Age-dependent cardiomyopathy and heart failure phenotype in mice overexpressing β2-adrenergic receptors in the heart

Cardiovascular Research

Volumn 48, Issue 3, 2000, Pages 448-454

  de Boer, Onno J ^a   van der Wal, Allard C ^a   Houtkamp, Mischa A ^a   Ossewaarde, Jacobus M ^b   Teeling, Peter ^a   Becker, Anton E ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Autonomic nervous system; Cardiomyopathy; Heart failure; Receptors; Ultrasound

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CARDIOMYOPATHY; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE; HEART VENTRICLE EXTRASYSTOLE; HISTOPATHOLOGY; MALE; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; WAVEFORM;

AGING; ANIMALS; CARDIOMYOPATHIES; CHI-SQUARE DISTRIBUTION; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FIBROSIS; HEART FAILURE, CONGESTIVE; MICE; MICE, TRANSGENIC; MYOCARDIUM; PHENOTYPE; PROSPECTIVE STUDIES; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0033710840     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00187-5     Document Type: Article

References (29)

1. Mechanism of action of beta-blocking agents in heart failure
2. β-Adrenergic receptor signaling: An acute compensatory adjustment - Inappropriate for the chronic stress of heart failure?
3. Increased β-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy
4. Cardiac function in mice overexpressing the β-adrenergci receptor kinase or a βARK inhibitor
5. 2-adrenergic receptor
6. 2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice
7. Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice
8. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy
9. 2+-stimulated adenylyl cyclase
10. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
11. ARK1 inhibition improves survival and cardiac function in a mouse model of severe cardiomyopathy
12. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
13. 1-adrenergic receptor transgenic mice
14. Adverse effects of chronic endogenous sympathetic drive induced by cardiac Gsα overexpression
15. β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse
16. 2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
17. Functional consequences of altering myocardial adrenergic receptor signaling
18. Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice
19. 2-Adrenergic receptor overexpression exacerbates development of heart failure following aortic stenosis
20. 2-adrenergic receptors
21. Transthoracic echocardiography in models of cardiac disease in the mouse
22. 2-adrenergic signal transduction
23. β-Adrenergic regulation of a myocardial actin gene via a cyclic AMP-independent pathway
24. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
25. Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy
26. Central role for ornithine decarboxylase in β-adrenoceptor mediated hypertrophy
27. Apoptosis of cardiac myocytes in Gsα transgenic mice
28. 2-adrenergic receptors on cardiac myocyte apoptosis
29. 2-adrenergic receptor and expression of a β-adrenergic receptor kinase-1 (βARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury