The metastatic stage-dependent mucosal expression of sialic acid is a potential marker for targeting colon cancer with cationic polymers

Pharmaceutical Research

Volumn 25, Issue 2, 2008, Pages 379-386

  Azab, Abdel Kareem ^a   Kleinstern, Jackie ^a   Srebnik, Morris ^a,b   Rubinstein, Abraham ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b David R Bloom Center for Pharmacy   (Israel)

Author keywords

Cationic polymers; Colon cancer; Drug targeting; Rat model; Sialic acid

Indexed keywords

CATION; COPOLYMER; DIMETHYLHYDRAZINE; DITHIOTHREITOL; FLUORESCEIN ISOTHIOCYANATE; SIALIC ACID; WHEAT GERM AGGLUTININ;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BINDING KINETICS; CANCER ADJUVANT THERAPY; CANCER STAGING; COLON CANCER; COLON POLYP; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG BINDING; DRUG EFFICACY; DRUG TARGETING; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; IONIZATION; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WHEAT GERM;

ACRYLAMIDES; ANIMALS; CELL LINE, TUMOR; COLONIC NEOPLASMS; HUMANS; INTESTINAL MUCOSA; N-ACETYLNEURAMINIC ACID; NEOPLASM METASTASIS; NEOPLASM STAGING; RATS; WHEAT GERM AGGLUTININS;

EID: 39149122202     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9330-4     Document Type: Article

References (33)

