Outcome-based profiling of astrocytic tumours identifies prognostic gene expression signatures which link molecular and morphology-based pathology

International Journal of Oncology

Volumn 29, Issue 5, 2006, Pages 1183-1191

  Beetz, Christian ^a   Bergner, Sven ^a   Brodoehl, Stefan ^a   Brodhun, Michael ^a   Ewald, Christian ^a   Kalff, Rolf ^a   Krüger, Jutta ^b   Patt, Stephan ^a   Kiehntopf, Michael ^a   Deufel, Thomas ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b HELIOS KLINIKUM ERFURT   (Germany)

Author keywords

Astrocytoma; Expression profiling; Outcome; Prognosis

Indexed keywords

RNA; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTROCYTOMA; BRAIN TUMOR; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MALE; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GENE;

ADOLESCENT; ADULT; AGED; ASTROCYTOMA; BRAIN NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENES, NEOPLASM; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TUMOR MARKERS, BIOLOGICAL;

EID: 39049190229     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.29.5.1183     Document Type: Article

References (44)

1. Kleihues P and Cavanee WK: Pathology and Genetics - Tumours of the Central Nervous System. IARC Press, Lyon, 2000.
2. Collins VP: Gliomas. Cancer Surv 32: 37-51, 1998.
3. Kernohan JW, Mabon RF, Svien HJ and Adson AW: A simplified classification of gliomas. Proc Staff Meet Mayo Clin 24: 71-75, 1949.
4. Daumas-Duport C, Scheithauer B, O'Fallon J and Kelly P: Grading of astrocytomas. A simple and reproducible method. Cancer 62: 2152-2165, 1988.
5. Coons SW, Johnson PC, Scheithauer BW, Yates AJ and Pearl DK: Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas. Cancer 79: 1381-1393, 1997.
6. Louis DN, Holland EC and Cairncross JG: Glioma classification: a molecular reappraisal. Am J Pathol 159: 779-786, 2001.
7. Ueki K, Nishikawa R, Nakazato Y, et al: Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, tp53, egfr, cdk4, and cdkn2a in 91 astrocytic and oligodendroglial tumors. Clin Cancer Res 8: 196-201, 2002.
8. Caskey LS, Fuller GN, Bruner JM, Yung WK, Sawaya RE, Holland EC and Zhang W: Toward a molecular classification of the gliomas: histopathology, molecular genetics, and gene expression profiling. Histol Histopathol 15: 971-981, 2000.
9. Cairncross JG, Ueki K, Zlatescu MC, et al: Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90: 1473-1479, 1998.
10. Huang H, Colella S, Kurrer M, Yonekawa Y, Kleihues P and Ohgaki H: Gene expression profiling of low-grade diffuse astrocytomas by cdna arrays. Cancer Res 60: 6868-6874, 2000.
11. Markert JM, Fuller CM, Gillespie GY, et al: Differential gene expression profiling in human brain tumors. Physiol Genomics 5: 21-33, 2001.
12. Madden SL, Cook BP, Nacht M, et al: Vascular gene expression in non-neoplastic and malignant brain. Am J Pathol 165: 601-608, 2004. (Pubitemid 38971389)
13. Kim S, Dougherty ER, Shmulevich L, et al: Identification of combination gene sets for glioma classification. Mol Cancer Ther 1: 1229-1236, 2002.
14. Shai R, Shi T, Kremen TJ, et al: Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 22: 4918-4923, 2003. (Pubitemid 36981282)
15. Huang H, Okamoto Y, Yokoo H, et al: Gene expression profiling and subgroup identification of oligodendrogliomas. Oncogene 23: 6012-6022, 2004.
16. Fuller GN, Rhee CH, Hess KR, et al: Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: A revelation by parallel gene expression profiling. Cancer Res 59: 4228-4232, 1999.
17. Sallinen SL, Sallinen PK, Haapasalo HK, et al: Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res 60: 6617-6622, 2000.
18. Rickman DS, Bobek MP, Misek DE, et al: Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis. Cancer Res 61: 6885-6891, 2001.
19. Watson MA, Perry A, Budhjara V, Hicks C, Shannon WD and Rich KM: Gene expression profiling with oligonucleotide microarrays distinguishes world health organization grade of oligodendrogliomas. Cancer Res 61: 1825-1829, 2001.
