Epigenetic and genetic alterations of the EDNRB gene in nasopharyngeal carcinoma

Oncology

Volumn 72, Issue 5-6, 2008, Pages 357-363

  Zhou, Liang ^a,c   Feng, Xiangling ^a   Shan, Wenjiao ^a   Zhou, Wen ^a   Liu, Weidong ^a   Wang, Lei ^a   Zhu, Bin ^a   Yi, Hongmei ^a,b   Yao, Kaitai ^a,d   Ren, Caiping ^a  

^a Central South University   (China)

^b Hunan Province People's Hospital   (China)

^c PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

EDNRB expression; Hypermethylation; Loss of heterozygosity; Nasopharyngeal carcinoma

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ENDOTHELIN B RECEPTOR; MESSENGER RNA;

ADULT; ARTICLE; CANCER CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; MALE; METHYLATION; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; CELL LINE, TUMOR; CHRONIC DISEASE; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; MALE; METHYLATION; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PHARYNGITIS; RECEPTOR, ENDOTHELIN B; RHINITIS;

EID: 39049103241     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000113146     Document Type: Article

References (32)

1. Huang Z, Desper R, Yao K, Yin Z, Li X, Yao K: Construction of tree models for pathogenesis of nasopharyngeal carcinoma. Genes Chromosomes Cancer 2004;40:307-315.
2. Zhou L, Jiang WH, Ren C, Feng X, Liu W, Tao Q, Yao K: Frequent hypermethylation of RASSF1A and TSLC1, and high viral load of Epstein-Barr virus DNA in nasopharyngeal carcinoma and matched tumor-adjacent tissues. Neoplasia 2005;7:809-815.
3. Yi H, Li H, Peng D, Zhang H, Wang L, Zhao M, Yao K, Ren C: Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma. Oncol Res 2006;16:261-272.
4. Shin MK, Levorse JM, Ingram RS, Tilghman S: The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 1999;402:496-501.
5. Ford HL: Homeobox genes: a link between development, cell cycle, and cancer? Cell Biol Int 1998;22:397-400.
6. Puffenberger EG, Hosoda K, Washington SS, Nakao K, deWit D, Yanagisawa M, Chakravart A: A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 1994;79:1257-1266.
7. Jackson IJ: Homologous pigmentation mutations in human, mouse and other model organisms. Hum Mol Genet 1997;6:1613-1624.
8. Chen SC, Lin CY, Chen YH, Fang HY, Cheng CY, Chang CW, Chen RA, Tai HL, Lee CH, Chou MC, Lin TS, Hsu LS: Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. Oncol Rep 2006;15:167-172.
9. Hsu LS, Lee HC, Chau GY, Yin PH, Chi CW, Lui WY: Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. Oncol Rep 2006;15:507-511.
10. Pao MM, Tsutsumi M, Liang G, Uzvolgyi E, Gonzales FA, Jones PA: The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells. Hum Mol Genet 2001;10:903-910.
11. Lo KW, Tsang YS, Kwong J, To KF, Teo PM, Huang DP: Promoter hypermethylation of the EDNRB gene in nasopharyngeal carcinoma. Int J Cancer 2002;98:651-655.
12. Peng D, Ren C, Yi H, Zhou L, Yang X, Li H, Yao K: Genetic and epigenetic alterations of DLC-1, a candidate tumor suppressor gene, in nasopharyngeal carcinoma. Acta Biochim Biophys Sin 2006;38:349-355.
13. Clark SJ, Harrison J, Paul CL, Frommer M: High sensitivity mapping of methylated cytosines. Nucleic Acids Res 1994;22:2990-2997.
14. Qiu GH, Tan LK, Loh KS, Lim CY, Srivastava G, Tsai ST, Tsao SW, Tao Q: The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Oncogene 2004;23:4793-4806.
15. Jerónimo C, Henrique R, Campos PF, Oliveira J, Caballero OL, Lopes C, Sidransky D: Endothelin B receptor gene hypermethylation in prostate adenocarcinoma. J Clin Pathol 2003;56:52-55.
16. Tsutsumi M, Liang G, Jones PA: Novel endothelin B receptor transcripts with the potential of generating a new receptor. Gene 1999;228:43-49.
17. Chen YJ, Ko JY, Chen PJ, Shu CH, Hsu MT, Tsai SF, Lin CH: Chromosomal aberrations in nasopharyngeal carcinoma analyzed by comparative genomic hybridization. Genes Chromosomes Cancer 1999;25:169-175.
18. Hui AB, Lo KW, Leung SF, Teo P, Fung MK, To KF, Wong N, Choi PH, Lee JC, Huang DP: Detection of recurrent chromosomal gains and losses in primary nasopharyngeal carcinoma by comparative genomic hybridisation. Int J Cancer 1999;82:498-503.
19. Fang Y, Guan X, Guo Y, Sham J, Deng M, Liang Q, Li H, Zhang H, Zhou H, Trent J: Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization. Genes Chromosomes Cancer 2001;30:254-260.
20. Lo KW, Huang DP: Genetic and epigenetic changes in nasopharyngeal carcinoma. Semin Cancer Biol 2002;12:451-462.
21. Pla P, Larue L: Involvement of endothelin receptors in normal and pathological development of neural crest cells. Int J Dev Biol 2003; 47:315-325.
22. Liu XQ, Chen HK, Zhang XS, Pan ZG, Li A, Feng QS, Long QX, Wang XZ, Zeng YX: Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma. Int J Cancer 2003;106:60-65.
23. Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW: Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes Chromosomes Cancer 2007;46:171-180.
24. Kwong J, Lo KW, Chow LS, Chan FL, To KF, Huang DP: Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. Int J Cancer 2005;113:386-392.
25. Ying J, Li H, Seng TJ, Langford C, Srivastava G, Tsao SW, Putti T, Murray P, Chan AT, Tao Q: Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene 2006;25:1070-1080.
26. Ying J, Srivastava G, Hsieh WS, Gao Z, Murray P, Liao SK, Ambinder R, Tao Q: The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clin Cancer Res 2005;11:6442-6449.
27. Cheung HW, Ching YP, Nicholls JM, Ling MT, Wong YC, Hui N, Cheung A, Tsao SW, Wang Q, Yeun PW, Lo KW, Jin DY, Wang X: Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation. Mol Carcinog 2005;43:237-245.
28. Nelson JB, Lee WH, Nguyen SH, Jarrard DF, Brooks JD, Magnuson SR, Opgenorth TJ, Nelson WG, Bova GS : Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer. Cancer Res 1997;57:35-37.
29. Kwabi-Addo B, Chung W, Shen L, Ittmann M, Wheeler T, Jelinek J, Issa JP: Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res 2007;13:3796-3802.
30. Olasz J, Juhasz A, Remenar E, Engi H, Bak M, Csuka O, Kasler M: RAR beta2 suppression in head and neck squamous cell carcinoma correlates with site, histology and age. Oncol Rep 2007;18:105-112.
31. Marsit CJ, Houseman EA, Schned AR, Karagas MR, Kelsey KT: Promoter hypermethylation is associated with current smoking, age, gender, and survival in bladder cancer. Carcinogenesis 2007;28:1745-1751.
32. Friedrich MG, Weisenberger DJ, Cheng JC: Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clin Cancer Res 2004;10:7457-7465.