Hyperhomocysteinaemia is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients

European Journal of Neurology

Volumn 15, Issue 3, 2008, Pages 289-294

  Shimomura, T ^a,b   Anan, F ^a,b   Umeno, Y ^a   Eshima, N ^c   Saikawa, T ^b   Yoshimatsu, H ^b   Fujiki, M ^b   Kobayashi, H ^b  

^a OITA RED CROSS HOSPITAL   (Japan)

^b OITA UNIVERSITY   (Japan)

^c OITA UNIVERSITY   (Japan)

Author keywords

Homocysteine; Insulin resistance; Type 2 diabetes mellitus; White matter lesions

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; TRIACYLGLYCEROL;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; BRAIN DAMAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; IMMUNOREACTIVITY; INSULIN RESISTANCE; JAPANESE; LOGISTIC REGRESSION ANALYSIS; MALE; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; UNIVARIATE ANALYSIS; WHITE MATTER; WHITE MATTER LESION;

BLOOD GLUCOSE; BRAIN DISEASES; DIABETES MELLITUS, TYPE 2; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INSULIN RESISTANCE; JAPAN; LOGISTIC MODELS; MALE; MIDDLE AGED; NEUROGLIA; RISK FACTORS;

EID: 39149123826     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02062.x     Document Type: Article

References (38)

1. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. Stroke 1995 26 : 1293 1301.
2. Wong TY, Klein R, Sharrett AR, et al. Cerebral white matter lesions, retinopathy, and incident clinical stroke. The Journal of the American Medical Association 2002 288 : 67 74.
3. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke 2003 34 : 1126 1129.
4. Longstreth WT Jr., Manolio TA, Arnold A, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996 27 : 1274 1282.
5. Schmidt R, Launer LJ, Nilsson LG, et al., CASCADE Consortium A magnetic resonance imaging of midlife blood pressure to late-life cognitive decline and brain morphology. Diabetes 2004 53 : 687 692.
6. The Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. The Journal of the American Medical Association 2002 288 : 2015 2022.
7. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. British of Medical Journal 2002 325 : 1202 1206.
8. Vermeer SE, van Dijk EJ, Koudstaal PJ, et al. Homocysteine, silent brain infarcts, and white matter lesions: the Rotterdam Scan Study. Annals of neurology 2002 51 : 285 289.
9. Wright CB, Paik MC, Brown TR, et al. Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke 2005 36 : 1207 1211.
10. Dufouil C, Alpérovitch A, Ducros V, Tzourio C. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Annals of neurology 2003 53 : 214 221.
11. Reaven GM. Role of insulin resistance in human disease. Diabetes 1998 37 : 1595 1607.
12. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991 14 : 173 194.
13. Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study. Journal of American College of Cardiology 2007 49 : 2112 2119.
14. Liao D, Sloan RP, CaWMLo WE, et al. Multiple metabolic syndrome is associated with lower heart rate variability. The Atherosclerosis Risk in Communities Study. Diabetes Care 1998 21 : 2116 2122.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 419.
16. Taniguchi A, Fukushima M, Sakai M, et al. Remnant-like particle cholesterol, triglyceride, and insulin resistance in nonobese Japanese type 2 diabetic patients. Diabetes Care 2000 23 : 1766 1769.
17. Donnelly JG, Pronovost C. Evaluation of the Abbott IMx fluorescence polarization immunoassay and the Bio-Rad enzyme immunoassay for homocysteine: comparison with high-performance liquid chromatography. Annals of Clinical Biochemistry 2000 37 : 194 198.
18. Davies L, Wilmshurst EG, McElduff A, Gunton J, Clifton-Bligh P, Fulcher GR. The relationship among homocysteine, creatinine clearance, and albuminuria in patients with type 2 diabetes. Diabetes Care 2001 24 : 1805 1809.
19. Breteler MM, van Swieten JC, Bots ML, et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994 44 : 1246 1252.
20. Shimada K, kawamoto A, Matsubayashi K, Ozawa T. Silent cerebrovascular disease in the elderly. Correlation with ambulatory pressure. Hypertension 1990 16 : 692 699.
21. Sierra C, De la Sierra A, Mercader J, Gómez-Angelats E, Urbano-Márquez A, Coca A. Silent cerebral white matter lesions in middle-aged essential hypertensive patients. Journal of Hypertension 2002 20 : 519 524.
22. Okamura T, Kitamura A, Moriyama Y, et al. Plasma level of homocysteine is correlated to extracranial carotid-artery atherosclerosis in non-hypertensive Japanese. Journal of Cardiovascular Risk 1999 6 : 371 377.
23. Stamler JS, Osborne JA, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated of nitrogen endothelium-derived relaxing factor and related oxides of nitrogen. Journal of Clinical Investigation 1993 91 : 308 318.
24. Dardik R, Varon D, Tamarin I, et al. Homocysteine and oxidized low density enhanced platelet adhesion to endothelial cells under flow conditions: distinct mechanisms of thrombogenic modulation. Thrombosis and Haemostasis 2000 83 : 338 344.
25. Tsai JC, Perrella MA, Yoshizumi M, et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America 1994 91 : 6369 6373.
26. Schreiner PJ, Wu KK, Malinow MR, et al. Hyperhomocyst(e)inemia and hemostatic factors: the atherosclerosis risk in communities study. Annals of Epidemiology 2002 12 : 228 236.
27. Hassan A, Hunt BJ, O'Sullivan M, et al. Homocysteine is arisk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 2004 127 : 212 219.
28. Schmidt R, Launer LJ, Nilsson LG, et al. CASCADE Consortium. Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes 2004 53 : 687 692.
29. Jongen C, van der Grond J, Kappelle LJ, et al., on behalf of the Utrecht Diabetic Encephalopathy Study Group. Automated measurement of brain and white matter lesion volume in type 2 diabetes mellitus. Diabetologia 2007 50 : 1509 1516.
30. Jacobs RL, House JD, Brosnan ME, Brosnan JT. Effects of streptozotocin-induced diabetes and insulin treatment on homocysteine metabolism rat. Diabetes 1998 47 : 1967 1970.
31. Fonseca V, Dicker-Brown A, Ranganathan S, et al. Effects of a high-fat-sucrose diet on enzymes in homocysteine metabolism in the rat. Metabolism 2000 49 : 736 741.
32. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. Journal of Clinical Investigation 1996 97 : 2601 2610.
33. Hu CT, Chang KC, Wu CY, Chen HI. Acute effects of nitric oxide blockade with L-NAME on arterial haemodynamics in the rat. British of Journal Pharmacology 1997 122 : 1237 1243.
34. Indolfi C, Torella D, Cavuto L, et al. Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. Circulation 2001 103 : 2980 2986.
35. Gavras HP. Issues in hypertension: drug tolerability and special populations. American Journal of Hypertension 2001 14 (Pt 2 231S 236S.
36. Lender D, Arauz-Pacheco C, Breen L, Mora-Mora P, Ramirez LC, Raskin P. A double blind comparison of the effects of amlodipine and enalapril on insulin sensitivity in hypertensive patients. American Journal of Hypertension 1999 12 : 298 303.
37. Moriyama Y, Okamura T, Kajinami K, et al. Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese. Atherosclerosis 2002 164 : 321 328.
38. Arai R, Maruyama C, Igarashi S, et al. Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects. European Journal of Clinical Nutrition 2006 60 : 573 579.