Fulminant central nervous system demyelination associated with interferon-α therapy and hepatitis C virus infection

Multiple Sclerosis

Volumn 13, Issue 9, 2007, Pages 1100-1106

  Hoftberger R ^a   Garzuly, F ^b   Dienes, H P ^c   Grubits, J ^d   Rohonyi, B ^d   Fischer, G ^e   Hanzely, Z ^f   Lassmann, H ^e   Budka, Herbert ^a,e  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Markusovszky Teaching Hospital   (Hungary)

^c UNIVERSITY OF COLOGNE   (Germany)

^d Elisabeth Teaching Hospital   (Hungary)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f NATIONAL INSTITUTE OF NEUROSURGERY   (Hungary)

Author keywords

CD8+ T cells; Concentric sclerosis (Bal ); Hepatitis C virus; Interferon ; Multiple sclerosis (MS)

Indexed keywords

ALPHA INTERFERON; COMPLEMENT COMPONENT C3; IMMUNOGLOBULIN M; METHYLPREDNISOLONE; VIRUS RNA; ANTIVIRUS AGENT;

ADULT; ARTICLE; AUTOPSY; BRAIN BIOPSY; CASE REPORT; CHRONIC HEPATITIS; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DEATH; DELIRIUM; DEMYELINATING DISEASE; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; GAIT DISORDER; HEMIPARESIS; HEPATITIS C; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOALGESIA; IMAGE ANALYSIS; IMMUNOPATHOGENESIS; LEUKOCYTOCLASTIC VASCULITIS; LEUKOPENIA; LIVER CIRRHOSIS; MULTIPLE SCLEROSIS; PELIZAEUS MERZBACHER DISEASE; PLEOCYTOSIS; PROTEIN LOCALIZATION; PSYCHOSIS; SEIZURE; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; T LYMPHOCYTE; THORACIC SPINAL CORD; URINE INCONTINENCE; ACUTE DISEASE; BIOPSY; CHEMICALLY INDUCED DISORDER; GENETICS; HEPATITIS C VIRUS; HOSPITALIZATION; ISOLATION AND PURIFICATION; PATHOLOGY;

ACUTE DISEASE; ADULT; ANTIVIRAL AGENTS; BIOPSY; DEMYELINATING DISEASES; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; RNA, VIRAL; SEVERITY OF ILLNESS INDEX;

EID: 39549097398     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458507078684     Document Type: Article

References (44)

