Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro

Molecular Immunology

Volumn 45, Issue 6, 2008, Pages 1761-1766

  Wagner, Christof ^a,b   Stegmaier, Sabine ^a   Hänsch, Gertrud Maria ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNFALLKRANKENHAUS BERLIN   (Germany)

Author keywords

CD34+ stem cell; Cytotoxicity; Granzyme B; HL 60; Polymorphonuclear neutrophils; U937

Indexed keywords

GRANZYME B; PERFORIN;

ARTICLE; BONE MARROW CELL; CD34 SELECTION; CELL GRANULE; CELL LINE; CELL STRAIN HL 60; CELL STRAIN U937; CYTOTOXIC T LYMPHOCYTE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NATURAL KILLER CELL; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, CD34; CELLS, CULTURED; CYTOPLASMIC GRANULES; GRANZYMES; HUMANS; KILLER CELLS, NATURAL; MYELOID CELLS; NEUTROPHILS; STEM CELLS;

EID: 38949142647     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.09.033     Document Type: Article

References (32)

1. Berthou C., Marolleau J.P., Lafaurie C., Soulie A., Dal-Cortivo L., Bourge J.P., Benbunan M., and Sasportes M. Granzyme B and perforin lytic proteins are expressed in CD34+ peripheral blood progenitor cells mobilized by chemotherapy and granulocyte colony stimulating factor. Blood 86 (1995) 3500-3506
2. Borregaard N., and Cowland J. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89 (1997) 3503-3521
3. Bruno A.P., Lautier D., d'Orgeix A.T., Laurent G., and Quillet-Mary A. Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perform. Blood 96 (2000) 1914-1920
4. Buzza M.S., Zamura L., Sun J., Bird C.H., Smith A.L., Trapani J.A., Froelich C.J., Nice E.C., and Bird P.I. Extracellular matrix remodelling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J. Biol. Chem. 280 (2005) 23549-23558
5. Costain D.J., Guha A.K., Liwski R.S., and Lee T.D.G. Murine hypodense eosinophils induce tumour cell apoptosis by a granzyme B-dependent mechanism. Cancer Immunol. Immunother. 50 (2001) 293-299
6. Cowland J.B., and Borregard N. The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules. J. Leukoc. Biol. 66 (1999) 989-995
7. Egesten A., Breton-Gorius J., Guichard J., Gulberg U., and Olsson I. The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidas, cathepsin G, elastase, proteinase 3 and bactericidal/permeability increasing protein. Blood 83 (1994) 2985-2994
8. Froelich C.J., Zhang X., Turbov J., Hudig D., Winkler U., and Hanna W.L. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J. Immunol. 151 (1993) 7161-7171
9. Gale R.P., and Zighelboim J. Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity. J. Immunol. 114 (1975) 1047-1051
10. Graziano R.F., Bail E.D., and Fanger M.W. The expression and modulation of human myeloid-specifc antigens during differentiation of the HL-60 cell line. Blood 61 (1983) 1215-1221
11. Grossmann W.J., and Ley T.J. Granzyme A and B are not expressed in human neutrophils [letter]. Blood 104 (2004) 907
12. Grossmann W.J., Verbsky J.W., Tollefsen B.L., Kemper C., Atkinson J.P., and Ley T.J. Differential expression of granzyme A and granzyme B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104 (2004) 2840-2848
13. Hino M., Suzuki K., Yamani T., Sakai N., Kurota H., Koh K.R., Ohta K., Hato F., Kitagawa S., and Tatsumi N. Ex vivo expansion of mature human neutrophils with normal function from purified peripheral blood CD34+ haematopoietic progenitor cells. Br. J. Haemtatol. 109 (2000) 314-321
