Ca2+/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation

Archives of Dermatological Research

Volumn 294, Issue 4, 2002, Pages 198-202

  Praskova, M ^a   Kalenderova, S ^a   Miteva, L ^a   Poumay, Y ^b   Mitev, V ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b UNIVERSITY OF NAMUR   (Belgium)

Author keywords

c Myc; CaM kinase; Keratinocytes; MAPK; Proliferation

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALCINEURIN; CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; WORTMANNIN; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DRUG DERIVATIVE; ENZYME INHIBITOR; FLAVONOID; MYC PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN);

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; ONCOGENE C MYC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL DIVISION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELLS, CULTURED; ENZYME INHIBITORS; FLAVONES; HUMAN; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; FLAVONOIDS; HUMANS;

EID: 0036019586     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-002-0312-4     Document Type: Article

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