In vivo gene therapy with a cationic polymer markedly enhances the antitumor activity of antiangiogenic genes

Molecular Genetics and Metabolism

Volumn 64, Issue 3, 1998, Pages 193-197

  Xu, M ^a   Chen, Q R ^a   Kumar, D ^a   Stass, S A ^a   Mixson, A J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Gene therapy; Liposomes; Polymer; Systemic

Indexed keywords

LIPOSOME; POLYMER; PROTEIN P53;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0031684088     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.1998.2705     Document Type: Article

References (16)

1. Xu M, Kumar D, Stass S A, Mixson A J. Gene therapy with P53 and a fragment of thrombospondin I inhibits human breast cancerin vivo. Mol Genet Metab. 63:1998;103-109.
2. Xu M, Kumar D, Srinivas S, DeTolla L J, Yu S F, Stass S A, Mixson A J. Parenteral gene therapy with p53 inhibits human breast tumorsin vivo. Hum Gene Ther. 8:1997;177-185.
3. Lesoon-Wood L, Kim W H, Kleinman H K, Weintraub B D, Mixson A J. Systemic gene therapy with p53 reduces growth of a malignant human breast cancer in nude mice. Hum Gene Ther. 6:1995;395-405.
4. Hofland H, Huang L. Inhibition of human ovarian carcinoma cell proliferation by liposome-DNA complex. Biochem Biophys Res Commun. 207:1995;492-496.
5. Sakamoto N, Iwahana M, Tanaka N G, Osada Y. Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide. CDPGYIGSR-NH2. Cancer Res. 5:1991;903-906.
6. O'Reilly M S, Holmgren L, Shing Y, Chen C, Rosalind R A, Moses M, Snae W S, Cao Y, Sage E H, Folkman J. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:1994;315-328.
7. Maione T E, Gray G S, Petro J, Donner A J, Bauer S I, Carson H F, Sharpe R J. Inhibition of angiogenesis by recombinant human platelet 4 and related peptides. Science. 247:1990;77-79.
8. Clapp C, Martial J A, Gugman R C, Rentier-Delrue F, Weiner R I. The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis. Endocrinology. 133:1993;1292-1299.
9. Tolsma V S, Volpert O V, Good D J, Frazier W A, Polverini P J, Bouck N. Peptides derived form two separate domains of the matrix protein thrombospondin 1 have anti-angiogenic activity. J Cell Biol. 122:1993;497-511.
10. Zhu N, Liggit D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science. 261:1993;209-211.
11. Boussif O, Lezouac'H F, Zanta M A, Mergny M D, Scherman D, Demeneix B, Behr J-P. A versatile vector for gene and oligonucleotide transfer into cell in culture andin vivo: Proc Natl Acad Sci USA. 92:1995;7297-7301.
12. Haensler J, Szoka F C. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4:1993;372-379.
13. Ferrari, S, Moro, E, Pettenazzo, A, Behr, J, P, Zacchello, F, Scarpa, M, ExGen 500 is an efficient vector for gene delivery to lung epithelial cellsin vitroin vivo, Gene Ther, 4, 1100, 1106.
14. Folkman, J, Philadelphia, Lippincott, 1997, 3075, 3085.
15. Arap W, Pasqualini R L, Ruoslahti. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 279:1998;377-381.
16. Tanaka T, Manome Y, Wen P, Kufe D W, Fine H A. Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth. Nat Med. 3:1997;437-442.