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Volumn 26, Issue 4, 2007, Pages 254-259

Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet

Author keywords

Cholesterol; Streptozotocin; Triglycerides; Videocapillaroscopy; VULM 1457

Indexed keywords

1 (2,6 DIISOPROPYLPHENYL) 3 [4 (4' NITROPHENYLTHIO)PHENYL]UREA; ANTILIPEMIC AGENT; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; GLUCOSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VULM 1457;

EID: 39449106412     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (33)
  • 1
    • 0034023061 scopus 로고    scopus 로고
    • Accad M., Smith S. J., Newland D. L., Sanan D. A., King L. E. Jr., Linton M. F., Fazio S., Farese R. V. Jr. (2000): Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA: cholesterol acyltransferase 1. J. Clin. Invest. 105, 711-719
    • Accad M., Smith S. J., Newland D. L., Sanan D. A., King L. E. Jr., Linton M. F., Fazio S., Farese R. V. Jr. (2000): Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA: cholesterol acyltransferase 1. J. Clin. Invest. 105, 711-719
  • 3
    • 0036898999 scopus 로고    scopus 로고
    • Genotoxicity of streptozotocin
    • Bolzan A. D., Bianchi M. (2002): Genotoxicity of streptozotocin. Mutant. Res. 512, 121-134
    • (2002) Mutant. Res , vol.512 , pp. 121-134
    • Bolzan, A.D.1    Bianchi, M.2
  • 4
    • 31044443222 scopus 로고    scopus 로고
    • The ACAT inhibitor avasimibe increases the fractional clearance rate of postprandial triglyceride- rich lipoproteins in miniature pigs
    • Burnett J. R., Telford D. E., Barrett P. R., Huff M. W. (2005): The ACAT inhibitor avasimibe increases the fractional clearance rate of postprandial triglyceride- rich lipoproteins in miniature pigs. Biochim. Biophys. Acta. 1738, 10-18
    • (2005) Biochim. Biophys. Acta , vol.1738 , pp. 10-18
    • Burnett, J.R.1    Telford, D.E.2    Barrett, P.R.3    Huff, M.W.4
  • 8
    • 0036037415 scopus 로고    scopus 로고
    • The effect of cholesterol levels on hemorheological parameters in diabetic patients
    • Ercan M., Konukoglu D., Erdem T., Onen S. (2002): The effect of cholesterol levels on hemorheological parameters in diabetic patients. Clin. Hemorheol. Microcirc. 4, 257-263
    • (2002) Clin. Hemorheol. Microcirc , vol.4 , pp. 257-263
    • Ercan, M.1    Konukoglu, D.2    Erdem, T.3    Onen, S.4
  • 10
    • 33746802495 scopus 로고    scopus 로고
    • The nine lives of ACAT inhibitors
    • Farese R. V. (2005): The nine lives of ACAT inhibitors. Arterioscler. Thromb. Vasc. Biol. 26, 1684-1686
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 1684-1686
    • Farese, R.V.1
  • 11
    • 0034877540 scopus 로고    scopus 로고
    • Computer capillaroscopy as a channel of local visualization, non-invasive diagnostics, and screening of substances in circulating blood. Congress Optical Technologies in Biophysics and Medicine II
    • Gurfinkel Y. I., Valery T. (2001): Computer capillaroscopy as a channel of local visualization, non-invasive diagnostics, and screening of substances in circulating blood. Congress Optical Technologies in Biophysics and Medicine II, Proc. SPIE 4241, 467-472
    • (2001) Proc. SPIE , vol.4241 , pp. 467-472
    • Gurfinkel, Y.I.1    Valery, T.2
  • 14
    • 0033536189 scopus 로고    scopus 로고
    • Insulin resistance and lipid metabolism
    • Howard B. V. (1999): Insulin resistance and lipid metabolism. Am. J. Cardiol. 84, 28-32
    • (1999) Am. J. Cardiol , vol.84 , pp. 28-32
    • Howard, B.V.1
  • 15
    • 0036277246 scopus 로고    scopus 로고
    • Reduce structural and functional skin capillaries in familial combined hyperlipidemia affected men, associated with increased remnant-like lipoprotein cholesterol levels
