Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 3, 2008, Pages 961-966

  Depreter, Marianne G L ^a   Blair, Natalie F ^a   Gaskell, Terri L ^a   Nowell, Craig S ^a   Davern, Kathleen ^c   Pagliocca, Adelina ^a   Stenhouse, Frances H ^a   Farley, Alison M ^a   Fraser, Adrian ^a   Vrana, Jan ^a   Robertson, Kevin ^b   Morahan, Grant ^c   Tomlinson, Simon R ^a   Blackburn, C Clare ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Endoderm; Mesonephros; MTS24; Thymus development

Indexed keywords

CELL SURFACE MARKER; PLACENTA EXPRESSED TRANSCRIPT 1 PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; MTS24 PROTEIN, MOUSE; PLACENTA PROTEIN; PLET 1 PROTEIN, HUMAN; PLET 1 PROTEIN, MOUSE; PLET-1 PROTEIN, HUMAN; PLET-1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GASTRULATION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HOMEOSTASIS; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROSTATE EPITHELIUM; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING; STEM CELL; THYMUS; ANIMAL; CELL LINE; EMBRYO (ANATOMY); EPITHELIUM; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PANCREAS DUCT; PRENATAL DEVELOPMENT; TIME;

ANIMALS; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CELL LINE; EMBRYO, MAMMALIAN; EPITHELIAL CELLS; EPITHELIUM; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; PANCREATIC DUCTS; PREGNANCY PROTEINS; RNA, MESSENGER; STEM CELLS; THYMUS GLAND; TIME FACTORS;

EID: 38949110778     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711170105     Document Type: Article

References (35)

1. Miller JFAP (1961) Immunological function of the thymus. Lancet 2:748-749.
2. Anderson G, Jenkinson E (2001) Lymphostromal interactions in thymus development and function. Nat Rev Immunol 1:31-40.
3. Blackburn CC, et al. (2002) One for all and all for one: thymic epithelial stem cells and regeneration. Trends Immunol 23:391-395.
4. Kyewski B, Klein L (2006) A central role for central tolerance. Annu Rev Immunol 24:571-606.
5. Blackburn CC, et al. (1996) The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors. Proc Natl Acad Sci USA 93:5742-5746.
6. Bennett AR, et al. (2002) Identification and characterization of thymic epithelial progenitor cells. Immunity 16:803-814.
7. Gill J, Malin M, Hollander GA, Boyd R (2002) Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat Immunol 3:635-642.
8. Godfrey DI, Izon DJ, Tucek CL, Wilson TJ, Boyd RL (1990) The phenotypic heterogeneity of mouse thymic stromal cells. Immunology 70:66-74.
9. Gordon J, et al. (2004) Functional evidence for a single endodermal origin for the thymic epithelium. Nat Immunol 5:546-553.
10. Blackburn CC, Manley NR (2004) Developing a new paradigm for thymus organogenesis. Nat Rev Immunol 4:278-289.
11. Bleul CC, et al. (2006) Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441:992-996.
12. Rossi SW, Jenkinson WE, Anderson G, Jenkinson EJ (2006) Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441:988-991.
13. Rossi SW, et al. (2007) Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood 109:3803-3811.
14. Nijhof JG, et al. (2006) The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development 133:3027-3037.
15. Rochat A, Kobayashi K, Barrandon Y (1994) Location of stem cells of human hair follicles by clonal analysis. Cell 76:1063-1073.
16. Irizarry RA, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15.
17. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3, Article 3.
18. Smyth GK (2005) in Bioinformatics and Computational Biology Solutions Using R, Bioconductor, Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, eds (Springer, New York), pp 397-420.
19. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc B 57:289-300.
20. Zhao SH, et al. (2004) PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. Genomics 84:114-125.
21. Frankenberg S, Smith L, Greenfield A, Zernicka-Goetz M (2007) Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol 7:8.
22. Medvinsky A, Dzierzak E (1996) Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 86:897-906.
23. Tatefuji T, et al. (2004) Identification of the novel membrane-associated protein AgK114 on hamster keratinocytes recognized by a monoclonal antibody. K114. Biol Pharm Bull 27:1742-1749.
24. Stingl J, et al. (2006) Purification and unique properties of mammary epithelial stem cells. Nature 439:993-997.
25. Shackleton M, et al. (2006) Generation of a functional mammary gland from a single stem cell. Nature 439:84-88.
26. Taylor RA, et al. (2006) Formation of human prostate tissue from embryonic stem cells. Nat Methods 3:179-181.
27. Facchetti F, et al. (2007) Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions. Virchows Arch 451:669-680.
28. Grapin-Botton A (2005) Ductal cells of the pancreas. Int J Biochem Cell Biol 37:504-510.
29. Xu X, et al. (2008) Beta cell progenitors can be generated from endogenous progenitors in injured adult mouse pancreas. Cell, in press.
30. Hamazaki Y, et al. (2007) Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol 8:304-311.
31. Senoo M, Pinto F, Crum CP, McKeon F (2007) p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129:523-536.
32. Chambers I, et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643-655.
33. Gordon J, Bennett AR, Blackburn CC, Manley NR (2001) Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch. Mech Dev 103:141-143.
34. Goding J (1996) Monoclonal Antibodies: Principles and Practice (Academic, London).
35. Moore-Scott BA, Opoka R, Lin SJ, Kordich JJ, Wells JM (2007) Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to midgestation. Dev Dyn 236:1997-2003.