Tumor necrosis factor-α receptor 1 (p55) knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons

European Journal of Neuroscience

Volumn 22, Issue 1, 2005, Pages 267-272

  Wessig, Jan ^a,b   Brecht, Stephan ^a,c   Claussen, Malte ^a   Roemer, Lutz ^a   Goetz, Mario ^a   Bigini, Paolo ^d   Schutze, Stephan ^a   Herdegen, Thomas ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Apoptosis; c Jun N terminal kinases; Cell body response; Medial forebrain bundle; Mouse; Parkinson's disease

Indexed keywords

ECTODYSPLASIN A; PROTEIN C JUN; PROTEIN P55; PROTEIN P75; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOREACTIVITY; KNOCKOUT MOUSE; MEDIAL FOREBRAIN BUNDLE; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; WILD TYPE;

ANIMALS; AXONS; AXOTOMY; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ECTODYSPLASINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEDIAL FOREBRAIN BUNDLE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE DEGENERATION; PARKINSONIAN DISORDERS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SUBSTANTIA NIGRA; TIME FACTORS; TUMOR NECROSIS FACTOR DECOY RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 23044499795     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04184.x     Document Type: Article

References (50)

1. Behrens, A., Sibilia, M. & Wagner, E.F. (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet., 21, 326-329.
2. Bette, M., Kaut, O., Schafer, M.K. & Weihe, E. (2003) Constitutive expression of p55TNFR mRNA and mitogen-specific up-regulation of TNF alpha and p75TNFR mRNA in mouse brain. J. Comp. Neurol., 465, 417-430.
3. Bigini, P. & Mennini, T. (2004) Immunohistochemical localization of TNFalpha and its receptors in the rodent central nervous system. Meth. Mol. Med., 98, 73-80.
4. Brecht, S., Kirchhof, R., Chromik, A., Willesen, M., Nicolaus, T., Raivich, G., Wessig, J., Waetzig, V., Goetz, M., Claussen, M., Pearse, D., Kuan, C.Y., Vaudano, E., Behrens, A., Wagner, E., Flavell, R.A., Davis, R.A. & Herdegen, T. (2005) Specific pathophysiological functions of JNK isoforms in the brain. Eur. J. Neurosci., 21, 363-377.
5. Chen, G. & Goeddel, D.V. (2002) TNF-R1 signaling: a beautiful pathway. Science, 296, 1634-1635.
6. Coffey, E.T., Smiciene, G., Hongisto, V., Cao, J., Brecht, S., Herdegen, T. & Courtney, M.J. (2002) c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. J. Neurosci., 22, 4335-4345.
7. Crocker, S.J., Lamba, W.R., Smith, P.D., Callaghan, S.M., Slack, R.S., Anisman, H. & Park, D.S. (2001) c-Jun mediates axotomy-induced dopamine neuron death in vivo. Proc. Natl Acad. Sci. U.S.A., 98, 13 385-13 390.
8. Diem, R., Meyer, R., Weishaupt, J.H. & Bahr, M. (2001) Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. J. Neurosci., 21, 2058-2066.
9. Dietrich, N., Holmberg, C., Gyrd, M., Thastrup, J., Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T. (2004) JNK2 is mediating TNF-induced cell death in mouse embryonic fibroblasts via regulating the activation of both caspase and cathepsine protease pathways. Cell Death and Differentiation, 11, 301-313.
10. Dziewulska, D. & Mossakowski, M.J. (2003) Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke. Clin. Neuropathol., 22, 35-40.
11. Eminel, S., Klettner, A., Roemer, L., Herdegen, T. & Waetzig, V. (2004) JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells following 6-hydroxydopamine. J. Biol Chem., 279, 55385-55392.
12. Fontaine, V., Mohand-Said, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K. & Eisel, U. (2002) Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J. Neurosci., 22, RC216.
13. Heller, R.A. & Kronke, M. (1994) Tumor necrosis factor receptor-mediated signaling pathways. J. Cell Biol., 126, 5-9.
14. Henshall, D.C., Araki, T., Schindler, C.K., Shinoda, S., Lan, J.Q. & Simon, R.P. (2003) Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J. Neurochem., 86, 1260-1270.
15. Herdegen, T. & Leah, J.D. (1998) Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res. Brain Res. Rev., 28, 370-490.
16. Herdegen, T. & Waetzig, V. (2001a) AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene, 20, 2424-2437.
17. Herdegen, T. & Waetzig, V. (2001b) The JNK and p38 signal transduction following axotomy. Restor. Neurol. Neurosci., 19, 29-39.
18. Herdegen, T., Brecht, S., Mayer, B., Leah, J., Kummer, W., Bravo, R. & Zimmermann, M. (1993a) Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy. J. Neurosci., 13, 4130-4145.
19. Herdegen, T., Fiallos-Estrada, C.E., Bravo, R. & Zimmermann, M. (1993b) Colocalisation and covariation of c-JUN transcription factor with galanin in primary afferent neurons and with CGRP in spinal motoneurons following transection of rat sciatic nerve. Brain Res. Mol. Brain Res., 17, 147-154.
20. Herdegen, T., Skene, P. & Bahr, M. (1997) The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci., 20, 227-231.
21. Herdegen, T., Claret, F.X., Kallunki, T., Martin-Villalba, A., Winter, C., Hunter, T. & Karin, M. (1998) Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J. Neurosci., 18, 5124-5135.