14. Hochegger K., Eller P., and Rosenkranz A.R. Granzyme A: an additional weapon of polymorphonuclear neutrophils in innate immunity?[letter]. Blood 103 (2004) 1176
15. Hochegger K., Wagner C., Rosenkranz A., and Hänsch G.M. Polymorphonuclear neutrophils express granzyme A, granzyme B, and perforin: no doubt about it [letter]. Blood 104 (2004) 907-908
16. Hochegger K., Eller P., Huber J.M., Bernhard D., Mayer G., Zlabinger G.J., and Rosenkranz A.R. Expression of granzmye A in human polymorphonuclear neutrophils. Immunology 121 (2007) 166-173
17. Kjeldsen L., Sengelov H., Lollike K., Nielsen M.H., and Borregaard N. Isolation and characterization of gelatinase granules from human neutrophils. Blood 83 (1994) 1640-1649
18. Lettau M., Schmidt H., Kabelitz D., and Janssen O. Secretory lysosomes and their cargo in T and NK cells. Immunol. Lett. 108 (2007) 10-19
19. Martin P., Wallich R., Pardo J., Müllbacher A., Munder M., Modolell M., and Simon M. Quiescent and activated mouse granulocytes do not express granzyme A and granzyme B or perforin: similarities or differences with human polymorphonuclear leukocytes?. Blood 106 (2005) 2871-2878
20. Metkar S.S., and Froelich C.J. Human neutrophils lack granzyme A, granzyme B, and perforin [letter]. Blood 104 (2004) 905-906
21. Nauseef W.M. Neutrophil granules: heterogeneity of their contents reflects targeting by time. J. Leukoc. Biol. 66 (1999) 867-868
22. Oren A., and Taylor J.M. The subcellular localization of defensins and myeloperoxidase in human neutrophils: immunocytochemical evidence for azurophil granule heterogeneity. J. Lab. Clin. Med. 125 (1995) 340-347
23. Rice W.G., Ganz T., Kinkade J.M., Selsted M., Lehrer R.I., and Parmley R.T. Defensin-rich dense granules of human neutrophils. Blood 700 (1987) 757-765
24. Rissoan M.C., Duhen T., Bridon J.-M., Bendriss-Vermare N., Peronne C., de Saint Vis B., and Bates E. Substractive hybridization reveals the expression of immunoglobulin transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood 100 (2002) 3295-3303
25. Russell J.H., and Ley T. Lymphocyte-mediated cytotoxicity. Ann. Rev. Immunol. 20 (2002) 323-370
26. Theilgaard-Mönch K., Jacobsen L.C., Borup R., Rasmussen T., Bjerregard M.D., Nielsen F.C., Cowland J., and Borregaard N. The transcriptional program of terminal granulocyte differentiation. Blood 105 (2005) 1785-1796
27. Tordjmann T., Soulie A., Guettier C., Berthou C., Beaugrand M., and Sasportes M. Perforin and granzyme expression during chronic viral and autoimmune hepatitis. Liver 18 (1998) 391-397
28. Trapani J.A. Granzmyes: a family of lymphocyte granule serine proteases. Genome Biol. 2 (2001) Reviews 3014
29. Tschopp C.M., Spiegl N., Didichenko S., Lutmann W., Julius P., Virchow J.C., Hack C.E., and Dahinden C.A. Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood 108 (2006) 2290-2299
30. Wagner C., Iking-Konert C., Denefleh B., Stegmaier S., Hug F., and Hänsch G.M. Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils. Blood 103 (2004) 1099-1104
31. Witko-Sarsat V., Cramer E.M., Hieblot C., Guichard J., Nusbaum P., Lopes S., Lesavre P., and Halbwachs-Mecarelli L. Presence of proteinase 3 in secretory vesicles: evidence for a novel highly mobilizable intracellular pool distinct from azurophil granules. Blood 94 (1999) 2487-2496
32. Xu S.X., Wang S., Wang J.P., Mills G.B., Zhou Y., and Xu H.-J. Expression of endogenous granzyme B in a subset of human primary carcinoma. Br. J. Cancer 89 (2003) 135-139