines; TH17

Indexed keywords

CHEMOKINE; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR; TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CLONAL ANERGY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATITIS; ENDOTHELIUM CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE HOMING; REGULATORY T LYMPHOCYTE; REVIEW; SKIN; SKIN INFLAMMATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; CELL DIFFERENTIATION; IMMUNITY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PHYSIOLOGY;

ANIMALS; ANTIGEN PRESENTATION; B-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; HUMANS; IMMUNE TOLERANCE; IMMUNITY; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; SKIN; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS;

EID: 39649096115     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12016-007-0040-9     Document Type: Review

References (39)

1. Robert C, Kupper TS (1999) Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med 341(24):1817-1828
2. Vishwanath M, Nishibu A, Saeland S et al (2006) Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover. J Invest Dermatol 126:2452-2457
3. Nishibu A, Ward BR, Jester JV et al (2006) Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol 126:787-796
4. Stingl G, Gazze-Stingl LA, Aberer W, Wolff K (1981) Antigen presentation by murine epidermal Langerhans cells and its alteration by ultraviolet B light. J Immunol 127(4):1707-1713
5. Bennett CL, van Rijn E, Jung S, Inaba K, Steinman RM, Kapsenberg ML, Clausen BE (2005) Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169:569-576
6. Kaplan DH, Jenison MC, Saeland S et al (2005) Immunity 23:611-620
7. Larrengina AT, Falo LD (2005) Changing paradigms in cutaneous immunology: adapting with dendritic cells. J Invest Dermatol 124(1):1-12
8. Heath WR, Carbone FR (2003) Dangerous liaisons. Nature 425:460-461
9. Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-995
10. Kupper TS (2000) T cells, immunosurveillance, and cutaneous immunity. J Dermatol Sci 24:S41-S45
11. + T cells are resident in normal skin. J Immunol 176:4431-4439
12. Janeway CA, Travers P, Walport M, Shlomchik M (eds) (2005) Immunobiology: the immune system in health and disease, 6th edn. Garland, New York, USA
13. Girardi M (2006) Immunosurveillance and immunoregulation by γδ T cells. J Invest Dermatol 126:25-31
14. Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM et al (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68(5):855-867
15. Sad S, Marcotte R, Mosmann TR (1995) Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity 2(3):271-279
16. Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL (2006) TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol 177(1):298-305
17. Modlin RL (1994) Th1-Th2 paradigm: insights from leprosy. J Invest Dermatol 102(6):828-832
18. Saed G, Fivenson DP, Naidu Y, Nickoloff BJ (1994) Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile. J Invest Dermatol 103(1):29-33
19. Biedermann T, Rocken M, Carballido JM (2004) TH1 and TH2 lymphocyte development and regulation of TH cell-mediated immune responses of the skin. J Investig Dermatol Symp Proc 9(1):5-14
20. Ohmen JD, Hanifin JM, Nickoloff BJ, Rea TH, Wyzykowski R, Kim J, Jullien D, McHugh T, Nassif AS, Chan SC et al (1995) Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions. J Immunol 154(4):1956-1963
21. Cookson WO et al (2001) Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat Genet 27:372-373
22. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP et al (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38(4):441-446
23. Herrick CA, Xu L, McKenzie ANJ et al (2003) IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J Immunol 170:2488-2495
24. Herrick CA, MacLeod H, Glusac E, et al (2000) Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J Clin Invest 105:765-775
25. Stockinger B, Veldhoen M (2007) Differentiation and function of Th17 T cells. Current Opinion in Immunology 19:281-286
26. Beissert S, Schwarz A, Schwarz T (2006) Regulatory T cells. J Invest Dermatol 126(1):15-24
27. Lu L-F, Lind EF, Gondek DC et al (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442:997-1002
28. + Tregs and NKT cells: regulators regulating regulators. Trends Immunol 27:320-327
29. Veldman CM, Gebhard KL, Uter W, Wassmuth R, Grotzinger J, Schultz E, Hertl M (2004) T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals. J Immunol 172(6):3883-3892
30. Leung DY, Travers JB, Giorno R, Norris DA, Skinner R, Aelion J, Kazemi LV, Kim MH, Trumble AE, Kotb M et al (1995) Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis. J Clin Invest 96(5):2106-2112
31. Strange P, Skov L, Lisby S, Nielsen PL, Baadsgaard O (1996) Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 132(1):27-33
32. Skov L, Baadsgaard O (2000) Bacterial superantigens and inflammatory skin diseases. Clin Exp Dermatol 25(1):57-61
33. Ackerman AL, Cresswell P (2004) Cellular mechanisms governing cross-presentation of exogenous antigens. Nat Immunol 5:678-684
34. Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL (2004) Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest 113(5):701-708
35. Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE, Hayday AC (2005) The integration of conventional and unconventional T cells that characterizes cell-mediated responses. Adv Immunol 87:27-59
36. Girardi M, Oppenheim DE, Steele CR, Lewis JM, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar RE, Hayday AC (2001) Regulation of cutaneous malignancy by γδ T cells. Science 294(5542):605-609
37. Moris A, Rothenfusser S, Meuer E, Hangretinger R, Fisch P (1999) Role of γδ T cells in tumor immunity and their control by NK receptors. Microbes Infect 1(3):227-234
38. Holtmeier W, Kabelitz D (2005) γδ T cells link innate and adaptive immune responses. Chem Immunol Allergy 86:151-183
39. Bonneville M, Fournie JJ (2005) Sensing cell stress and transformation through Vγ9Vδ2 T cell-mediated recognition of the isoprenoid pathway metabolites. Microbes Infect 7(3):503-509