Systemic acyl-CoA:Cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia

Circulation

Volumn 111, Issue 6, 2005, Pages 804-807

  Kharbanda, Rajesh K ^a   Wallace, Sharon ^a   Walton, Benjamin ^a   Donald, Ann ^a   Cross, Jennifer M ^a   Deanfield, John ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Endothelium; Hypercholesterolemia; Inflammation

Indexed keywords

ACETYLCHOLINE; AVASIMIBE; BRADYKININ; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; GLYCERYL TRINITRATE; LIPID; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; VERAPAMIL;

ACETYLATION; ADULT; ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RESPONSE; ENDOTHELIUM LESION; ENZYME INHIBITION; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; INFLAMMATION; LIPID BLOOD LEVEL; LIPID METABOLISM; MACROPHAGE; MALE; MONOCYTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE BLOOD VESSEL; UNITED KINGDOM; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

ACYL COENZYME A; ADULT; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; INFLAMMATION; LIPIDS; MALE; MIDDLE AGED; PLETHYSMOGRAPHY; STEROL O-ACYLTRANSFERASE; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR RESISTANCE; VASODILATION;

EID: 13844271997     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000155236.25081.9B     Document Type: Article

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