Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children

Pediatrics

Volumn 118, Issue 2, 2006, Pages 820-824

  Lam, Hugh Simon ^a   Chung, Mo Chow ^a   Wing, Tat Poon ^b   Chi, Kong Lai ^b   Chan, Kwan Chee Allen ^a   Wai, Lan Yeung ^a   Hui, Joannie ^a   Chan, Albert Yan Wo ^b   Pak, Cheung Ng ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b PRINCESS MARGARET HOSPITAL   (Hong Kong)

Author keywords

Acute vitamin A overdose; Vitamin A kinetics; Vitamin supplementation

Indexed keywords

RETINOL; RETINOL PALMITATE; VITAMIN D; DRUG DERIVATIVE; ERGOCALCIFEROL; SUGAR;

ARTICLE; CASE REPORT; CHEWABLE TABLET; DRUG OVERDOSE; HUMAN; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RETINOL INTOXICATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BIOTRANSFORMATION; BLOOD; DIET SUPPLEMENTATION; FOLLOW UP; HONG KONG; INTOXICATION; RISK; TABLET;

BIOTRANSFORMATION; CANDY; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; ERGOCALCIFEROLS; FOLLOW-UP STUDIES; HONG KONG; HUMANS; HYPERVITAMINOSIS A; MALE; OVERDOSE; RISK; TABLETS; VITAMIN A;

EID: 33748439004     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2006-0167     Document Type: Article

References (20)

1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press; 2001
2. Fishman RA. Polar bear liver, vitamin A, aquaporins, and pseudotumor cerebri. Ann Neurol. 2002;52:531-533
3. Allen LH, Haskell M. Estimating the potential for vitamin A toxicity in women and young children. J Nutr. 2002;132(9 suppl):2907S-2919S
4. Kowalski TE, Falestiny M, Furth E, Malet PF. Vitamin A hepatotoxicity: a cautionary note regarding 25,000 IU supplements. Am J Med. 1994;97:523-528
5. Bush ME, Dahms BB. Fatal hypervitaminosis A in a neonate. Arch Pathol Lab Med. 1984;108:838-842
6. Ross DA. Recommendations for vitamin A supplementation. J Nutr. 2002;132(9 suppl):2902S-2906S
7. Myhre AM, Carlsen MH, Bohn SK, Wold HL, Laake P, Blomhoff R. Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations. Am J Clin Nutr. 2003;78:1152-1159
8. Hartmann S, Froescheis O, Ringenbach F, et al. Determination of retinol and retinyl esters in human plasma by high-performance liquid chromatography with automated column switching and ultraviolet detection. J Chromatogr B Biomed Sci Appl. 2001;751:265-275
9. Lockitch G, Halstead AC, Wadsworth L, Quigley G, Reston L, Jacobson B. Age- and sex-specific pediatric reference intervals and correlations for zinc, copper, selenium, iron, vitamins A and E, and related proteins. Clin Chem. 1988;34:1625-1628
10. Ballew C, Bowman BA, Russell RM, Sowell AL, Gillespie C; National Health and Nutrition Examination Survey (NHANES III). Serum retinyl esters are not associated with biochemical markers of liver dysfunction in adult participants in the third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Am J Clin Nutr. 2001;73:934-940
11. de Francisco A, Chakraborty J, Chowdhury HR, et al. Acute toxicity of vitamin A given with vaccines in infancy. Lancet. 1993;342:526-527
12. Florentino RF, Tanchoco CC, Ramos AC, et al. Tolerance of preschoolers to two dosage strengths of vitamin A preparation. Am J Clin Nutr. 1990;52:694-700
13. Macapinlac MP, Olson JA. A lethal hypervitaminosis A syndrome in young monkeys (Macacus fascicularis) following a single intramuscular dose of a water-miscible preparation containing vitamins A, D2 and E. Int J Vitam Nutr Res. 1981;51:331-341
14. Blomhoff R, Green MH, Green JB, Berg T, Norum KR. Vitamin A metabolism: new perspectives on absorption, transport, and storage. Physiol Rev. 1991;71:951-990
15. Reinersdorff DV, Bush E, Liberato DJ. Plasma kinetics of vitamin A in humans after a single oral dose of [8,9,19 -13C]retinyl palmitate. J Lipid Res. 1996;37:1875-1885
16. Tang G, Qin J, Dolnikowski GG, Russell RM. Short-term (intestinal) and long-term (postintestinal) conversion of betacarotene to retinol in adults as assessed by a stable-isotope reference method. Am J Clin Nutr. 2003;78:259-266
17. Zeghoud F, Ben-Mekhbi H, Djeghri N, Garabedian M. Vitamin D prophylaxis during infancy: comparison of the long-term effects of three intermittent doses (15, 5, or 2.5 mg) on 25-hydroxyvitamin D concentrations. Am J Clin Nutr. 1994;60:393-396
18. 2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89:5387-5391
19. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Magnesium, Phosphorus, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997
20. Hawton K, Simkin S, Deeks J, et al. UK legislation on analgesic packs: before and after study of long term effect on poisonings [published correction appears in BMJ. 2004;329:1159]. BMJ. 2004;329:1076