Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor

Nature Biotechnology

Volumn 26, Issue 2, 2008, Pages 209-211

  Kai, Masayuki ^a   Motoki, Kazuhiro ^a   Yoshida, Hideaki ^a   Emuta, Chie ^a   Chisaka, Yukiko ^a   Tsuruhata, Kumi ^a   Endo, Chisato ^a   Muto, Mari ^a   Shimabe, Munetake ^a   Nishiyama, Uichi ^a   Hagiwara, Tetsuya ^a   Matsumoto, Atsushi ^a   Miyazaki, Hiroshi ^a   Kataoka, Shiro ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; PHARMACOKINETICS; SWITCHING FUNCTIONS;

AGONIST ACTIVITY; HINGE REGIONS; SWITCHING CONSTANTS; THROMBOCYTOPENIA; THROMBOPOIETIN RECEPTORS;

ANTIBODIES;

ANTIBODY; IMMUNOGLOBULIN G; THROMBOPOIETIN RECEPTOR;

ARTICLE; BONE MARROW CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ANTIBODIES, MONOCLONAL; GENETIC ENHANCEMENT; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THROMBOPOIETIN; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38949193925     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1376     Document Type: Article

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