Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006)

Journal of the American Veterinary Medical Association

Volumn 232, Issue 3, 2008, Pages 411-417

  Levine, Jonathan M ^a   Levine, Gwendolyn J ^a   Boozer, Lindsay ^b   Schatzberg, Scott J ^b   Platt, Simon R ^b   Kent, Marc ^b   Kerwin, Sharon C ^a   Fosgate, Geoffrey T ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; GLUCOCORTICOID;

ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DOG DISEASE; FEMALE; HERNIA; INTERVERTEBRAL DISK; LUMBAR VERTEBRA; MALE; PATHOLOGY; POSTOPERATIVE COMPLICATION; RETROSPECTIVE STUDY; TREATMENT OUTCOME; VERTEBRA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; DOG DISEASES; DOGS; FEMALE; GLUCOCORTICOIDS; HERNIA; INTERVERTEBRAL DISK; LUMBAR VERTEBRAE; MALE; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; THORACIC VERTEBRAE; TREATMENT OUTCOME;

ANIMALIA; CANIS FAMILIARIS;

EID: 39149103717     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.232.3.411     Document Type: Article

References (52)

1. Hoerlein BF Canine neurology: diagnosis and treatment. Philadelphia: WB Saunders, 1978.
2. Dewey CW. Myelopathies: disorders of the spinal cord. In: Dewey CW, ed. A practical guide to canine and feline neurology. Ames, Iowa: Iowa State Press, 2003;277-336.
3. Coates JR. Intervertebral disk disease. Vet Clin North Am Small Anim Pract 2000;30:77-110.
4. Olby N. Current concepts in the management of acute spinal cord injury. J Vet Intern Med 1999;13:399-407.
5. Levine JM, Ruaux CG, Bergman RL, et al. Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease. AmJ Vet Res 2006;67:283-287.
6. McMichael MA, Ruaux CG, Baltzer WI, et al. Concentrations of 15F2t isoprostane in urine of dogs with intervertebral disk disease. Am J Vet Res 2006;67:1226-1231.
7. McDonald JW, Sadowsky C. Spinal-cord injury. Lancet 2002; 359:417-425.
8. Hurlbert RJ. Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg 2000;93:1-7.
9. Hall ED, Springer JE. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx 2004;1:80-100.
10. Hall ED. Lipid antioxidants in acute central nervous system injury. Ann Emerg Med 1993;22:1022-1027.
11. Hall ED. The neuroprotective pharmacology of methylprednisolone. J Neurosurg 1992;76:13-22.
12. Taoka Y, Okajima K, Uchiba M, et al. Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-alpha production. J Neurotrauma 2001;18:533-543.
13. Sharma A, Tiwari R, Badhe P, et al. Comparison of methylprednisolone with dexamethasone in treatment of acute spinal injury in rats. Indian J Exp Biol 2004;42:476-480.
14. Delattre JY, Arbit E, Rosenblum MK, et al. High dose versus low dose dexamethasone in experimental epidural spinal cord compression. Neurosurgery 1988;22:1005-1007.
15. Sasaki T, Sakuma J, Ichikawa T, et al. Effects of methylprednisolone on axonal depression induced by hypoxia, gammaaminobutyric acid, and (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide. Neurosurgery 2002;51:1477-1483.
16. Brandoli C, Shi B, Pflug B, et al. Dexamethasone reduces the expression of p75 neurotrophin receptor and apoptosis in contused spinal cord. Brain Res Mol Brain Res 2001;87:61-70.
17. Cherian L, Kuruvilla A, Chandy MJ, et al. Changes in phospholipids and acetylcholinesterase during early phase of injury to spinal cord-an experimental study in rats. Indian J Physiol Pharmacol 1996;40:134-138.
18. Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990;322:1405-1411.
19. Bracken MB, Shepard MJ, Collins WF Jr, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg 1992;76:23-31.
20. Bracken MB. Pharmacological treatment of acute spinal cord injury: current status and future projects. J Emerg Med 1993; 11(suppl 1):43-48.
21. Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997;277:1597-1604.
22. Saplosky RM. Glucocorticoids, stress and exacerbation of excitotoxic neuron death. Semin Neurosci 1994;6:323-331.
23. Braughler JM, Hall ED. Lactate and pyruvate metabolism in injured cat spinal cord before and after a single large intravenous dose of methylprednisolone. J Neurosurg 1983;59:256-261.
24. McCutcheon EP, Selassie AW, GuJK, et al. Acute traumatic spinal cord injury, 1993-2000. A population-based assessment of methylprednisolone administration and hospitalization. J Trauma 2004;56:1076-1083.
25. Pollard ME, Apple DF. Factors associated with improved neurologic outcomes in patients with incomplete teraplegia. Spine 2003;28:33-38.
