Methionine restriction selectively targets thymidylate synthase in prostate cancer cells

Biochemical Pharmacology

Volumn 66, Issue 5, 2003, Pages 791-800

  Lu, Shan ^a   Chen, George L ^a   Ren, Chengxi ^a   Kwabi Addo, Bernard ^a   Epner, Daniel E ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Folate; Methionine; Prostate neoplasms; Thymidylate synthase

Indexed keywords

FLUOROURACIL; LEUCINE; METHIONINE; METHYLENETETRAHYDROFOLIC ACID; THYMIDYLATE SYNTHASE; TRITIUM;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; FOLIC ACID BLOOD LEVEL; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE EPITHELIUM; PROTEIN SYNTHESIS INHIBITION; REDUCTION; TARGET CELL; WESTERN BLOTTING;

EID: 0042430638     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00406-4     Document Type: Article

References (49)

1. Stern P.H., Hoffman R.M. Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect. J. Natl. Cancer Inst. 76:1986;629-639.
2. Du Vigneaud V., Chandler J.P., Moyer A.W., Keppel D.M. The effect of choline on the ability of homocysteine to replace methionine in the diet. J. Biol. Chem. 131:1939;57-76.
3. Breillout F., Hadida F., Echinard-Garin P., Lascaux V., Poupon M.F. Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet. Anticancer Res. 7:1987;861-867.
4. Tisdale M.J. Utilization of preformed and endogenously synthesized methionine by cells in tissue culture. Br. J. Cancer. 49:1984;315-320.
5. Halpern B.C., Clark B.R., Hardy D.N., Halpern R.M., Smith R.A. The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture. Proc. Natl. Acad. Sci. U.S.A. 71:1974;1133-1136.
6. Mecham J.O., Rowitch D., Wallace C.D., Stern P.H., Hoffman R.M. The metabolic defect of methionine dependence occurs frequently in human tumor cell lines. Biochem. Biophys. Res. Commun. 117:1983;429-434.
7. Tisdale M., Eridani S. Methionine requirement of normal and leukaemic haemopoietic cells in short term cultures. Leuk. Res. 5:1981;385-394.
8. Guo H.Y., Herrera H., Groce A., Hoffman R.M. Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture. Cancer Res. 53:1993;2479-2483.
9. Poirson-Bichat F., Gonfalone G., Bras-Goncalves R.A., Dutrillaux B., Poupon M.F. Growth of methionine-dependent human prostate cancer (PC-3) is inhibited by ethionine combined with methionine starvation. Br. J. Cancer. 75:1997;1605-1612.
10. Guo H., Lishko V.K., Herrera H., Groce A., Kubota T., Hoffman R.M. Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo. Cancer Res. 53:1993;5676-5679.
11. Breillout F., Antoine E., Poupon M.F. Methionine dependency of malignant tumors: a possible approach for therapy. J. Natl. Cancer Inst. 82:1990;1628-1632.
12. Kokkinakis D.M., Hoffman R.M., Frenkel E.P., Wick J.B., Han Q., Xu M., Tan Y., Schold S.C. Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice. Cancer Res. 61:2001;4017-4023.
13. Tan Y., Xu M., Guo H., Sun X., Kubota T., Hoffman R.M. Anticancer efficacy of methioninase in vivo. Anticancer Res. 16:1996;3931-3936.
14. Kreis W., Hession C. Biological effects of enzymatic deprivation of L-methionine in cell culture and an experimental tumor. Cancer Res. 33:1973;1866-1869.
15. Tisdale M.J., Jack G.W., Eridani S. Differential sensitivity of normal and leukaemic haemopoietic cells to methionine deprivation by L-methioninase. Leuk. Res. 7:1983;269-277.
16. Yoshioka T., Wada T., Uchida N., Maki H., Yoshida H., Ide N., Kasai H., Hojo K., Shono K., Maekawa R., Yagi S., Hoffman R.M., Sugita K. Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase. Cancer Res. 58:1998;2583-2587.
17. Kokkinakis D.M., Schold S.C.J., Hori H., Nobori T. Effect of long-term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice. Nutr. Cancer. 29:1997;195-204.
18. Goseki N., Yamazaki S., Shimojyu K., Kando F., Maruyama M., Endo M., Koike M., Takahashi H. Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial. Jpn. J. Cancer Res. 86:1995;484-489.
19. Epner D.E., Morrow S., Wilcox M., Houghton J.L. Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction. Nutr. Cancer. 42:2002;158-166.
20. Sugimura T., Birnbaum S.M., Winitz M., Greenstein J.P. Quantitative nutritional studies with water-soluble, chemically defined diets. VIII. The forced feeding of diets each lacking in one essential amino acid. Arch. Biochem. Biophys. 81:1959;448-455.
21. Hoffman R.M. Unbalanced transmethylation and the perturbation of the differentiated state leading to cancer. Bioassays. 12:1990;163-166.