1. J. P. Arnoletti, and K. I. Bland. Neoadjuvant and adjuvant therapy for rectal cancer. Surg. Oncol. Clin. N. Am. 15:147-157 (2006).
2. A. B. Benson, 3rd. New approaches to the adjuvant therapy of colon cancer. Oncologist 11:973-980 (2006).
3. R. Duncan, M. J. Vicent, F. Greco, and R. I. Nicholson. Polymer-drug conjugates: towards a novel approach for the treatment of endocrine-related cancer. Endocr. Relat. Cancer 12(Suppl 1):S189-S199 (2005).
4. R. K. Jain. Transport of molecules, particles and cells in solid tumors. Ann. Rev. Biomed. Eng. 1:241-263 (1999).
5. A. Nori, and J. Kopecek. Intracellular targeting of polymer-bound drugs for cancer chemotherapy. Adv. Drug Deliv. Rev. 57:609-636 (2005).
6. A. K. Azab, M. Srebnik, V. Doviner, and A. Rubinstein. Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationized acrylamide copolymers. J. Control. Release 106:14-25 (2005).
7. S. S. Goldman, N. D. Volkow, J. Brodie, and E. S. Flamm. Putrescine metabolism in human brain tumors. J. Neurooncol. 4:23-29 (1986).
8. A. R. Holmberg, M. Wilchek, M. Marquez, J.-E. Westlin, J. Du, and S. Nilsson. Ion exchange tumor targeting: a new approach. Clin. Cancer Res. 5:3056s-3058s (1999).
9. N. D. Volkow, S. S. Goldman, E. S. Flamm, H. Cravioto, A. P. Wolf, and J. Brodie. Labeled putrescine as a probe in brain tumors. Science 221:673-675 (1983).
10. M. Xu, Q. R. Chen, D. Kumar, S. A. Stass, and A. J. Mixson. In vivo gene therapy with a cationic polymer markedly enhances the antitumor activity of antiangiogenic genes. Mol. Genet. Metab. 64:193-197 (1998).
11. C. R. Dass, and P. F. Choong. Targeting of small molecule anticancer drugs to the tumour and its vasculature using cationic liposomes: lessons from gene therapy. Cancer Cell Int. 6:17 (2006).
12. F. Dall'Olio, and D. Trere. Expression of alpha 2,6-sialylated sugar chains in normal and neoplastic colon tissues. Detection by digoxigenin- conjugated Sambucus nigra agglutinin. Eur. J. Histochem. 37:257-265 (1993).
13. M. J. Vierbuchen, W. Fruechtnicht, S. Brackrock, K. T. Krause, and T. J. Zienkiewicz. Quantitative lectin-histochemical and immunohistochemical studies on the occurrence of alpha(2,3)- and alpha(2,6)-linked sialic acid residues in colorectal carcinomas. Relation to clinicopathologic features. Cancer 76:727-35 (1995).
14. K. Yamashita, K. Fukushima, T. Sakiyama, F. Murata, M. Kuroki, and Y. Matsuoka. Expression of Sia alpha 2->6Gal beta 1->4GlcNAc residues on sugar chains of glycoproteins including carcinoembryonic antigens in human colon adenocarcinoma: applications of Trichosanthes japonica agglutinin I for early diagnosis. Cancer Res. 55:1675-1679 (1995).
15. P. Gessner, S. Riedl, A. Quentmaier, and W. Kemmner. Enhanced activity of CMP-neuAc:Gal beta 1-4GlcNAc:alpha 2,6-sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients. Cancer Lett. 75:143-149 (1993).
16. B. P. Peters, S. Ebisu, I. J. Goldstein, and M. Flashner. Interaction of wheat germ agglutinin with sialic acid. Biochemistry 18:5505-5511 (1979).
17. A. Varki. Sialic acids as ligands in recognition phenomena. Faseb J. 11:248-255 (1997).
18. F. Gabor, E. Bogner, A. Weissenboeck, and M. Wirth. The lectin-cell interaction and its implications to intestinal lectin-mediated drug delivery. Adv. Drug Deliv. Rev. 56:459-480 (2004).
19. J. M. Gilbert, E. M. Thompson, G. Slavin, and A. E. Kark. Chemotherapy of chemically-induced colorectal tumours. J. R. Soc. Med. 76:467-472 (1983).
20. J. D. Benson, Y. N. Chen, S. A. Cornell-Kennon, M. Dorsch, S. Kim, M. Leszczyniecka, W. R. Sellers, and C. Lengauer. Validating cancer drug targets. Nature 441:451-456 (2006).
21. U. Vanhoefer. Molecular mechanisms and targeting of colorectal cancer. Semin. Oncol. 32:7-10 (2005).
22. C. R. Dass. Improving anti-angiogenic therapy via selective delivery of cationic liposomes to tumour vasculature. Int. J. Pharm. 267:1-12 (2003).
23. M. Aubery, M. Reynier, M. Lopez, E. Ogier-Denis, J. Font, and F. Bardin. WGA binding to the surface of two autologous human melanoma cell lines: different expression of sialyl and N-acetylglucosaminyl residues. Cell Biol. Int. Rep. 14:275-286 (1990).
24. M. Szeverenyi, R. Osmers, W. Rath, W. Kuhn, and L. Lampe. Changes in binding capacity of sialic acid-specific lectins in the connective tissue of the uterine cervix during its physiological maturation. Acta Physiol. Hung. 82:3-13 (1994).
25. P. de Albuquerque Garcia Redondo, C. V. Nakamura, W. de Souza, and J. A. Morgado-Diaz. Differential expression of sialic acid and N-acetylgalactosamine residues on the cell surface of intestinal epithelial cells according to normal or metastatic potential. J. Histochem. Cytochem. 52:629-640 (2004).
26. K. Chadee, W. A. Petri, Jr., D. J. Innes, and J. I. Ravdin. Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica. J. Clin. Invest. 80:1245-1254 (1987).
27. T. A. Saldena, F. D. Saravi, O. R. Arrieta, L. M. Cincunegui, and G. E. Carra. Effect of dithiothreitol on mucus gel layer and electrophysiological properties in rat colon. Rev. Esp. Fisiol. 53:385-386 (1997).
28. R. B. Campbell, D. Fukumura, E. B. Brown, L. M. Mazzola, Y. Izumi, R. K. Jain, V. P. Torchilin, and L. L. Munn. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 62:6831-6836 (2002).
29. S. K. Lai, D. E. O'Hanlon, S. Harrold, S. T. Man, Y. Y. Wang, R. Cone, and J. Hanes. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. U. S. A. 104:1482-1487 (2007).
30. A. C. Alder, E. C. Hamilton, T. Anthony, and G. A. Sarosi, Jr. Cancer risk in endoscopically unresectable colon polyps. Am. J. Surg. 192:644-648 (2006).
31. M. Betes Ibanez, M. A. Munoz-Navas, J. M. Duque, R. Angos, E. Macias, J. C. Subtil, M. Herraiz, S. de la Riva, M. Delgado-Rodriguez, and M. A. Martinez-Gonzelez. Diagnostic value of distal colonic polyps for prediction of advanced proximal neoplasia in an average-risk population undergoing screening colonoscopy. Gastrointest. Endosc. 59:634-641 (2004).
32. L. F. Butterly, M. P. Chase, H. Pohl, and G. S. Fiarman. Prevalence of clinically important histology in small adenomas. Clin. Gastroenterol. Hepatol. 4:343-348 (2006).
33. I. C. Lawrance, C. Sherrington, and K. Murray. Poor correlation between clinical impression, the small colonic polyp and their neoplastic risk. J. Gastroenterol. Hepatol. 21:563-568 (2006).