Homocysteine and oxidized low density lipoprotein enhance platelet adhesion to endothelial cells under flow conditions: Distinct mechanisms of thrombogenic modulation

Thrombosis and Haemostasis

Volumn 83, Issue 2, 2000, Pages 338-344

  Dardik, Rima ^b,c   Varon, D ^b   Tamarin, I ^b   Zivelin, A ^b   Salomon, O ^b   Shenkman, B ^b   Savion, N ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b The Amalia Biron Research Institute of Thrombosis and Hemostasis   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

Endothelial cells; Homocysteine oxidized LDL

Indexed keywords

ABCIXIMAB; FIBRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; HOMOCYSTEINE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYCLONAL ANTIBODY; THROMBOPLASTIN;

ARTICLE; BLOOD FLOW; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RISK FACTOR; SHEAR RATE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOGENESIS; THROMBOGENICITY;

EID: 0041677489     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613809     Document Type: Article

References (30)

1. McCully KS. Homocysteine and vascular disease. Nature Medicine 1996; 2: 386-9.
2. Moncada S, Palmer RMJ, Higgs EA. Prostacyclin and endothelium-derived relaxing factor: biological interactions and significance. In: Thrombosis and Heamostasis 1987. Verstraete M, Vermylen J, Lijnen R and Arnout J (eds). Leuven: Leuven University Press, pp. 597-618.
3. Lentz SR, Sadler JE. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991; 88: 1906-14.
4. Rodgers GM, Conn MT. Homocysteine, am atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood 1990; 75: 895-901.
5. Ratnoff OD. Activation of Hageman factor by L-homocystine. Science 1968; 162: 1007-9.
6. Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest 1986; 77: 1909-16.
7. Fryer RH, Wilson BD, Gubler DB, Fitzgerald LA, Rodgers GM. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromh 1993; 13: 1327-33.
8. Diquelou A, Dupouy D, Gaspin D, Constans J, Sie P, Boneu B, Sakariassen KS, Cadroy Y. Relationship between endothelial tissue factor and thrombogenesis under blood flow conditions. Thromb Haemost 1995; 74: 778-83.
9. Berliner J, Leitinger N, Watson A, Huber J, Fogelman A, Navah M. Oxidized lipids in atherogenesis: formation, destruction and action. Thromb Haemost 1997; 78: 195-9.
10. Quinn MT, Parthasarathy S, Fong GL, Steinherg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987; 84: 2995-8.
11. Frostegard J, Nilsson J, Haegerstrand A, Hamsten A, Wigzell H, Gidlund M. Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U 937. Proc Natl Acad Sci USA 1990; 87: 904-8.
12. Weber C, Erl W, Weber PC. Enhancement of monocyte adhesion to endothelial cells by oxidatively modified low-density lipoprotein is mediated by activation of CD1 1b. Biochem Biophys Res Commol/Lun 1995; 206: 621-8.
13. Erl W, Weber PC, Weber C. Monocytic cell adhesion to endothelial cells stimulated by oxidized low density lipoprotein is mediated by distinct endothelial ligands. Atherosclerosis 1998; 136: 297-303.
14. 3 integrin and GPIba. J Exp Med 1998; 187: 329-39.
15. 3) mediates platelet adhesion to the luminal aspect of endothelial cells. Implications for reperfusion in acute myocardial infarction. Circulation 1997; 96: 1809-17.
16. Havel RJ, Eder HA, Bragdon JH. Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34: 1345-53.
17. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1976; 52: 302-10.
18. Varon D, Dardik R, Shenkamn B, Kotev-Emeth S, Farzame N, Tamarin I, Savion N. A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions. Thromb Res 1997; 85: 283-94.
19. Varon D, Lashevski I, Brenner B, Beyar R, Lanir N, Tamarin I, Savion N. Cone and plate(let) analyzer: Monitoring glycoprotein IIb/IIIa antagonists and von Willehrand disease replacement therapy by testing platelet deposition under flow conditions. Amer Heart J 1998; 135: S187-93.
20. Lavee J, Martinowitz U, Mohr R, Goor D, Golan M, Langsam J, Malik Z, Savion N. The effect of transfusion of fresh whole blood versus platelet concentrates after cardiac operations. J Thorac Cardiovasc Surg 1989; 97: 204-12.
21. Weiss HJ, Tschopp TB, Rogers J, Brand H. Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism. J Clin Invest 1974; 54: 421-32.
22. Kokame K, Kato H, Miyata T. Homocysteine - respondent genes in vascular endothelial cells identified by differential display analysis. J Biol Chem 1996; 271: 29659-65.
23. Dardik R, Savion N, Kaufmann Y, Varon D. Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under flow conditions: role of platelet glycoproteins P-selectin and GPIIb-IIIa. Br J Cancer 1998; 77: 2069-75.
24. Kaplan JE, Moon DG, Weston LK, Minnear FL, Del Vecchio PJ, Shepard JM, Fenton JW II. Platelets adhere to thrombin-treated endothelial cells in vitro. Am J Physiol 1989; 257: H423-33.
25. Li JL, Podolsky RS, Rohrer MJ, Cutler BS, Massie MT, Barnard MR, Michenson MD. Adhesion of activated platelets to venous endothelial cells is mediated via GPIIb/IIIa. J Surg Res 1996; 61: 543-58.
26. Meyers KM, Holmsen Het, Seachord CL. Comparative study of platelet dense granule constituents. Am J Physiol 1982; 243: 454.
27. Weis JR, Pitas RE, Wilson BD, Rodgers GM. Oxidized LDL increases cultured human endothelial cell tissue factor activity and reduces protein C activation. Faseb J 1991; 5: 2459-65.
28. 3 integrins. Circulation 1998; 98: 1085-91.
29. 3. Thromb Haemost 1998; 79: 998-1003.
30. De Jong SC, Stehouwer CDA, van den Berg M, Vischer UM, Rauwerda JA, Emeis JJ. Endothelial marker proteins in hyperhomocysteinemia. Thromb Haemost 1997; 78: 1332-7.