Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover

Journal of Investigative Dermatology

Volumn 126, Issue 11, 2006, Pages 2452-2457

  Vishwanath, Mridula ^a   Nishibu, Akiko ^a   Saeland, Sem ^b   Ward, Brant R ^a   Mizumoto, Norikatsu ^a   Ploegh, Hidde L ^c   Boes, Marianne ^d   Takashima, Akira ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL SUBPOPULATION; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPIDERMIS CELL; HALF LIFE TIME; HUMAN; HUMAN CELL; IMAGING SYSTEM; IMMUNOBIOLOGY; INTRAVITAL INTERMITTENT CONFOCAL IMAGING SYSTEM; LANGERHANS CELL; MOUSE; NONHUMAN; OBSERVATIONAL METHOD; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; EPIDERMIS; GREEN FLUORESCENT PROTEINS; LANGERHANS CELLS; MICE; MICE, MUTANT STRAINS; MICROSCOPY, CONFOCAL;

EID: 33750063997     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700448     Document Type: Article

References (30)

1. + dendritic cells but not by Langerhans cells. Science 301:1925-8
2. Bennett CL, van Rijn E, Jung S, Inaba K, Steinman RM, Kapsenberg ML et al. (2005) Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 169:569-76
3. Boes M, Cerny J, Massol R, Op dB, Kirchhausen T, Chen J et al. (2002) T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418:983-8
4. Borkowski TA, Letterio JJ, Farr AG, Udey MC (1996) A role for endogenous transforming growth factor β1 in Langerhans cell biology: the skin of transforming growth factor β1 null mice is devoid of epidermal Langerhans cells. J Exp Med 184:2417-22
5. Choi KL, Sauder DN (1987) Epidermal Langerhans cell-density and contact sensitivity in young and aged Balb/C mice. Mech Ageing Dev 39:69-79
6. Douillard P, Stoitzner P, Tripp C, Clair-Moninot V, Aït-Yahia S, McLellan A et al. (2005) Mouse lymphoid tissue contains distinct subsets of langerin/CD 207+ dendritic cells, only one of which represents epidermalderived Langerhans cells. J Invest Dermatol 12:983-94
7. Elbe A, Tschachler E, Steiner G, Binder A, Wolff K, Stingl G (1989) Maturational steps of bone marrow-derived dendritic murine epidermal cells. J Immunol 143:2431-8
8. Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM et al. (2006) Langerhans cells arise from monocytes in vivo. Nat Immunol 7:265-73
9. Hemmi H, Yoshino M, Yamazaki H, Naito M, Iyoda T, Omatsu Y et al. (2001) Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-β1-dependent cells. Int Immunol 13:695-704
10. Hoetzenecker W, Meingassner JG, Ecker R, Stingl G, Stuetz A, Elbe-Burger A (2004) Corticosteroids but not pimecrolimus affect viability, maturation and immune function of murine epidermal Langerhans cells. J Invest Dermatol 122:673-84
11. Holzmann S, Tripp CH, Schmuth M, Janke K, Koch F, Saeland S et al. (2004) A model system using tape stripping for characterization of Langerhans cell-precursors in vivo. J Invest Dermatol 122:1165-74
12. + T cells by exogenous cell-associated antigens. Immunity 17:211-20
13. Kamath AT, Henri S, Battye F, Tough DF, Shortman K (2002) Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood 100:1734-41
14. Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ (2005) Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23:611-20
15. Katz SI, Tamaki K, Sachs DH (1979) Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature 282:324-6
16. Kissenpfennig A, Henri S, Dubois B, Laplace-Builhe C, Perrin P, Romani N et al. (2005) Dynamics and function of Langerhans cells in vivo dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643-54
17. Larregina AT, Falo LD (2005) Changing paradigms in cutaneous immunology: adapting with dendritic cells. J Invest Dermatol 124:1-12
18. + cells differentiate into Langerhans cells. Nat Immunol 2:1151-8
19. Lutz MB, Schuler G (2002) Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 23:445-9
20. Merad M, Hoffmann P, Ranheim E, Slaymaker S, Manz MG, Lira SA et al. (2004) Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med 10:510-7
21. Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I et al. (2002) Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3:1135-41
22. Nishibu A, Ward BR, Jester JV, Ploegh HL, Boes M, Takashima A (2006) Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. J Invest Dermatol 126:787-96
23. Ritter U, Meissner A, Scheidig C, Korner H (2004) CD8α- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis. Eur J Immunol 34:1542-50
24. Romani N, Holzmann S, Tripp CH, Koch F, Stoitzner P (2003) Langerhans cells - dendritic cells of the epidermis. Apmis 111:725-40
25. Ruedl C, Koebel P, Bachmann M, Hess M, Karjalainen K (2000) Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J Immunol 165:4910-6
26. Steinman RM, Nussenzweig MC (2002) Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 99:351-8
27. Stoitzner P, Holzmann S, McLellan AD, Ivarsson L, Stossel H, Kapp M et al. (2003) Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. J Invest Dermatol 120:266-74
28. Stoitzner P, Tripp CH, Douillard P, Saeland S, Romani N (2005) Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation. J Invest Dermatol 125:116-25
29. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12:71-81
30. Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, Zhu J et al. (2003) Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med 197:153-62