    • Keulen E. T., Schaper N. C., Houben A. J., van Lin J. M., Lutgens I., Rijkers K., Dallinga-Thie G. M., de Bruin T. W, (2002): Reduce structural and functional skin capillaries in familial combined hyperlipidemia affected men, associated with increased remnant-like lipoprotein cholesterol levels. Atherosclerosis 2, 355-362
    • (2002) Atherosclerosis , vol.2 , pp. 355-362
    • Keulen, E.T.1    Schaper, N.C.2    Houben, A.J.3    van Lin, J.M.4    Lutgens, I.5    Rijkers, K.6    Dallinga-Thie, G.M.7    de Bruin, T.W.8
  • 16
    • 13844271997 scopus 로고    scopus 로고
    • Systemic acyl-CoA:cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia
    • Kharbanda R. K., Wallace S., Walton B., Donald A., Cross J. M., Deanfield J. (2005): Systemic acyl-CoA:cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia. Circulation 111, 804-807
    • (2005) Circulation , vol.111 , pp. 804-807
    • Kharbanda, R.K.1    Wallace, S.2    Walton, B.3    Donald, A.4    Cross, J.M.5    Deanfield, J.6
  • 17
    • 0034128831 scopus 로고    scopus 로고
    • Relationship of dietary fat to glucose metabolism
    • Lichtenstein A. H., Schwab U S. (2000): Relationship of dietary fat to glucose metabolism. Atherosclerosis 150, 227-243
    • (2000) Atherosclerosis , vol.150 , pp. 227-243
    • Lichtenstein, A.H.1    Schwab, U.S.2
  • 20
    • 0023636708 scopus 로고
    • The hyperlipidemic hamster as a model of experimental atherosclerosis
    • Nistor A., Bulla A., Filip D. A., Radu A. (1987): The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis 68, 479-487
    • (1987) Atherosclerosis , vol.68 , pp. 479-487
    • Nistor, A.1    Bulla, A.2    Filip, D.A.3    Radu, A.4
  • 21
    • 39449085361 scopus 로고    scopus 로고
    • Oremus O, Šmahovský V, Fáberová V, Kakalík I, Schmidtová L, Zemánek M, 2002, 1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof. Patent document, Industrial Property Office, Slovak Republic, 282727 B6 in Slovak
    • Oremus O., Šmahovský V., Fáberová V., Kakalík I., Schmidtová L'., Zemánek M. (2002): 1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof. Patent document, Industrial Property Office, Slovak Republic, 282727 B6 (in Slovak)
  • 22
    • 0031426767 scopus 로고    scopus 로고
    • Effect of cholesterol content in diet on capillary flow of rat erythrocytes. Part II: Mechanical properties
    • Peddada R. R., Abugo O. O., Kelly J. F., Roth G. S., Rifkind J. M. (1997): Effect of cholesterol content in diet on capillary flow of rat erythrocytes. Part II: Mechanical properties. Clin. Hemorheol. Microcirc. 17, 445-457
    • (1997) Clin. Hemorheol. Microcirc , vol.17 , pp. 445-457
    • Peddada, R.R.1    Abugo, O.O.2    Kelly, J.F.3    Roth, G.S.4    Rifkind, J.M.5
  • 23
    • 7044235261 scopus 로고    scopus 로고
    • ACAT 2 deficiency limits cholesterol absorption in cholesterol-fed mice: Impact on hepatic cholesterol homeostasis
    • Repa J. J., Buhman K. K., Farese R. V. Jr., Dietschy J. M., Turley S. D. (2004): ACAT 2 deficiency limits cholesterol absorption in cholesterol-fed mice: Impact on hepatic cholesterol homeostasis. Hepatology 40, 108-1097
    • (2004) Hepatology , vol.40 , pp. 108-1097
    • Repa, J.J.1    Buhman, K.K.2    Farese Jr., R.V.3    Dietschy, J.M.4    Turley, S.D.5
  • 24
    • 0034537828 scopus 로고    scopus 로고
    • Cholesterol esters and atherosclerosis - a game of ACAT and mouse
    • Rudel L. L., Shelness G. S. (2000): Cholesterol esters and atherosclerosis - a game of ACAT and mouse. Nat. Med. 12, 1313-1314
    • (2000) Nat. Med , vol.12 , pp. 1313-1314
    • Rudel, L.L.1    Shelness, G.S.2
  • 25
    • 0033510008 scopus 로고    scopus 로고
    • Sotníková R., Nosál'ová V., Štefek M., Štolc S., Gajdošík A., Gajdošíková A. (1999): Streptozotocin diabetes- induced changes in aorta, peripheral nerves and stomach of Wistar rats. Gen. Physiol. Biophys. 18, (Focus Issue) 155-162