20. Hunter S, Young A, Olson J, et al: Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein d as a marker for low-grade, non-infiltrating primary cns neoplasms. J Neuropathol Exp Neurol 61: 275-281, 2002.
21. Tanwar MK, Gilbert MR and Holland EC: Gene expression microarray analysis reveals ykl-40 to be a potential serum marker for malignant character in human glioma. Cancer Res 62: 4364-4368, 2002.
22. Godard S, Getz G, Delorenzi M, et al: Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res 63: 6613-6625, 2003.
23. Khatua S, Peterson KM, Brown KM, et al: Overexpression of the egfr/fkbp12/hif-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res 63: 1865-1870, 2003.
24. Gutmann DH, Hedrick NM, Li J, Nagarajan R, Perry A and Watson MA: Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas. Cancer Res 62: 2085-2091, 2002.
25. Mukasa A, Ueki K, Matsumoto S, et al: Distinction in gene expression profiles of oligodendrogliomas with and without allelic loss of 1p. Oncogene 21: 3961-3968, 2002.
26. Mischel PS, Shai R, Shi T, et al: Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene 22: 2361-2373, 2003. (Pubitemid 36566791)
27. Raza SM, Fuller GN, Rhee CH, Huang S, Hess K, Zhang W and Sawaya R: Identification of necrosis-associated genes in glioblastoma by cdna microarray analysis. Clin Cancer Res 10: 212-221, 2004.
28. Van den Boom J, Wolter M, Kuick R, et al: Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol 163: 1033-1043, 2003.
29. Nutt CL, Mani DR, Betensky RA, et al: Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res 63: 1602-1607, 2003.
30. Freije WA, Castro-Vargas FE, Fang Z, et al: Gene expression profiling of gliomas strongly predicts survival. Cancer Res 64: 6503-6510, 2004.
31. Rich JN, Hans C, Jones B, et al: Gene expression profiling and genetic markers in glioblastoma survival. Cancer Res 65: 4051-4058, 2005.
32. Dong S, Nutt CL, Betensky RA, et al: Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol 64: 948-955, 2005.
33. Liang Y, Diehn M, Watson N, et al: Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci USA 102: 5814-5819, 2005.
34. Simon R: Using DNA microarrays for diagnostic and prognostic prediction. Expert Rev Mol Diagn 3: 587-595, 2003.
35. Eszlinger M, Krohn K, Frenzel R, Kropf S, Tonjes A and Paschke R: Gene expression analysis reveals evidence for inactivation of the TGF-beta signaling cascade in autonomously functioning thyroid nodules. Oncogene 23: 795-804, 2004.
36. Eisen MB, Spellman PT, Brown PO and Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868, 1998.
37. Kaplan E and Meier P: Non-parametric estimation from incomplete observations. J Am Statist Assoc 53: 457-481, 1958.
38. Frahm C, Haupt C, Weinandy F, Siegel G, Bruehl C and Witte OW: Regulation of gaba transporter mrna and protein after photothrombotic infarct in rat brain. J Comp Neurol 478: 176-188, 2004.
39. Iwadate Y, Sakaida T, Hiwasa T, Nagai Y, Ishikura H, Takiguchi M and Yamaura A: Molecular classification and survival prediction in human gliomas based on proteome analysis. Cancer Res 64: 2496-2501, 2004.
40. Zukiel R, Nowak S, Barciszewska AM, Gawronska I, Keith G and Barciszewska MZ: A simple epigenetic method for the diagnosis and classification of brain tumors. Mol Cancer Res 2: 196-202, 2004. (Pubitemid 39030309)
41. Kim AS: Clinical impact of gene expression profiling on oncology diagnosis, prognosis, and treatment. Comb Chem High Throughput Screen 7: 183-206, 2004.
42. Oehring RD, Miletic M, Valter MM, Pietsch T, Neumann J, Fimmers R and Schlegel U: Vascular endothelial growth factor (vegf) in astrocytic gliomas - a prognostic factor? J Neurooncol 45: 117-125, 1999.
43. Leins A, Riva P, Lindstedt R, Davidoff MS, Mehraein P and Weis S: Expression of tenascin-c in various human brain tumors and its relevance for survival in patients with astrocytoma. Cancer 98: 2430-2439, 2003. (Pubitemid 37466658)
44. Rempel SA, Golembieski WA, Ge S, Lemke N, Elisevich K, Mikkelsen T and Gutierrez JA: Sparc: a signal of astrocytic neoplastic transformation and reactive response in human primary and xenograft gliomas. J Neuropathol Exp Neurol 57: 1112-1121, 1998. (Pubitemid 28562739)