Liver damage in brown trout, Salmo trutta L., and rainbow trout, Oncorhynchus mykiss (Walbaum), following administration of the cyanobacterial hepatotoxin microcystin-LR via the dorsal aorta

Journal of Fish Diseases

Volumn 20, Issue 3, 1997, Pages 209-215

  Bury, N R ^a   McGeer, J C ^a   Eddy, F B ^b   Codd, G A ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOBACTERIA; MYKISS; ONCORHYNCHUS MYKISS; SALMO TRUTTA; SALMONIDAE;

EID: 0030955931     PISSN: 01407775     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2761.1997.00292.x     Document Type: Article

References (33)

1. Addison R.F. (1982) Organochlorine compounds and marine lipids Progressive Lipid Research 21, 47.
2. Alabaster J.S. & Lloyd R. (1982) Water Quality Criteria for Freshwater Fish, 2nd edn. Butterworth, London.
3. Andersen R.J., Luu H.A., Chen D.Z.X., Holmes C.F.B., Kent M.L., Le Blanc M., Taylor F.J.R. & Williams D.E. (1993) Chemical and biological evidence links microcystins to salmon 'net-pen liver disease'. Toxicon 31, 1315-1323.
4. Brooks W.P. & Codd G.A. (1987) Distribution of Microcystis aeruginosa peptide toxin and interactions with hepatic microsomes in mice. Pharmacological Toxicology 60, 187-191.
5. Bury N.R., Eddy F.B. & Codd G.A. (1995) The effects of the cyanobacterium Microcystis aeruginosa, the cyanobacterial hepatotoxin microcystin-LR and ammonia on growth rate and ionic regulation of brown trout (Salmo trutta). Journal of Fish Biology 46, 1042-1055.
6. Casillas E., Sundquist J. & Ames W.E. (1982) Optimization of assay conditions for, and the selected distribution of alanine aminotransferase and aspartate aminotransferase of English sole Parophrys vetulus. Journal of Fish Biology 21, 197-204.
7. Cohen P. (1989) The structure and regulation of protein phosphatases. Annual Reviews in Biochemistry 58, 453-508.
8. Dabholkar A.S. & Carmichael W.W. (1987) Ultrastructural changes in the mouse liver induced by hepatotoxin from the freshwater cyanobacterium Microcystis aeruginosa strain 7820. Toxicon 25, 285-292.
9. Dahlem A.M., Hassan A.S., Swanson S.P., Carmichael W.W. & Beasley V.R. (1989) A model system for studying the bioavailabiliry of intestinally administered microcystin-LR, a hepatotoxic peptide from the cyanobacterium Microcystis aeruginosa, Pharmacological Toxicology 64, 177-181.
10. Davis P.E., Cook L.S.J. & Goenarso D. (1994) Sublethal responses to pesticides of several species of Australian freshwater fish and crustaceans and rainbow trout. Environmental Toxicology and Chemistry 13, 1341-1354.
11. Eriksson J.E., Toivola D., Meriluoto J.A.O., Karaki H., Tan Y.-G. & Hartshorne D. (1990) Hepatocyte deformation induced by cyanobacterial toxins reflect inhibition of protein phosphatases. Biochemical and Biophysical Research Communications 173, 1347-1353.
12. Eriksson J.E., Meriluoto J.A.O. & Lindholm T. (1986) Can cyanobacterial peptide toxins accumulate in aquatic food chains? In: Proceedings of the Fourth International Symposium on Microbial Ecology (ed. by F. Megusar & M. Gantar), pp. 655-658. Slovene Society for Microbiology, Ljubljana
13. Falconer I.R., Jackson A.R.B., Langley J.V. & Runnegar M.T.C. (1981) Liver pathology in mice in poisoning by the blue-green alga Microcystis aeruginosa. Australian Journal of Biological Sciences 34, 179-187.
14. Falconer I.R., Smith J.V., Jackson A.R.B., Jones A. & Runnegar M.T.C. (1988) Oral toxicity of a bloom of the cyanobacterium Microcystis aeruginosa administered to mice over periods up to 1 year. Journal of Toxicology and Environmental Health 24, 291-305.
