Expression of granzyme A in human polymorphonuclear neutrophils

Immunology

Volumn 121, Issue 2, 2007, Pages 166-173

  Hochegger, Kathrin ^a   Eller, Philipp ^a   Huber, Julia M ^a   Bernhard, David ^a   Mayer, Gert ^a   Zlabinger, Gerhard J ^b   Rosenkranz, Alexander R ^a,c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Div of Nephrology and Dialysis   (Austria)

Author keywords

Granzyme; Neutrophils; Phagocytosis; Subcellular fractionation

Indexed keywords

CUPROPHANE; GRANZYME A; PEROXIDASE;

ARTICLE; BIOCOMPATIBILITY; CELL FRACTIONATION; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DIALYSIS MEMBRANE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; ESCHERICHIA COLI; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GRANULE CELL; HUMAN; HUMAN CELL; INTERCELLULAR SPACE; NEUTROPHIL; NORMAL HUMAN; OPSONIZATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMYELOCYTE; QUANTITATIVE ANALYSIS; RNA TRANSLATION; UPREGULATION; WESTERN BLOTTING;

CELL FRACTIONATION; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRANZYMES; HL-60 CELLS; HUMANS; NEUTROPHILS; PHAGOCYTOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCELLULAR FRACTIONS; UP-REGULATION;

EID: 34247510560     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02551.x     Document Type: Article

References (24)

1. Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 2003 3 : 361 70.
2. Irmler M, Hertig S, MacDonald HR, Sadoul R, Becherer JD, Proudfoot A, Solari R, Tschopp J. Granzyme A is an interleukin 1 beta-converting enzyme. J Exp Med 1995 181 : 1917 22.
3. Sower LE, Froelich CJ, Allegretto N, Rose PM, Hanna WD, Klimpel GR. Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol 1996 156 : 2585 90.
4. Suidan HS, Clemetson KJ, Brown-Luedi M, Niclou SP, Clemetson JM, Tschopp J, Monard D. The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin. Biochem J 1996 315 : 939 45.
5. Suidan HS, Bouvier J, Schaerer E, Stone SR, Monard D, Tschopp J. Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes. Proc Natl Acad Sci USA 1994 91 : 8112 6.
6. Lieberman J, Fan Z. Nuclear war: the granzyme A-bomb. Curr Opin Immunol 2003 15 : 553 9.
7. Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol 2003 4 : 145 53.
8. Faurschou M, Borregaard N. Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 2003 5 : 1317 27.
9. Kobayashi S, Voyich J, Buhl C, Stahl R, DeLeo F. Global changes in gene expression by human polymorphonuclear leukocytes during receptor-medaited phagocytosis: cell fate is regulated at the level of gene expression. Proc Natl Acad Sci USA 2002 99 : 6901 6.
10. Wagner C, Iking-Konert C, Denefleh B, Stegmaier S, Hug F, Hansch GM. Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils. Blood 2004 103 : 1099 104.
11. Hochegger K, Eller P, Rosenkranz AR. Granzyme A: an additional weapon of human polymorphonuclear neutrophils (PMNs) in innate immunity? Blood 2004 103 : 1176.
12. Grossman WJ, Ley TJ. Granzymes A and B are not expressed in human neutrophils. Blood 2004 104 : 906 7 (author reply 907-8).
13. Metkar SS, Froelich CJ. Human neutrophils lack granzyme A, granzyme B, and perforin. Blood 2004 104 : 905 6 (author reply 907-8).
14. Tschopp CM, Spiegl N, Didichenko S, Lutmann W, Julius P, Virchow JC, Hack CE, Dahinden CA. Granzyme B, a novel mediator of allergic inflammation. Its induction and release in blood basophils and human asthma. Blood 2006 108 : 2290 9.
15. Rosenkranz AR, Kormoczi GF, Thalhammer F, Menzel EJ, Horl WH, Mayer G, Zlabinger GJ. Novel C5-dependent mechanism of neutrophil stimulation by bioincompatible dialyzer membranes. J Am Soc Nephrol 1999 10 : 128 35.
16. Sengelov H, Kjeldsen L, Diamond MS, Springer TA, Borregaard N. Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils. J Clin Invest 1993 92 : 1467 76.
17. Borregaard N, Miller LJ, Springer TA. Chemoattractant-regulated mobilization of a novel intracellular compartment in human neutrophils. Science 1987 237 : 1204 6.
18. Kjeldsen L, Sengelov H, Borregaard N. Subcellular fractionation of human neutrophils on Percoll density gradients. J Immunol Meth 1999 232 : 131 43.
19. Pulford KA, Erber WN, Crick JA, Olsson I, Micklem KJ, Gatter KC, Mason DY. Use of monoclonal antibody against human neutrophil elastase in normal and leukaemic myeloid cells. J Clin Pathol 1988 41 : 853 60.
20. Morgan JG, Pereira HA, Sukiennicki T, Spitznagel JK, Larrick JW. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. Adv Exp Med Biol 1991 305 : 89 96.
21. Martin P, Wallich R, Pardo J, Mullbacher A, Munder M, Modelell M, Simon MM. Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes? Blood 2005 106 : 2871 8.
22. Zhang B, Hirahashi J, Cullere X, Mayadas TN. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem 2003 278 : 28443 54.
23. Gabay JE, Almeida RP. Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin. Curr Opin Immunol 1993 5 : 97 102.
24. Udby L, Calafat J, Sorensen OE, Borregaard N, Kjeldsen L. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. J Leukoc Biol 2002 72 : 462 9.