1. Forton DM, Karayiannis P, Mahmud N, Taylor-Robinson SD, Thomas HC. Identification of unique hepatitis C virus quasispecies in the central nervous system and comparative analysis of internal translational efficiency of brain, liver, and serum variants. J Virol 2004; 78: 5170-83.
2. Radkowski M, Wilkinson J, Nowicki M, Adair D, Vargas H, Ingui C et al. Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. J Virol 2002; 76: 600-608.
3. Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J et al. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol 1998; 161: 1947-53.
4. Nissen MH, Larsen JK, Plesner T, Olesen BK, Ernst P. Alpha-interferon induces enhanced expression of HLA-ABC antigens and beta-2-microglobulin in vivo and in vitro in various subsets of human lymphoid cells. Clin Exp Immunol 1987; 69: 632-38.
5. Stadelmann C, Ludwin S, Tabira T, Guseo A, Lucchinetti CF, Leel-Ossy L et al. Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis. Brain 2005; 128: 979-87.
6. Dries V, von Both I, Muller M, Gerken G, Schirmacher P, Odenthal M et al. Detection of hepatitis C virus in paraffin-embedded liver biopsies of patients negative for viral RNA in serum. Hepatology 1999; 29: 223-29.
7. Fries JW, Roth T, Dienes HP, Weber M, Odenthal M. A novel evaluation method for paraffinized human renal biopsies using quantitative analysis of microdissected glomeruli and VCAM-1 as market of inflammatory mesangial cell activation. Nephrol Dial Transplant 2003; 18: 710-16.
8. Aboul-Enein F, Rauschka H, Kornek B, Stadelmann C, Stefferl A, Bruck W et al. Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Exp Neurol 2003; 62: 25-33.
9. Preziati D, La Rosa L, Covini G, Marcelli R, Rescalli S, Persani L et al. Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon alpha-2a. Eur J Endocrinol 1995; 132: 587-93.
10. Kataoka I, Shinagawa K, Shiro Y, Okamoto S, Watanabe R, Mori T et al. Multiple sclerosis associated with interferon-alpha therapy for chronic myelogenous leukemia. Am J Hematol 2002; 70: 149-53.
11. Matsuo T, Takabatake R. Multiple sclerosis-like disease secondary to alpha interferon. Ocul Immunol Inflamm 2002; 10: 299-304.
12. Friese MA, Fugger L. Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain 2005; 128: 1747-63.
13. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707-17.
14. Hayashi T, Morimoto C, Burks JS, Kerr C, Hauser SL. Dual-label immunocytochemistry of the active multiple sclerosis lesion: major histocompatibility complex and activation antigens. Ann Neurol 1988; 24: 523-31.
15. Nyland H, Mork S, Matre R. In-situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis. Neuropathol Appl Neurobiol 1982; 8: 403-11.
16. Booss J, Esiri MM, Tourtellotte WW, Mason DY. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J Neurol Sci 1983; 62: 219-32.
17. Gay FW, Drye TJ, Dick GW, Esiri MM. The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain 1997; 120: 1461-83.
18. Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R et al. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 2000; 192: 393-404.
19. Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120: 393-99.
20. Kornek B, Lassmann H. Axonal pathology in multiple sclerosis. A historical note. Brain Pathol 1999; 9: 651-56.
21. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278-85.
22. Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Bruck W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 2000; 123: 1174-83.
23. Aboul-Enein F, Lassmann H. Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease? Acta Neuropathol (Berl) 2005; 109: 49-55.
24. Laskus T, Radkowski M, Bednarska A, Wilkinson J, Adair D, Nowicki M et al. Detection and analysis of hepatitis C virus sequences in cerebrospinal fluid. J Virol 2002; 76: 10064-68.
25. Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995; 80: 695-705.
26. Julien J, Vital C, Vallat JM, Lagueny A, Deminiere C, Darriet D. Polyneuropathy in Waldenstrom's macroglobulinemia. Deposition of M component on myelin sheaths. Arch Neurol 1978; 35: 423-25.
27. Durelli L, Bongioanni MR, Cavallo R, Ferrero B, Ferri R, Ferrio MF et al. Chronic systemic high-dose recombinant interferon alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis. Neurology 1994; 44: 406-13.
28. Camenga DL, Johnson KP, Alter M, Engelhardt CD, Fishman PS, Greenstein JI et al. Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis. Arch Neurol 1986; 43: 1239-46.
29. Larrey D, Marcellin P, Freneaux E, Pessayre D, Benhamou JP. Exacerbation of multiple sclerosis after the administration of recombinant human interferon alfa. JAMA 1989; 261: 2065.
30. Corcia P, Barbereau D, Guennoc AM, de Toffol B, Bacq Y. Improvement of a CIDP associated with hepatitis C virus infection using antiviral therapy. Neurology 2004; 63: 179-80.
31. Caudai C, Maimone D, Almi P, Annunziata P, Bastianoni I, Boggiano CA et al. The potential role of hepatitis C virus in the pathogenesis of the neurological syndrome in chronic hepatitis C. Gut 1997; 41: 411-12.
32. Heckmann JG, Kayser C, Heuss D, Manger B, Blum HE, Neundorfer B. Neurological manifestations of chronic hepatitis C. J Neurol 1999; 246: 486-91.
33. Authier FJ, Bassez G, Payan C, Guillevin L, Pawlotsky JM, Degos JD et al. Detection of genomic viral RNA in nerve and muscle of patients with HCV neuropathy. Neurology 2003; 60: 808-12.
34. Sobukawa E, Sakimura K, Hoshino S, Hoshino M, Miyoshi K. Hepatic myelopathy: an unusual neurological complication of advanced hepatic disease. Intern Med 1994; 33: 718-22.
35. Zandman-Goddard G, Levy Y, Weiss P, Shoenfeld Y, Langevitz P. Transverse myelitis associated with chronic hepatitis C. Clin Exp Rheumatol 2003; 21: 111-13.
36. Grewal AK, Lopes MB, Berg CL, Bennett AK, Alves VA, Trugman JM. Recurrent demyelinating myelitis associated with hepatitis C viral infection. J Neurol Sci 2004; 224: 101-106.
37. Nolte CH, Endres AS, Meisel H. Sensory ataxia in myelopathy with chronic hepatitis C virus infection. Neurology 2002; 59: 958.
38. Bolay H, Soylemezoglu F, Nurlu G, Tuncer S, Varli K. PCR detected hepatitis C virus genome in the brain of a case with progressive encephalomyelitis with rigidity. Clin Neurol Neurosurg 1996; 98: 305-308.
39. Vargas HE, Laskus T, Radkowski M, Wilkinson J, Balan V, Douglas DD et al. Detection of hepatitis C virus sequences in brain tissue obtained in recurrent hepatitis C after liver transplantation. Liver Transpl 2002; 8: 1014-19.
40. Maggi F, Giorgi M, Fornai C, Morrica A, Vatteroni ML, Pistello M et al. Detection and quasispecies analysis of hepatitis C virus in the cerebrospinal fluid of infected patients. J Neurovirol 1999; 5: 319-23.
41. Sacconi S, Salviati L, Merelli E. Acute disseminated encephalomyelitis associated with hepatitis C virus infection. Arch Neurol 2001; 58: 1679-81.
42. Fujita H, Chuganji Y, Yaginuma M, Momoi M, Tanaka T. Case report: acute encephalitis immediately prior to acute onset of hepatitis C virus infection. J Gastroenterol Hepatol 1999; 14: 1129-31.
43. Anthoney DA, Bone I, Evans TR. Inflammatory demyelinating polyneuropathy: a complication of immunotherapy in malignant melanoma. Ann Oncol 2000; 11: 1197-200.
44. Meriggioli MN, Rowin J. Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha. Muscle Nerve 2000; 23: 433-35.