22. Hoffman R.M. Altered methionine metabolism and transmethylation in cancer. Anticancer Res. 5:1985;1-30.
23. Kamely D., Littlefield J.W., Erbe R.W. Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells. Proc. Natl. Acad. Sci. U.S.A. 70:1973;2585-2589.
24. Kutzbach C., Stokstad E.L. Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine. Biochim. Biophys. Acta. 139:1967;217-220.
25. Scott J.M., Weir D.G. The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet. 2:1981;337-340.
26. Carreras C.W., Santi D.V. The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64:1995;721-762.
27. Duthie S.J., Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J. 12:1998;1491-1497.
28. Pogribny I.P., Basnakian A.G., Miller B.J., Lopatina N.G., Poirier L.A., James S.J. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res. 55:1995;1894-1901.
29. Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Wang G., Wickramasinghe S.N., Everson R.B., Ames B.N. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94:1997;3290-3295.
30. Kitchens M.E., Forsthoefel A.M., Barbour K.W., Spencer H.T., Berger F.G. Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. Mol. Pharmacol. 56:1999;1063-1070.
31. Papamichael D. The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status. Oncologist. 4:1999;478-487.
32. Carreras C.W., Santi D.V. The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64:1995;721-762.
33. Lin S.B., Ts'o P.O., Sun S.K., Choo K.B., Yang F.Y., Lim Y.P., Tsai H.L., Au L.C. Inhibition of thymidylate synthase activity by antisense oligodeoxynucleotide and possible role in thymineless treatment. Mol. Pharmacol. 60:2001;474-479.
34. Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirota Y., Ayusawa D., Seno T., Garrett C., Wataya Y. Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J. Biol. Chem. 262:1987;8235-8241.
35. Mini E., Trave F., Rustum Y.M., Bertino J.R. Enhancement of the antitumor effects of 5-fluorouracil by folinic acid. Pharmacol. Ther. 47:1990;1-19.
36. Bertino J.R., Romanini A. Modulation of fluoropyrimidines by pretreatment with antifolates or folinic acid (leucovorin). Cancer Invest. 8:1990;259-260.
37. Machover D., Zittoun J., Broet P., Metzger G., Orrico M., Goldschmidt E., Schilf A., Tonetti C., Tan Y., Delmas-Marsalet B., Luccioni C., Falissard B., Hoffman R.M. Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid. Biochem. Pharmacol. 61:2001;867-876.
38. Burke G.T., Mangum J.H., Brodie J.D. Mechanism of mammalian cobalamin-dependent methionine biosynthesis. Biochemistry. 10:1971;3079-3085.
39. Finkelstein J.D. Methionine-sparing effect of cystine in human subjects. Am. J. Clin. Nutr. 68:1998;224-225.
40. Mini E., Mazzei T., Coronnello M., Criscuoli L., Gualtieri M., Periti P., Bertino J.R. Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells. Biochem. Pharmacol. 36:1987;2905-2911.
41. Hoshiya Y., Kubota T., Inada T., Kitajima M., Hoffman R.M. Methionine-depletion modulates the efficacy of 5-fluorouracil in human gastric cancer in nude mice. Anticancer Res. 17:1997;4371-4375.
42. Goseki N., Endo M., Onodera T., Kosaki G. Anti-tumor effect of L-methionine-deprived total parenteral nutrition with 5-fluorouracil administration on Yoshida sarcoma-bearing rats. Ann. Surg. 214:1991;83-88.
43. Van der Wilt C.L., Pinedo H.M., Smid K., Peters G.J. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res. 52:1992;4922-4928.
44. Cross D.R., Miller B.J., James S.J. A simplified HPLC method for simultaneously quantifying ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues. Cell Prolif. 26:1993;327-336.
45. Dong Z.Y., Ward N.E., Fan D., Gupta K.P., O'Brian C.A. In vitro model for intrinsic drug resistance: effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells. Mol. Pharmacol. 39:1991;563-569.
46. Tan Y., Zavala J.S., Han Q., Xu M., Sun X., Tan X., Magana R., Geller J., Hoffman R.M. Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients. Anticancer Res. 17:1997;3857-3860.
47. Tisdale M.J. Effect of methionine deprivation on methylation and synthesis of macromolecules. Br. J. Cancer. 42:1980;121-128.
48. Johnston P.G., Lenz H.J., Leichman C.G., Danenberg K.D., Allegra C.J., Danenberg P.V., Leichman L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res. 55:1995;1407-1412.
49. Parr A.L., Drake J.C., Gress R.E., Schwartz G., Steinberg S.M., Allegra C.J. 5-Fluorouracil-mediated thymidylate synthase induction in malignant and nonmalignant human cells. Biochem. Pharmacol. 56:1998;231-235.