Changes in phospholipids and acetylcholinesterase during early phase of injury to spinal cord - An experimental study in rats

Indian Journal of Physiology and Pharmacology

Volumn 40, Issue 2, 1996, Pages 134-138

  Cherian, L ^a   Kuruvilla, A ^a   Chandy, M J ^a   Abraham, J ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

acetylcholinesterase; dexamethasone; phospholipids; spinal injury; verapamil

Indexed keywords

ACETYLCHOLINESTERASE; DEXAMETHASONE; PHOSPHOLIPID; VERAPAMIL;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; NONHUMAN; RAT; SPINAL CORD INJURY;

ACETYLCHOLINESTERASE; ANEURYSM; ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCIUM; CALCIUM CHANNEL BLOCKERS; DEXAMETHASONE; EXTRACELLULAR SPACE; FEMALE; MALE; PHOSPHOLIPIDS; RATS; RATS, WISTAR; SPINAL CORD INJURIES; VERAPAMIL;

EID: 0029887932     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Bingham WG, Goldman H, Friedman SJ et al. Blood flow in normal and injured monkey spinal cord. Journal of Neurosurgery 1975; 43 : 162-171.
2. Senter HJ, Venes JL. Altered blood flow and secondary injury in experimental spinal cord trauma. Journal of Neurosurgery 1978; 49 : 569-578.
3. Feldman RA, Yashon D, Locke GE, Hunt WE. Lactate accumulation in primate spinal cord daring circulatory arrest. Journal of Neurosurgery 1971; 34 : 618.
4. Osterholm JL, Mathews GJ. A proposed biochemical mechanism for traumatic spinal cord hemorrhagic necrosis. Successful therapy for severe injuries by metabolic blockade. Trans American Neurological Association 1971; 96 : 187-191.
5. Demopoulos HB, Flamm ES, Pietronigro DD, Seligmann ML. The free radical pathology and the microvasculation in the major central nervous system disorders. Acta Physiologia Scandinavia (suppl) 1980; 492 : 91-119.
6. Anderson DK, Means ED. Iron induced lipid peroxidation in spinal cord, protection with mannitol and methyl prednisolone. Journal of Free Radicals Biology and Medicine 1982; 1 : 59-64.
7. Pryor WA, Stanley JP, Blair E. Auto oxidation of polyunsaturated fatty acids : II. A suggested mechanism for the formation of TBA - reactive material from prostaglandin like endoperoxides. Lipids 1976; 11 : 370-379.
8. Delattre JY, Arbit E, Thaler HT, Rosenblum MK, Posner JB. A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor. Journal of Neurosurgery 1989; 70 : 920-925.
9. Eidelberg EM, Staten E, Watkings AC, McGraw D, McFadden C A model of spinal cord injury. Surgical Neurology 1976; 6 : 35-38.
10. Rivlin AS, Tatar CH. Regional spinal cord blood flow in rats after severe cord trauma. Journal of Neurosurgery 1978; 49 : 844-853.
11. Rivlin AS, Tatar CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. Journal of Neurosurgery 1977; 47 : 577-581.
12. Ellman GL, Courtney KD, Andres V Jr, Featherstone K. A new and rapid calorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7 : 75-88.
13. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1957; 193 : 265-275.
14. Falch, Less M. Stanley CHS. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 1957: 226 : 497-509.
15. Bartlett RG. Phosphorous assay in column chromatography. Journal of Biological Chemistry 1959; 234 : 466-468.
16. Allan D, Thomas P, Michell RH. Rapid transbilayer diffusion of 1,2-dicyl glyceral and its relevance to control of membrance curvature. Nature (London) 1978; 276 : 286-290.
17. Johnson HT Jr, Daniel HB. Altered levels of PGF in cat spinal cord tissue following traumatic injury. Prostaglandins 1976; 11 : 51-61.
18. Cherian L, Kuruvilla A, Abraham J. Changes in acetylcholinesterase during early phase of experimental spinal cord trauma in primates. Indian Journal of Experimental Biology 1989; 27 : 751-753.
19. Weidenfeld J, Sysy J, Shohami E. The effect of dexamethasone on prostaglandin synthesis in various brain areas of the rat. Journal of Neurochemistry 1987; 48 : 1351-1354.
20. Demopoulos HB. Flamm ES, Seligman ML, Pietrocigro DD, Tomasula J. DeCricito V. Further studies or free radical pathology in the major central nervous system disorders : Effect of very high doses of methyl prednisolone in the functional outcome, morphology and chemistry of experimental spinal cord impact injury. Canadian Journal of Physiology and Pharmacology 1982; 60 : 1415-1424.
21. Kurihara M. Role of monoamines in experimental spinal cord injury in rats. Relationship between Na+K+ATPase and lipid peroxidation. Journal of Neurosurgery 1985; 62 : 743-749.
22. Young W, Flamm ES. Effect of high dose of corticosteroid therapy on blood flow, evoked potentials and extra cellular calcium in experimental spinal injury. Journal of Neurosurgery 1982; 57 : 667-673.
23. Braughler JM, Hall ED. Effects of multidose methyl prednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism. Journal of Neurosurgery 1984; 61 : 290-295.
24. Schanne Fax, Kane AB, Young EE, Farber JL. Calcium dependence of toxic cell death : a final common pathway. Science 1979; 206 : 700-702.
25. Deshpande JK, Siesjo BK,. Wieloch T. Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischaemia. Journal of Cerebral Blood Flow and Metabolism 1978; 7 : 89-95.