22. Hermann, G.E., Hebert, S.L., Van Meter, M.J., Holmes, G.M. & Rogers, R.C. (2004) TNF alpha-p55 receptors: medullary brainstem immunocytochemical localization in normal and vagus nerve-transected rats. Brain Res., 1004, 156-166.
23. Hunot, S., Vila, M., Teismann, P., Davis, R.J., Hirsch, E.G., Przedborski, S., Rakic, P. & Flavell, R.A. (2004) JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc. Natl Acad. Sci. U.S.A., 101, 665-670.
24. Ip, Y.T. & Davis, R.J. (1998) Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol., 10, 205-219.
25. Kuan, C.Y., Yang, D.D., Samanta Roy, D.R., Davis, R.J., Rakic, P. & Flavell, R.A. (1999) The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron, 22, 667-676.
26. Kuan, C.Y., Whitmarsh, A.J., Yang, D.D., Liao, G., Schloemer, A.J., Dong, C., Bao, J., Banasiak, K.J., Haddad, G.G., Flavell, R.A., Davis, R.J. & Rakic, P. (2003) A critical role of neural-specific JNK3 for ischemic apoptosis. Proc. Natl Acad. Sci. U.S.A., 100, 15 184-15 189.
27. Levade, T. & Jaffrezou, J.P. (1999) Signalling sphingomyelinases: which, where, how and why? Biochim. Biophys. Acta, 1438, 1-17.
28. Li, R., Yang, L., Lindholm, K., Konishi, Y., Yue, X., Hampel, H., Zhang, D. & Shen, Y. (2004) Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death. J. Neurosci., 24, 1760-1771.
29. Liu, Z.G. (2003) Adding facets to TNF signaling. The JNK angle. Mol. Cell, 12, 795-796.
30. Manning, A.M. & Davis, R.J. (2003) Targeting JNK for therapeutic benefit: from junk to gold? Nat. Rev. Drug Discov., 2, 554-565.
31. Mennini, T., Bigini, P., Cagnotto, A., Carvelli, L., Di Nunno, P., Fumagalli, E., Tortarolo, M., Buurman, W.A., Ghezzi, P. & Bendotti, C. (2004) Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice. Cytokine, 25, 127-135.
32. Mielke, K. & Herdegen, T. (2002) Fatal shift of signal-transduction is an integrate part of neuronal differentiation: JNKs realize TNFα-mediated apoptosis in neuron-like, but not naive, PC12 cells. Mol. Cell. Neurosci., 20, 211-224.
33. Morrison, D.K. & Davis, R.J. (2003) Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol., 19, 91-118.
34. Nagatsu, T., Mogi, M., Ichinose, H. & Togari, A. (2000) Changes in cytokines and neurotrophins in Parkinson's disease. J. Neur. Transm., 60, 277-290.
35. Pantano, C., Shrivastava, P., McElhinney, B. & Janssen-Heininger, Y. (2003) Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase. J. Biol. Chem., 278, 44 091-44 096.
36. Pfeffer, K., Matsuyama, T., Kundig, T.M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P.S., Kronke, M. & Mak, T.W. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell, 73, 457-467.
37. Raivich, G., Liu, Z.Q., Kloss, C.U., Labow, M., Bluethmann, H. & Bohatschek, M. (2002) Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse. Exp. Neurol., 178, 186-193.
38. Raivich, G., Bohatschek, M., Da Costa, C., Iwata, O., Galiano, M., Hristova, M., Nateri, A.S., Makwana, M., Riera-Sans, L., Wolfer, D.P., Lipp, H.P., Aguzzi, A., Wagner, E.F. & Behrens, A. (2004) The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron, 43, 57-67.
39. Rousselet, E., Callebert, J., Parain, K., Joubert, C., Hunot, S., Hartmann, A., Jacque, C., Perez-Diaz, F., Cohen-Salmon, C., Launay, J.M. & Hirsch, E.C. (2002) Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP. Exp. Neurol., 177, 183-192.
40. Sairanen, T.R., Lindsberg, P.J., Brenner, M., Carpen, O. & Siren, A. (2001) Differential cellular expression of tumor necrosis factor-alpha and type I tumor necrosis factor receptor after transient global forebrain ischemia. J. Neurol. Sci., 186, 87-99.
41. Saporito, M.S., Brown, E.M., Miller, M.S. & Carswell, S. (1999) CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J. Pharmacol. Exp. Ther., 288, 421-427.
42. Shinoda, S., Skradski, S.L., Araki, T., Schindler, C.K., Meller, R., Lan, J.Q., Taki, W., Simon, R.P. & Henshall, D.C. (2003) Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur. J. Neurosci., 17, 2065-2076.
43. Shubayev, V.I. & Myers, R.R. (2002) Anterograde TNF alpha transport from rat dorsal root ganglion to spinal cord and injured sciatic nerve. Neurosci. Lett., 320, 99-101.
44. Sriram, K., Matheson, J.M., Benkovic, S.A., Miller, D.B., Luster, M.I. & O'Callaghan, J.P. (2002) Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. Faseb J., 16, 1474-1476.
45. Tezel, G., Yang, X., Yang, J. & Wax, M.B. (2004) Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice. Brain Res., 996, 202-212.
46. Varfolomeev, E.E. & Ashkenazi, A. (2004) Tumor necrosis factor: an apoptosis JuNKie? Cell, 116, 491-497.
47. Waetzig, V. & Herdegen, T. (2003) A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death. J. Biol. Chem., 278, 567-572.
48. Winter, C., Schenkel, J., Burger, E., Eickmeier, C., Zimmermann, M. & Herdegen, T. (2000) The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. Neuroscience, 95, 753-762.
49. Yang, L., Lindholm, K., Konishi, Y., Li, R. & Shen, Y. (2002) Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways. J. Neurosci., 22, 3025-3032.
50. Yang, X., Khosravi-Far, R., Chang, H.Y. & Baltimore, D. (1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell, 89, 1067-1076.