메뉴 건너뛰기




Volumn 42, Issue 12, 2007, Pages 1227-1231

A new target for diabetes therapy: Advances in the research of glycogen synthase kinase-3 inhibitors

Author keywords

Diabetes; Glycogen synthase; Glycogen synthase kinase 3; Insulin resistance; Insulin signaling pathway

Indexed keywords

ENZYME INHIBITOR; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; INSULIN;

EID: 38949124424     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (23)
  • 1
    • 0020134901 scopus 로고
    • Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4, glycogen synthase kinase 5 from rabbit skeletal muscle [J]
    • Cohen P, Yellowlees D, Aitken A, et al. Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4, glycogen synthase kinase 5 from rabbit skeletal muscle [J]. Eur J Biochem, 1982,124:21-35.
    • (1982) Eur J Biochem , vol.124 , pp. 21-35
    • Cohen, P.1    Yellowlees, D.2    Aitken, A.3
  • 2
    • 0018218008 scopus 로고
    • How does insulin stimulate glycogen synthesis [J]
    • Cohen P, Nimmo HG, Proud CG. How does insulin stimulate glycogen synthesis [J]. Biochem Soc Symp, 1978,43:69-95.
    • (1978) Biochem Soc Symp , vol.43 , pp. 69-95
    • Cohen, P.1    Nimmo, H.G.2    Proud, C.G.3
  • 3
    • 33750867472 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3, an overview of an over-achieving protein kinase [J]
    • Kockeritz L, Doble B, Patel S, et al. Glycogen synthase kinase-3, an overview of an over-achieving protein kinase [J]. Curr Drug Targets, 2006,7:1377-1388.
    • (2006) Curr Drug Targets , vol.7 , pp. 1377-1388
    • Kockeritz, L.1    Doble, B.2    Patel, S.3
  • 4
    • 0026353474 scopus 로고
    • cDNA cloning and properties of glycogen synthase kinase-3 [J]
    • Woodgett JR. cDNA cloning and properties of glycogen synthase kinase-3 [J]. Methods Enzymol, 1991,200: 564-577.
    • (1991) Methods Enzymol , vol.200 , pp. 564-577
    • Woodgett, J.R.1
  • 5
    • 1642323740 scopus 로고    scopus 로고
    • Protein kinase inhibitors: Insights into drug design from structure [J]
    • Noble ME, Endicott JA, Johnson LN, et al. Protein kinase inhibitors: insights into drug design from structure [J]. Science, 2004,303:1800-1805.
    • (2004) Science , vol.303 , pp. 1800-1805
    • Noble, M.E.1    Endicott, J.A.2    Johnson, L.N.3
  • 6
    • 0035477020 scopus 로고    scopus 로고
    • GSK3 takes centre stage more than 20 years after its discovery [J]
    • Frame S, Cohen P. GSK3 takes centre stage more than 20 years after its discovery [J]. Biochem J, 2001,359: 1-16.
    • (2001) Biochem J , vol.359 , pp. 1-16
    • Frame, S.1    Cohen, P.2
  • 7
    • 19444371720 scopus 로고    scopus 로고
    • Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle [J]
    • Dokken BB, Sloniger JA, Henriksen EJ. Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle [J]. Am J Physiol Endocrinol Metab, 2005,288: 1188-1194.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. 1188-1194
    • Dokken, B.B.1    Sloniger, J.A.2    Henriksen, E.J.3
  • 8
    • 4544317872 scopus 로고    scopus 로고
    • Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3 on a muscle-specific promoter [J]
    • Pearce NJ, Arch JC, Clapham MP, et al. Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3 on a muscle-specific promoter [J]. Metabolism, 2004, 53: 1322-1330.
    • (2004) Metabolism , vol.53 , pp. 1322-1330
    • Pearce, N.J.1    Arch, J.C.2    Clapham, M.P.3
  • 9
    • 0035038729 scopus 로고    scopus 로고
    • Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression [J]
    • Lochhead PA, Coghlan M, Rice SQ, et al. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression [J]. Diabetes, 2001,50:937-946.
    • (2001) Diabetes , vol.50 , pp. 937-946
    • Lochhead, P.A.1    Coghlan, M.2    Rice, S.Q.3
  • 10
    • 27144504389 scopus 로고    scopus 로고
    • Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism [J]
    • Kim YB, Peroni OD, Aschenbach WG, et al. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism [J]. Mol Cell Biol, 2005,11:9713-9723.
    • (2005) Mol Cell Biol , vol.11 , pp. 9713-9723
    • Kim, Y.B.1    Peroni, O.D.2    Aschenbach, W.G.3
  • 11
    • 33750881942 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes [J]
    • Henriksen EJ, Dokken BB. Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes [J]. Curr Drug Targets, 2006,7:1435-1441.
    • (2006) Curr Drug Targets , vol.7 , pp. 1435-1441
    • Henriksen, E.J.1    Dokken, B.B.2
  • 12
    • 33745870108 scopus 로고    scopus 로고
    • Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in pre-diabetic obese Zucker rats [J]
    • Dokken BB, Henriksen EJ. Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in pre-diabetic obese Zucker rats [J]. Am J Physiol Endocrinol Metab, 2006,291: 209-213.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. 209-213
    • Dokken, B.B.1    Henriksen, E.J.2
  • 13
    • 15044356752 scopus 로고    scopus 로고
    • Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria [J]
    • Rao R, Zhang MZ, Zhao M, et al. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria [J]. Am J Physiol Renal Physiol, 2005,288:642-649.
    • (2005) Am J Physiol Renal Physiol , vol.288 , pp. 642-649
    • Rao, R.1    Zhang, M.Z.2    Zhao, M.3
  • 14
    • 33750902947 scopus 로고    scopus 로고
    • Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight-potential link to increased risk of diabetes [J]
    • Ozanne SE, Jensen CB, Tingey KJ, et al. Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight-potential link to increased risk of diabetes [J]. Diabetologia, 2006,49:2993-2999.
    • (2006) Diabetologia , vol.49 , pp. 2993-2999
    • Ozanne, S.E.1    Jensen, C.B.2    Tingey, K.J.3
  • 15
    • 38949108879 scopus 로고    scopus 로고
    • Inhibitor of glycogen synthase kinase (GSK) 3 promotes replication and survival of pancreatic beta cells [J]
    • Marcus G, Friedrich H. Inhibitor of glycogen synthase kinase (GSK) 3 promotes replication and survival of pancreatic beta cells [J]. J Biol Chem, 2007, 282: 12030-12037.
    • (2007) J Biol Chem , vol.282 , pp. 12030-12037
    • Marcus, G.1    Friedrich, H.2
  • 16
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats [J]
    • Gary WC, Kirk J, Werner R, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats [J]. Diabetes, 2002,51:2903-2910.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Gary, W.C.1    Kirk, J.2    Werner, R.3
  • 17
    • 0033776383 scopus 로고    scopus 로고
    • Selective small molecular inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and transcription [J]
    • Coghlan MP, Culbert AA, Cross DA. Selective small molecular inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and transcription [J]. Chem Biol, 2000,7;793-803.
    • (2000) Chem Biol , vol.7 , pp. 793-803
    • Coghlan, M.P.1    Culbert, A.A.2    Cross, D.A.3
  • 18
    • 0038811796 scopus 로고    scopus 로고
    • Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3 [J]
    • Batya P, Oksana K. Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3 [J]. J Pharmacol Exp Ther, 2003,305:974-980.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 974-980
    • Batya, P.1    Oksana, K.2
  • 19
    • 34547098724 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57 BL/6J mice [J]
    • Rao R, Hao CM, Redha R, et al. Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57 BL/6J mice [J]. Diabetologia, 2007,50:452-460.
    • (2007) Diabetologia , vol.50 , pp. 452-460
    • Rao, R.1    Hao, C.M.2    Redha, R.3
  • 20
    • 19944408613 scopus 로고    scopus 로고
    • Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 [J]
    • Murray JT, Campbell DG, Morrice N, et al. Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 [J]. Biochem J, 2004,384:477-488.
    • (2004) Biochem J , vol.384 , pp. 477-488
    • Murray, J.T.1    Campbell, D.G.2    Morrice, N.3
  • 21
    • 0036081578 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes [J]
    • Schwabe RF, Brenner DA. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes [J]. Liver Physiol, 2002,283: 204-211.
    • (2002) Liver Physiol , vol.283 , pp. 204-211
    • Schwabe, R.F.1    Brenner, D.A.2
  • 22
    • 0037303455 scopus 로고    scopus 로고
    • Enhancement of RNAi activity by improved siRNA duplexes [J]
    • Yu JY, Taylor J, DeRuiter SL, et al. Enhancement of RNAi activity by improved siRNA duplexes [J]. Mol Ther, 2003,7:228-236.
    • (2003) Mol Ther , vol.7 , pp. 228-236
    • Yu, J.Y.1    Taylor, J.2    DeRuiter, S.L.3
  • 23
    • 29244456731 scopus 로고    scopus 로고
    • Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: Molecular characterization in liver and muscle [J]
    • Kaidanovich-Beilin O, Eldar-Finkelman H. Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle [J]. J Pharmacol Exp Ther, 2006,316:17-24.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 17-24
    • Kaidanovich-Beilin, O.1    Eldar-Finkelman, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.