Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid

Biochemical Pharmacology

Volumn 53, Issue 8, 1997, Pages 1077-1086

  Thams, Peter ^a   Capito, Kirsten ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

ACA; arachidonic acid; insulin secretion; K+ permeability; mouse pancreatic islets; RHC 80267

Indexed keywords

1,6 HEXAMETHYLENEDICARBAMIC ACID BIS(CYCLOHEXANONE OXIME) ESTER; 6 [2 [4 [(4 FLUOROPHENYL)PHENYLMETHYLENE] 1 PIPERIDYL]ETHYL] 7 METHYL 5H THIAZOLO[3,2 A]PYRIMIDIN 5 ONE; ARACHIDONIC ACID; CALCIUM ION; CINNAMYL ANTHRANILATE; DIACYLGLYCEROL; DIAZOXIDE; ENZYME INHIBITOR; GLUCOSE; INDOMETACIN; INSULIN; LIPOPROTEIN LIPASE; NORDIHYDROGUAIARETIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDIC ACID; PHOSPHOLIPASE A2 INHIBITOR; POTASSIUM CHANNEL; POTASSIUM ION; RUBIDIUM 86;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG MECHANISM; GLUCOSE METABOLISM; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; POTASSIUM TRANSPORT; PRIORITY JOURNAL;

ANIMALS; ANTHRANILIC ACIDS; ARACHIDONIC ACID; CINNAMATES; CYCLOHEXANONES; DIAZOXIDE; ENZYME INHIBITORS; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; LIPOPROTEIN LIPASE; MALE; MICE; PHOSPHOLIPASES A; POTASSIUM CHANNELS; RUBIDIUM RADIOISOTOPES;

EID: 0030920806     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00813-1     Document Type: Article

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