Distinct role of adrenoceptor subtypes in cardiac adaptation to chronic pressure overload

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 3, 2008, Pages 355-360

  Du, Xiao Jun ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Adrenoceptor; Animal model; Cardiac hypertrophy; Fibrosis; Genetically modified mice; Heart failure; Pressure overload

Indexed keywords

ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; APOPTOSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE OVEREXPRESSION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE OVERLOAD; HEART VENTRICLE REMODELING; IN VIVO STUDY; INFLAMMATION; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BLOOD PRESSURE; HEART; HUMANS; RECEPTORS, ADRENERGIC;

EID: 39149112267     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04871.x     Document Type: Review

References (42)

1. Cohn JN, Levine TB, Olivari MT et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N. Engl. J. Med. 1984 311 : 819 23.
2. Kaye DM, Lefkovits J, Jennings GL et al. Adverse consequences of high sympathetic nervous activity in the failing human heart. J. Am. Coll. Cardiol. 1995 26 : 1257 63.
3. Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of β-adrenergic signaling in heart failure? Circ. Res. 2003 93 : 896 906.
4. Bristow MR. Mechanism of action of α-blocking agents in heart failure. Am. J. Cardiol. 1997 80 : L26 40.
5. Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev. 1999 51 : 651 90.
6. 3-adrenergic receptor. Cardiovasc. Res. 2003 59 : 288 96.
7. Francis GS, Chu C. Compensatory and maladaptive responses to cardiac dysfunction. Curr. Opin. Cardiol. 1994 9 : 280 8.
8. Simpson PC, Kariya K, Karns LR et al. Adrenergic hormones and control of cardiac myocyte growth. Mol. Cell. Biochem. 1991 104 : 35 43.
9. 1A-adrenergic- extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation 2007 115 : 763 72.
10. 2-adrenergic receptors. Trends Cardiovasc. Med. 2002 12 : 287 94.
11. Philipp M, Hein L. Adrenergic receptor knockout mice: Distinct functions of 9 receptor subtypes. Pharmacol. Ther. 2004 101 : 65 74.
12. Du XJ. Sympathoadrenergic mechanisms in functional regulation and development of cardiac hypertrophy and failure: Findings from genetically engineered mice. Cardiovasc. Res. 2001 50 : 443 53.
13. 1B-adrenergic receptor. Proc. Natl Acad. Sci. USA 1997 94 : 11 589 94.
14. 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc. Natl Acad. Sci. USA 2002 99 : 9474 9.
15. 1B-adrenergic receptor defect in mice. Circulation 2002 105 : 1700 7.
16. 1- Adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J. Clin. Invest. 2006 116 : 1005 15.
17. 1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J. Clin. Invest. 2003 111 : 1783 91.
18. 1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism. Cardiovasc. Res. 2005 65 : 436 45.
19. 1B-adrenergic receptors in the heart does not alleviate ischemic reperfusion injury. J. Mol. Cell. Cardiol. 2000 32 : 1679 86.
20. 1A-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy. Circ. Res. 2001 89 : 343 50.
21. 1A-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes. J. Mol. Cell. Cardiol. 2006 40 : 540 52.
22. 1A- adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc. Res. 2006 71 : 735 43.
23. 1B-adrenergic receptor induces dilated cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 2001 281 : H931 8.
24. 1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy. Am. J. Physiol. 1998 275 : H1338 50.
25. 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc. Natl Acad. Sci. USA 1994 91 : 10 109 13.
26. 1B-adrenergic receptors after pressure overload in mouse hearts. Am. J. Physiol. Heart Circ. Physiol. 2000 279 : H1079 86.
27. 1B-adrenergic receptor. J. Biol. Chem. 2001 276 : 13 738 43.
28. Du XJ, Fang L, Gao XM et al. Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction. J. Mol. Cell. Cardiol. 2004 37 : 979 87.
29. 1B-adrenergic receptors. J. Am. Coll. Cardiol. 2001 38 : 534 40.
30. αq overexpression induces cardiac contractile failure in mice. Proc. Natl Acad. Sci. USA 1997 94 : 8121 6.
31. αq-overexpressing mice. Circulation 1998 97 : 1488 95.
32. Rohrer DK. Physiological consequences of α-adrenergic receptor disruption. J. Mol. Med. 1998 76 : 764 72.
33. Kiriazis H, Wang K, Gao XM et al. Knockout of major β-adrenergic receptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis. Br. J. Pharmacol. 2008 (in press).
34. Esposito G, Rapacciuolo A, Naga Prasad SV et al. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 2002 105 : 85 92.
35. Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in α-adrenergic receptor transgenic mice. Proc. Natl Acad. Sci. USA 1999 96 : 7059 64.
36. 2-adrenergic receptors in the heart. Cardiovasc. Res. 2000 48 : 448 54.
37. 2-Adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis. Circulation 2000 101 : 71 7.
38. 2-Adrenergic receptor overexpression driven by α-MHC promoter is downregulated in hypertrophied and failing myocardium. Cardiovasc. Res. 2000 47 : 133 41.
39. 2-adrenoceptor overexpressing mice with and without pressure overload. Eur. J. Heart Fail 2003 5 : 131 6.
40. 1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. J. Biol. Chem. 1997 272 : 21 253 9.
41. 1-ARs in mouse heart: Coupling to differential PTX-sensitive pathways. J. Mol. Cell. Cardiol. 2005 39 : 777 84.
42. Kiriazis H, Sato Y, Kadambi VJ et al. Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis. Cardiovasc. Res. 2002 53 : 372 81.