Complications of methylprednisolone sodium succinate therapy in dachshunds with surgically treated intervertebral disc disease

Journal of Veterinary Emergency and Critical Care

Volumn 11, Issue 2, 2001, Pages 105-110

  Boag, Amanda K ^a,b   Otto, Cynthia M ^a   Drobatz, Kenneth J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Corticosteroid; Decompressive surgery; Melena; Spinal trauma

Indexed keywords

EID: 0141823557     PISSN: 14793261     EISSN: 14764431     Source Type: Journal    
DOI: 10.1111/j.1476-4431.2001.tb00076.x     Document Type: Article

References (34)

1. Olby N. Current concepts in the management of acute spinal cord injury. J Vet Intern Med 1999;13:399–407.
2. LeCouteur RA, Child G. Diseases of the spinal cord. In: Ettinger SJ, Feldman EC, editors. Textbook of Veterinary Internal Medicine. Philadelphia :W. B. Saunders Co; 1995. p. 629–696.
3. Means ED, Anderson DK, Waters TR, Kalaf L. Effect of methylprednisolone in compression trauma to the feline spinal cord. J Neurosurg 1981;55:200–208.
4. Braughler JM, Hall ED. Lactate and pyruvate metabolism in injured cat spinal cord before and after a single large intravenous dose of methylprednisolone. J Neurosurg 1983;59:256–261.
5. Braughler JM, Hall ED. Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism. J Neurosurg 1984;61:290–295.
6. Braughler JM, Hall ED, Means ED, Waters TR, Anderson DK. Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury. J Neurosurg 1987;67:102–105.
7. Behrmann DL, Bresnahan JC, Beattie MS. Modelling of acute spinal cord injury in the rat Neuroprotection and enhanced recovery with methylprednisolone, U-74006Fand YM-14673. Exp Neurol 1994;126:61–75.
8. Constantini S, Young W. The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 1994;80:97–111.
9. Hall ED, Yonkers PA, Taylor BM, Sun FF. Lack of effect of post injury treatment with methylprednisolone or tirilazad mesylate on the increase in eicosanoid levels in the acutely injured cat spinal cord. J Neurotrauma 1995;2:245–256.
10. + )- ATP-ase, lipid peroxidation, and alpha motor neuron function. J Neurosurg 1982;56:838–84.
11. Braughler JM, Hall ED. Current application of “high-dose” steroid therapy for CNS injury. J Neurosurg 1985;62:806–810.
12. Brown SA, Hall ED. Role of oxygen-derived free radicals in the pathogenesis of shock and trauma, with focus on central nervous system injuries. J Am Vet Med Assoc 1992;200: 1849–1858.
13. Hall ED. The neuroprotective pharmacology of methylprednisolone. J Neurosurg 1992;76:13–22.
14. Bracken MB, Shepard MJ, Collins WF, et al. A randomized controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N Engl J Med 1990;322(20):1405–1411.
15. Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. J Am Med Assoc 1997;277(20):1597–1604.
16. Galandiuk S, Raque G, Appel S, Polk HC. The two-edged sword of large dose steroids for spinal cord trauma. Ann Surg 1993;218(4):419–427.
17. Gerndt SJ, Rodriguez JL, Pawlik JW, et al. Consequences of highdose steroid therapy for acute spinal cord injury. J Trauma: Injury Infect Crit Care 1997;42(2):279–282.
18. Coates JR, Sorjonen DC, Simpson ST, et al. Clinicopathologic effects of a 21-aminosteroid compound (U74389G) and high-dose methylprednisolone on spinal cord function after simulated spinal cord trauma. Vet Surg 1995;24:128–139.
19. Siemering GB, Vroman ML. High dose methylprednisolone sodium succinate: an adjunct to surgery for canine intervertebral disc herniation. Vet Surg 21:406 (abstract) 1992.
20. Kewalramani LS. Neurogenic gastro-duodenal ulceration and bleeding associated with spinal cord injuries. J Trauma 1979;19(4):259–265.
21. Rohrer CR, Hill RC, Fischer A, et al. Gastric hemorrhage in dogs give high doses of methylpredisolone sodium succinate. Am J Vet Res 1999;60(8):977–981.
22. Rohrer CR, Hill RC, Fischer A, et al. Efficacy of misoprostol in prevention of gastric hemorrhage in dogs treated with high doses of methylprednisolone sodium succinate. Am J Vet Res 1990;60(8):982–985.
23. Hanson SM, Bostwick DR, Twedt DC, Smith MO. Clinical evaluation of cimetidine, sucralfate and misoprostol for prevention of gastro-intestinal tract bleeding in dogs undergoing spinal surgery. Am J Vet Res 1997;58(11):1320–1323.
24. Funkquist B. Decompressive laminectomy in thoracolumbar disc protrusion with paraplegia in the dog. J Small Anim Pract 1970;11:445–451.
25. Bracken MB, Freeman DH, Hellenbrand K. Incidence of acute traumatic hospitalised spinal cord injury in the United States,1970-1977. Am J Epidemiol 1981;113(6):615–622.
26. Bracken MB, Shepard MJ, Collins WF, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. J Neurosurg 1992;76:23–31.
27. Bracken MB, Holford TR. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J Neurosung 1993;79:500–507.
28. Ducker TB, Zeidman SM. Spinal cord injury: Role of steroid therapy. Spine 1994; 19(20):2281–2287.
29. Toombs JP, Caywood DD, Lipowitz AL, Stevens JB. Colonic perforation following neurosurgical procedures and corticosteroid therapy in four dogs. J Am Vet Med Assoc 1980;177(1):68–72.
30. Moore RW, Withrow SJ. Gastro-intestinal hemorrhage and pancreatitis associated with intervertebral disc disease in the dog. J Am Vet Med Assoc 1982;180(12):1443–1447.
31. Sorjonen DC, Dillon AR, Powers RD, Spano JS. Effects of dexamethasone and surgical hypotension on the stomach of dogs: Clinical, endoscopic and pathologic evaluations. Am J Vet Res 1983;44(7):1233–1237.
32. Toombs JP, Collins LG, Graves GM, Crowe DT, Caywood DD. Colonic perforation in corticosteroid-treated dogs. J Am Vet Med Assoc 1986;188(2):145–150.
33. Neiger R, Gaschen F Jaggy A. Gastric muscosal lesions in dogs with acute intervertebral disc disease: characterization and effects of omeprazole and misoprotol. J Vet Intern Med 2000; 14:33–36.
34. McDonald JM Glucocorticoid therapy. In: Ettinger SJ, Feldman EC, editors. Textbook of Veterinary Internal Medicine. Philadelphia :W. B. Saunders Co; 2000. p. 307–317.