15. Handy R.D. & Penrice W.S. (1993) The influence of high oral doses of mercuric chloride on organ toxicant concentration and histopathology in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology 106C, 717-724.
16. Hooser S.B., Beasley V.R., Basgall E.J., Carmichael W W. & Haschek W.M. (1990) Microcystin-LR-induced ultrastructural changes in rats. Veterinary Pathology 27, 9-15.
17. Jackson A.R.B., Runnegar M.T.C., Cumming R.B. & Brunner J.F. (1986) Experimental acute toxicarion of young layer and broiler chickens with the cyanobacterium (blue-green alga) Microcystis aeruginosa Avian Pathology 15, 741-748.
18. Lock R.A.C., Balm P.H.M. & Wendelaar Bonga S.E. (1994) Adaptation of freshwater fish to toxicants: stress mechanisms induced by branchial malfunction. In: Sublethal and Chronic Effects of Pollutants on Freshwater Fish (ed. by R. Muller & R. Lloyd), pp. 124-134. Fishing News Books, Oxford.
19. MacKintosh C., Beattie K.A., Klumpp S., Cohen P. & Codd G.A. (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2 A from both mammals and higher plants. FEBS Letters 264, 187-192.
20. Matsushima R., Yoshizawa S., Waranabe M.F., Harada K.I., Furusawa M., Carmichael W.W. & Fujiki H. (1990) In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin fibroblasts. Biochemical and Biophysical Research Communications 171, 867-874.
21. Meriluoto J.A.O., Sandstrom A., Eriksson J.E., Remaud G., Craig J. & Chattopadhyaya J. (1989) Structure and toxicity of a peptide hepatotoxin from the cyanobacterium Oscillatoria agardhii. Toxicon 27, 1021-1034.
22. Penaloza R., Rojas M., Vila I. & Zambrano F. (1990) Toxicity of a soluble peptide from Microcysris sp. to Zooplankton and fish. Freshwater Biology 24, 233-240.
23. Pickering A.D. (1989) Environmental stress and the survival of brown trout Salmo trutta. Freshwater Biology 21, 47-55.
24. Râbergh C.M.I., Bylund G. & Eriksson J.E. (1991) Histopathological effects of microcystin-LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa on common carp (Cyprinus carpio L.). Aquatic Toxicology 20, 131-146.
25. Randall D. (1982) Blood flow through gills. In: Gills (ed. by D.F. Houlihan, J.C. Rankin & T.J. Shuttleworth), pp. 173-191. Cambridge University Press, Cambridge.
26. Rodger H.D., Turnbull T., Edwards C. & Codd G.A. (1994) Cyanobacrerial (blue-green alga) bloom associated pathology in brown trout, Salmo trutta L., in Loch Leven, Scotland. Journal of Fish Diseases 17, 177-181.
27. Schwimmer M. & Schwimmer D. (1968) Medical aspects of phycology. In: Algae, Man and the Environment (ed by D.F. Jackson), pp. 279-358. Syracuse University Press, Syracuse, NY.
28. Soivio A., Nynholm K. & Westman K. (1975) A technique for repeated sampling of the blood from individual resting fish. Journal of Experimental Biology 62, 207-217.
29. Tencalla F.G., Dietrich D.R. & Schlatter C. (1994) Toxicity of Microcystis aeruginosa peptide toxin to yearling rainbow trout (Oncorhynchus mykiss) Aquatic Toxicology 30, 215-224.
30. Toranzo A.E., Nieto F. & Barja J.L. (1990) Mortality associated with cyanobacterial bloom in farmed rainbow trout in Galicia (North-western, Spain). Bulletin of the European Association of Fish Pathologists 10, 106-107.
31. Vittozzi L. & De Angelis G. (1991) A critical review of comparative acute toxicity data on freshwater fish. Aquatic Toxicology 19, 167-204.
32. Williams D.E., Kent M.L., Andersen R.J., Klix H. & Holmes C.F.B. (1995) Tissue distribution and clearance of tritium-labelled dihydromicrocystin-LR epimers administered to Atlantic salmon via intraperitoneal injection. Toxicon 33, 125-134.
33. Wolf K. (1963) Physiological salines fot freshwater teleosts. Progressive Fish-Culturist 25, 135-140.