Methionine-depletion modulates the efficacy of 5-fluorouracil in human gastric cancer in nude mice

Anticancer Research

Volumn 17, Issue 6 D, 1997, Pages 4371-4375

  Hoshiya, Yasunori ^a   Kubota, Tetsuro ^a   Inada, Takao ^b   Kitajima, Masaki ^a   Hoffman, Robert M ^c  

^a KEIO UNIVERSITY   (Japan)

^b TOCHIGI CANCER CENTER   (Japan)

^c ANTICANCER INC   (United States)

Author keywords

5 FU; Folates; Methionine dependence; Modulation; Nude mice; Stomach cancer; Thymidylate synthetase

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLIC ACID; FOLINIC ACID; METHIONINE; THYMIDYLATE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CELL GROWTH; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFICACY; ENZYME ACTIVITY; FOLATE METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; STOMACH CANCER; XENOGRAFT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROURACIL; FOLIC ACID; HUMANS; MALE; METHIONINE; MICE; MICE, NUDE; STOMACH NEOPLASMS; THYMIDYLATE SYNTHASE; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0031409710     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Hoffman RM: Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis: a review and synthesis. Biochem et Biophys Acta Reviews of Cancer 738: 49-87, 1984.
2. Guo HY, Herrera H, Groce A, and Hoffman RM: Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture. Cancer Res 55: 2479-2483, 1993.
3. Hoshiya Y, Guo HY, Kubota T, Inada T, Asanuma F, Yamada Y, Koh J, Kitajima M, and Hoffman RM: Human tumors are methionine-dependent in vivo. Anticancer Res 15: 717-718, 1995.
4. Hoffman RM and Jacobsen SJ: Reversible growth arrest in SV40-transformed human fibroblasts. Proc Natl Acad Sci USA 77: 7306-7310, 1980.
5. Guo HY, Lishko VK, Herrera H, Groce A, Kubota T, and Hoffman RM: Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo. Cancer Res 53: 5676-5679, 1993.
6. Stern PH and Hoffman, RM: Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect. J Natl Cancer Inst 76: 629-639, 1986.
7. Stern PH and Hoffman RM: Elevated rates of transmethylation in cell lines from diverse human tumors. In vitro - Rapid Commun Cell Biol 20: 663-670, 1984.
8. Geran RI, Greenberg NH, Macdonald MM, Schumacher AM, and Abbott BJ: Protocols for screening chemical agents and natural products against animal tumors and other biological systems (third edition). Cancer Chemother Rep 3: 51-61, 1972.
9. Berenbaum MC: Criteria for analyzing interactions between biologically active agents. Adv Cancer Res 35: 269-335, 1981.
10. Spears CP, Shahinian Am, Moran RG, Heidelberger C, and Corgett TH. In vivo kinetics of thymidylate synthetase inhibition of 5-fluouracil-sensitive and -resistant murine colon adenocarcinomas. Cancer Res 42: 450-456, 1982.
11. Spears CP, Gustavsson BG, Mitchell MS, Spicer D, Berne M, Bernstein L, and Danenberg PV: Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluouracil. Cancer Res 44: 4144-4150, 1984.
12. Kubota T, Fujita S, Kodaira S, Yamamoto T, Josui K, Arisawa Y, Suto A, Ishibiki K, Abe O, Mabuchi K, and Fuse M Antitumor activity of fluoropyrimidines and thymidylate synthetase inhibition. Jpn J Cancer Res 82: 476-482, 1991.
13. Hoshiya Y, Kubota T, Matsuzaki SW, Kitajima M and Hoffman RM: Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice. Anticancer Res 16: 3515-3518, 1996.
14. Scanlon KJ, Newman EM, Lu Y, and Priest DG: Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. Proc Natl Acad Sci USA 83: 8923-2825, 1986.
15. Hibino Y, Kawarabayashi Y, Kohri H, Ueda N and Tsukagoshi S: The mechanism of potentiation of the antitumor effect of 5-fluorouracil by methionine-free intravenous amino acid solution (AO-90) in rats. Jpn J Cancer Chemother 21: 2021-2028, 1994. (In Japanese with English abstract)
16. Taguchi T, Kosaki G, Onodera T, et al: A controlled study of AO-90, a methionine-free intravenous amino acid solution, in combination with 5-fluorouracil and mitomycin C in advanced gastric cancer patients (Surgery group evaluation). Jpn J Cancer Chemother 22: 753-764, 1995.