    • Sotníková R., Nosál'ová V., Štefek M., Štolc S., Gajdošík A., Gajdošíková A. (1999): Streptozotocin diabetes- induced changes in aorta, peripheral nerves and stomach of Wistar rats. Gen. Physiol. Biophys. 18, (Focus Issue) 155-162
  • 27
    • 33751328494 scopus 로고    scopus 로고
    • Glyco-oxidative mechanisms in glucose toxicity: Biochemical changes of matrix collagen in diabetic rats
    • in Slovak
    • Štefek M., Gajdošíková A., Gajdošík A., Kysel'ová Z., Djoubissie J.-M., Križanová O. (2005): Glyco-oxidative mechanisms in glucose toxicity: biochemical changes of matrix collagen in diabetic rats. Biologia (Bratislava) 60 (Suppl. 17), 109-112 (in Slovak)
    • (2005) Biologia (Bratislava) , vol.60 , Issue.SUPPL. 17 , pp. 109-112
    • Štefek, M.1    Gajdošíková, A.2    Gajdošík, A.3    Kysel'ová, Z.4    Djoubissie, J.-M.5    Križanová, O.6
  • 29
    • 0011029055 scopus 로고    scopus 로고
    • Histological analysis of mouse aorta after overload with cholesterol and γ-radiation
    • in Slovak
    • Ťažká D., Valentová J., Kyselovič J., Seginko J., Švec P. (2000): Histological analysis of mouse aorta after overload with cholesterol and γ-radiation. Biologia (Bratislava) 55, 119-124 (in Slovak)
    • (2000) Biologia (Bratislava) , vol.55 , pp. 119-124
    • Ťažká, D.1    Valentová, J.2    Kyselovič, J.3    Seginko, J.4    Švec, P.5
  • 30
    • 39449096126 scopus 로고    scopus 로고
    • Effect of acat inhibitor on structural changes of rabbit iliacofemoral artery
    • Institute of Molecular Physology and Genetics, Slovak Academy of Sciences, Bratislava in Slovak
    • Ťažká D., Sadloňová I., Štvrtina S., Kochan J., Juranová D., Seginko J., Švec P. (2002): Effect of acat inhibitor on structural changes of rabbit iliacofemoral artery. New Frontiers in Basic Cardiovascular Research. Page 54, Institute of Molecular Physology and Genetics, Slovak Academy of Sciences, Bratislava (in Slovak)
    • (2002) New Frontiers in Basic Cardiovascular Research , pp. 54
    • Ťažká, D.1    Sadloňová, I.2    Štvrtina, S.3    Kochan, J.4    Juranová, D.5    Seginko, J.6    Švec, P.7
  • 31
    • 27244459575 scopus 로고    scopus 로고
    • 3-D nano-mechanics of an erythrocyte junctional complex in equibiaxial and anisotropic deformations
    • Vera C., Skelton R., Bossens F., Sung L. (2005): 3-D nano-mechanics of an erythrocyte junctional complex in equibiaxial and anisotropic deformations. Ann. Biomed. Eng. 33, 1387-1404
    • (2005) Ann. Biomed. Eng , vol.33 , pp. 1387-1404
    • Vera, C.1    Skelton, R.2    Bossens, F.3    Sung, L.4
  • 32
    • 33846379203 scopus 로고    scopus 로고
    • Effect of short term administration of ACAT inhibitor VULM 1457 on selected biochemical parameters and aorta of 5 day diabetic rats fed cholesterol-lipid diet
    • in Slovak
    • Vojtaššáková E., Ťažká D., Adameová A., Matyás Š., Kužel'ová M., Fáberová V., Švec P. (2006): Effect of short term administration of ACAT inhibitor VULM 1457 on selected biochemical parameters and aorta of 5 day diabetic rats fed cholesterol-lipid diet. Farm. Obz. 75, 303-308 (in Slovak)
    • (2006) Farm. Obz , vol.75 , pp. 303-308
    • Vojtaššáková, E.1    Ťažká, D.2    Adameová, A.3    Matyás, S.4    Kužel'ová, M.5    Fáberová, V.6    Švec, P.7
  • 33
    • 0034304285 scopus 로고    scopus 로고
    • Aortic atheromatous lesions developed in APA hamsters with streptozotocin induced diabetes: A new animal model for diabetic atherosclerosis. 1. Histopathological studies
    • Yamanouchi J., Nishida E., Itagaki S., Kawamura S., Doi K., Yoshikawa Y. (2000): Aortic atheromatous lesions developed in APA hamsters with streptozotocin induced diabetes: a new animal model for diabetic atherosclerosis. 1. Histopathological studies Exp. Anim. 49, 259-266
    • (2000) Exp. Anim , vol.49 , pp. 259-266
    • Yamanouchi, J.1    Nishida, E.2    Itagaki, S.3    Kawamura, S.4    Doi, K.5    Yoshikawa, Y.6


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