26. Pointillart V, Petitjean ME, Wiart L, et al. Pharmacological therapy of spinal cord injury during the acute phase. Spinal Cord 2000;38:71-76.
27. Boag AK, Drobatz KJ. Complications of methylprednisolone sodium succinate in dachshunds with surgically treated intervertebral disc disease. J Vet Emerg Crit Care 2001;11:105-110.
28. Toombs JP, Caywood DD, Lipowitz AJ, et al. Colonic perforation following neurosurgical procedures and corticosteroid therapy in four dogs. J Am Vet Med Assoc 1980;177:68-72.
29. Moore RW, Withrow SJ. Gastrointestinal hemorrhage and pancreatitis associated with intervertebral disk diseases in the dog. J Am Vet Med Assoc 1982;180:1443-1447.
30. Culbert LA, Marino DJ, Baule RM, et al. Complications associated with high-dose prednisolone sodium succinate therapy in dogs with neurological injury. J Am Anim Hosp Assoc 1998;34:129-134.
31. Anderson DK, Saunders RD, Demediuk P, et al. Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Cent Nerv Syst Trauma 1985;2:257-267.
32. Levine JM, Levine GJ, Kerwin SC, et al. Association between various physical factors and acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds. J Am Vet Med Assoc 2006;229:370-375.
33. Frankel HL, Hancock DO, Hyslop G, et al. The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia. Paraplegia 1969;7: 179-192.
34. Kraus KH. Medical management of acute spinal cord disease. In: Bonagura JD, ed. Kirk's current veterinary therapy XIII. Philadelphia: WB Saunders Co, 1999; 186-190.
35. Plumb DC. Veterinary drug handbook. 4th ed. Ames, Iowa: Iowa State Press, 2002.
36. Wilcox KR. Conservative treatment of thoracolumbar intervertebral disc disease in the dog. J Am Vet Med Assoc 1965;147: 1458-1460.
37. Braughler JM. Lipid peroxidation-induced inhibition of gammaaminobutyric acid uptake in rat brain synaptosomes: protection by glucocorticoids. J Neurochem 1985;44:1282-1288.
38. Kuchner EF, Hansebout RR, Pappius HM. Effects of dexamethasone and of local hypothermia on early and late tissue electrolyte changes in experimental spinal cord injury. J Spinal Disord 2000;13:391-398.
39. De La Torre JC, Johnson CM, Goode DJ, et al. Pharmacologic treatment and evaluation of permanent experimental spinal cord trauma. Neurology 1975;25:508-514.
40. Hoerlein BF, Redding RW, Hoff EJ, et al. Evaluation of dexamethasone, DMSO, mannitol and solcosyl in acute spinal cord trauma. J Am Anim Hosp Assoc 1983;19:216-225.
41. Faden AI, Jacobs TP, Patrick DH, et al. Megadose corticosteroid therapy following experimental traumatic spinal injury. J Neurosurg 1984;60:712-717.
42. Rucker NC, Lumb WV, Scott RJ. Combined pharmacologic and surgical treatments for acute spinal cord trauma. Am J Vet Res 1981;42:1138-1142.
43. Gerndt SJ, Rodriguez JL, Pawlik JW, et al. Consequences of high-dose steroid therapy for acute spinal cord injury. J Trauma 1997;42:279-284.
44. Molano MD, Broton JG, Bean JA, et al. Complications associated with the prophylactic use of methylprednisolone during surgical stabilization after spinal cord injury. J Neurosurg 2002;96(suppl 3):S267-S272.
45. Matsumoto T, Tamaki T, Kawakami M, et al. Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury. Spine 2001;26:426-430.
46. Britt RC, Devine A, Swallen KC, et al. Corticosteroid use in the intensive care unit. At what cost? Arch Surg 2006;141:145-149.
47. Rohrer CR, Hill RC, Fischer A, et al. Efficacy of misoprostol in prevention of gastric hemorrhage in dogs treated with high doses of methylprednisolone sodium succinate. Am J Vet Res 1999;60:982-985.
48. Rohrer CR, Hill RC, Fischer A, et al. Gastric hemorrhage in dogs given high doses of methylprednisolone sodium succinate. Am J Vet Res 1999;60:977-981.
49. Torres SM, Diaz SF, Nogueira SA, et al. Frequency of urinary tract infection among dogs with pruritic disorders receiving long-term glucocorticoid treatment. J Am Vet Med Assoc 2005;227:239-243.
50. Stiffler KS, Stevenson MA, Sanchez S, et al. Prevalence and characterization of urinary tract infections in dogs with surgically treated type 1 thoracolumbar intervertebral disc extrusion. Vet Surg 2006;35:330-336.
51. Seguin MA, Vaden SL, Altier C, et al. Persistent urinary tract infections and reinfections in 100 dogs (1989-1999). J Vet Intern Med 2003;17:622-631.
52. Levine JM, Levine GJ, Johnson SI, et al. Evaluation of the success of medical management for presumptive thoracolumbar intervertebral disk herniation in dogs. Vet Surg 2007;36:482-491.