17. Goseki N, Yamazaki S, Shimojyu K, Kando F, Maruyama M, Endo M, Koike M, Takahashi H. Synergistic effect of methionine-depleting total parental nutrition with 5-fluorouracil on human gastric cancer: a randomized prospective clinical trial. Jpn J Cancer Res 86: 484-489, 1995.
18. Tan Y, Zavala J Sr, Xu M, Zavala J Jr and Hoffman RM: Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients. Anticancer Res 16: 3937-3942, 1996.
19. Tan Y, Xu M, Tan X, Wang X, Saikawa Y, Nagahama T, Sun X, Lenz M and Hoffman RM: Overexpression and large-scale production of recombinant L-methionine-α-deamino-γ-mercaptomethane-lyase for novel anticancer therapy. Protein Expression and Purification 9: 233-245, 1997.
20. Hoffman RM: Recombinant methioninase. Drugs of the Future 22: 130-134, 1997.
21. Piedbois P, Buyse M, Rustum YM, Machover D: The advanced colorectal cancer metaanalysis project. Modulation of 5-fluorouracil by leucovorin in patients with advanced colorectal cancer. Evidence in terms of response rate. J Clin Oncol 10: 896-903, 1992.
22. Machover D, Grison X, Goldschmidt E, et al: 5-Fluorouracil combined with the pure [6S]stereoisomer of folinic acid in high doese for treatment of patients with advanced colorectal carcinoma. A phase I-II study. J Natl Cancer Inst 84: 321-327, 1992.
23. Machover D, Goldschmidt E, Tourani JM, et al: Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil combined with high-dose folinic acid. A pilot study. Cancer Treat Rep 66: 1803-1807, 1982.
24. Machover D, Goldschmidt E, Chollet P: Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid. J Clin Oncology 4: 685-696, 1996.
25. Danenberg PV, Danenberg KD: Effect of 5,10-methylenete-trahydrofolate on the dissociation of 5-fluoro-2′-deoxyuridylate from thymidylate synthetase: Evidence of an ordered mechanism. Biochemistry 17: 4018-4024, 1978.
26. Lockshin A, Danenberg PV: Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase. Biochemical Pharmacology 30: 247-257, 1981.
27. Yin MB, Zakrzewski SF, Hakala MT: Relationship of cellular folate co-factor pools to the activity of 5-fluorouracil. Molecular Pharmacology 23: 190-197, 1983.
28. Houghton JA, Williams LG, de Graaf SSN, Cheshire PJ, et al: Comparison of the conversion of 5-formyltetrahydrofolate and 5-methyltetrahydrofolate to 5, 10-methylenetetrahydrofolates and tetrahydrofolates in human colon tumors. Cancer Communications 11: 167-174, 1989.
29. Voeller DM, Allegra CJ: Intracellular metabolism of 5-methyltetrahydrofolate and 5-formyltetrahydrofolate in a human breast-cancer cell line. Cancer Chemother Pharmacol 34: 491-496, 1994.
30. Priest D, Schmitz JC, Bunni MA: Folate metabolites as modulators of antitumor drug activity. In: Chemistry and Biology of Pteridines and Folates, JE Ayling et al: Plenum Press, New York, 1993, pp 693-697.
31. Boarman DM, Allegra CJ: Intracellular metabolism of 5-formyltetrahydrofolate in human breast and colon cell lines. Cancer Res 52: 36-44, 1992.
32. Schilsky RL, Ratain MJ: Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. J Natl Cancer Inst 82: 1411-1415, 1990.
33. Finkelstein JD: Methionine metabolism in mammals. J Nutr Biochem 1: 228-237, 2990.
34. Sobrero AF, Aschele C, Bertino JR: Fluorouracil in colorectal cancer - A tale of two drugs: Implication for biochemical modulation. J Clin Oncol 15: 368-381, 1997.
35. Rustum YM, Harstrick A, Cao S, Vanhoefer U, Yin M-B, Wilkie H, Seefer S: Thymidylate synthetase inhibitors in cancer therapy: Direct and indirect inhibitors. J Clin Oncol 15: 389-400, 1997.
36. Kamely D, Littlefield JW, Erbe RW: Regulation of 5-methyltetrahytdrofolate:homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells. Proc Natl Acad Sci USA 70: 2585-2589, 1973.
37. Hoffman RM: Methioninase: A therapeutic for diseases related to altered methionine. metabolism and transmethylation: Cancer, Heart disease, Obesity, Aging, and Parkinson's Disease. Human Cell 10: 69-80, 1997.
38. Tan Y, Xu M, Sun X, Kubota T and Hoffman RM: Anticancer efficacy of methioninase in vivo. Anticancer Res 16: 3931-3936, 1996.