Effects of IL-15 on rat brown adipose tissue: Uncoupling proteins and PPARs

Obesity

Volumn 16, Issue 2, 2008, Pages 285-289

  Almendro, Vanessa ^a   Fuster, Gemma ^a   Busquets, Sílvia ^a   Ametller, Elisabet ^a   Figueras, Maite ^a   Argilés, Josep M ^a   López Soriano, Francisco J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; INTERLEUKIN 15; ION CHANNEL; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BROWN ADIPOSE TISSUE; LIPID METABOLISM; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RAT; THERMOGENESIS; WISTAR RAT;

ADIPOSE TISSUE, BROWN; ANIMALS; FATTY ACIDS; INTERLEUKIN-15; ION CHANNELS; LIPID METABOLISM; MALE; MITOCHONDRIAL PROTEINS; OXIDATION-REDUCTION; PPAR ALPHA; PPAR DELTA; RATS; RATS, WISTAR; RNA, MESSENGER; THERMOGENESIS;

RATTUS; RATTUS NORVEGICUS;

EID: 39449134021     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.47     Document Type: Article

References (33)

1. Visscher TL, Seidell JC. The public health impact of obesity. Annu Rev Public Health 2001;22:355-375.
2. Popkin BM, Doak CM. The obesity epidemic is a worldwide phenomenon. Nutr Rev 1998;56:106-114.
3. Grimaldi PA. Regulatory role of peroxisome proliferator-activated receptor delta (PPAR delta) in muscle metabolism. A new target for metabolic syndrome treatment? Biochimie 2005;87:5-8.
4. Ferre R The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004;53:S43-S50.
5. Berger JP, Akiyama TE, Meinke PT. PPARs: therapeutic targets for metabolic disease. Trends Pharmacol Sci 2005;26:244-251.
6. Escher R Braissant O, Basu-Modak S et al. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001;142:4195-4202.
7. Barbera MJ, Schluter A, Pedraza N et al. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J Biol Chem 2001;276:1486-1493.
8. Xue B, Coulter A, Rim JS, Koza RA, Kozak LR Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol 2005;25:8311-8322.
9. Bogacka I, Ukropcova B, McNeil M, Gimble JM, Smith SR. Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. J Clin Endocrinol Metab 2005;90:6650-6656.
10. Luquet S, López-Soriano J, Holst D et al. Roles of peroxisome proliferator-activated receptor delta (PPARdelta) in the control of fatty acid catabolism. A new target for the treatment of metabolic syndrome. Biochimie 2004;86:833-837.
11. Wang YX, Lee CH, Tiep S et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003;113:159-170.
12. Luquet S, López-Soriano J, Holst D et al. Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB J 2003;17:2299-2301.
13. Carson WE, Giri JG, Lindemann MJ et al. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 1994;180:1395-1403.
14. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 1995;154:483-500.
15. Akbar AN, Borthwick NJ, Wickremasinghe RG et al. lnterleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol 1996;26:294-299.
16. Girard D, Paquet ME, Paquin R, Beaulieu AD. Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15. Blood 1996;88:3176-3184.
17. Girl JG, Ahdieh M, Eisenman J et al. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 1994;13:2822-2830.
18. Grabstein KH, Eisenman J, Shanebeck K et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994;264:965-968.
19. Carbó N, López-Soriano J, Costelli P et al. Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. Br J Cancer 2000;83:526-531.
20. Carbó N, López-Soriano J, Costelli P et al. Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim Biophys Acta 2001;1526:17-24.
21. Alvarez B, Carbó N, López-Soriano J et al. Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue. Biochim Biophys Acta 2002;1570:33-37.
22. Quinn LS, Strait-Bodey L, Anderson BG, Argilés JM, Havel PJ. Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway. Cell Biol Int 2005;29:449-457.
23. Almendro V, Busquets S, Ametller E et al. Effects of Interleukin-15 on lipid oxidation. Disposal of an oral [14C]-triolein load. Biochim Biophys Acta 2006;1761:37-42.
24. Stansbie D, Brownsey RW, Crettaz M, Denton RM. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J 1976;160:413-416.
25. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
26. Fleury C, Sanchís D. The mitochondrial uncoupling protein-2: current status. Int J Biochem Cell Biol 1999;31:1261-1278.
27. Quinn LS, Anderson BG, Drivdahl RH, Alvarez B, Argiles JM. Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders. Exp Cell Res 2002;280:55-63.
28. Quinn LS, Haugk KL, Grabstein KH. Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 1995;136:3669-3672.
29. López-Soriano J, Carbó N, Almendro V et al. Rat liver lipogenesis is modulated by interleukin-15. Int J Mol Med 2004;13:817-819.
30. Figueras M, Busquets S, Carbó N et al. Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wastring in tumour-bearing rats. FEBS Lett 2004;569:201-206.
31. Nedergaard J, Petrovic N, Lindgren EM, Jacobsson A, Cannon B. PPARgamma in the control of brown adipocyte differentiation. Biochim Biophys Acta 2005;1740:293-304.
32. Tanaka T, Yamamoto J, Iwasaki S et al. Activation of peroxisome prollferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci USA 2003;100:15924-15929.
33. Fyffe SA, Alphey MS, Buetow L et al. Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids. J Mol Biol 2006;356:1005-1013.