Diverse Structures of Chimeric CYP-REP7/6-Containing CYP2D6 and a Novel Defective CYP2D6 Haplotype Harboring Single-type 36 and CYP-REP7/6 in Japanese

Drug Metabolism and Pharmacokinetics

Volumn 21, Issue 5, 2006, Pages 395-405

  Soyama, Akiko ^a   Saito, Yoshiro ^a,b   Ozawa, Shogo ^a,d   Ohno, Yasuo ^c,d   Komamura, Kazuo ^e,f   Kamakura, Shiro ^e   Kitakaze, Masafumi ^e   Tomoike, Hitonobu ^e  

^a Project Team for Pharmacogenetics   (Japan)

^b Division of Biochemistry and Immunochemistry   (Japan)

^c Division of Pharmacology   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e Department of Cardiology ^*  (Japan)

^f NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

CYP REP diversity; CYP2D6*10D; REP7 6 with CYP2D6; single type CYP2D6*36; tandemtype *36 *10D

Indexed keywords

CYTOCHROME P450 2D6; DNA;

ARTICLE; ASIAN; CHEMISTRY; DNA SEQUENCE; GENE DELETION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; JAPAN; MOLECULAR GENETICS; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CYTOCHROME P-450 CYP2D6; DNA; GENE DELETION; GENE FREQUENCY; GENETICS, POPULATION; GENOTYPE; HAPLOTYPES; HUMANS; JAPAN; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

EID: 39049185956     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.21.395     Document Type: Article

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