Structure-affinity relationship studies on benzotriazole derivatives binding to 5-HT receptor subtypes

European Journal of Medicinal Chemistry

Volumn 31, Issue 3, 1996, Pages 207-213

  Caliendo, G ^a   Greco, G ^a   Grieco, P ^a   Novellino, E ^b   Perissutti, E ^a   Santagada, V ^a   Barbarulo, D ^c   Esposito, E ^c   De Blasi, A ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

5HT receptor binding; Benzotriazole; SAR

Indexed keywords

2 [3 [4 (4 CHLOROPHENYL)PIPERAZINO]PROPYL]BENZOTRIAZOLE; BENZOTRIAZOLE DERIVATIVE; RECEPTOR SUBTYPE; RECOMBINANT PROTEIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; TRAZODONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

EID: 0029963036     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)89136-7     Document Type: Article

References (25)

1. Zifa E, Fillon G (1992) Pharmacol Rev 44, 401-458
2. Coppen AJ, Doogan DP (1988) J Clin Psychiatry 49, 4-11
3. Charney DS, Woods SW, Goodman WK, Heninger GR (1987) Psychopharmacology 92, 14-24
4. Zohar J, Insel TR, Zohar-Kadouch RC, Hill JL, Murphy DL (1988) Arch Gentile Psychiatry 45, 167-172
5. Peroutka SJ (1988) Annu Rev Neurosci 11, 45-60
6. Boess FG, Martin IL (1994) Neuropharmacology 33, 275-317
7. Glennon RA, Lucki I (1988) The Serotonin Receptors (Sanders-Bush E, ed), The Humana Press, Clifton, NJ, USA, 253-293
8. Kalkman HO, Soar J (1990) Eur J Pharmacol 191, 383-390
9. Bendotti C, Samanin R (1986) Eur J Pharmacol 158, 147-150
10. Lucki I, Ward HR, Frazer A (1989) J Pharmacol Exp Ther 249, 155-164
11. Kennett GA, Curzon G (1988) Psychopharmacology 96, 93-100
12. Kennett GA, Wood MD, Glen A et al (1994) Br J Pharmacol 11, 797-802
13. Goldstein JM, Litwin LC (1988) Fed Am Soc Exp Biol J 2, A1404
14. Julius D, Huang KN, Livelli TJ, Axel R, Jessell TM (1990) Proc Natl Acad Sci USA 87, 928-932
15. Caliendo G, Di Carlo R, Meli R et al (1993) Eur J Med Chem 28, 969-974
16. Caliendo G, Di Carlo R, Greco G, Meli R et al (1995) Eur J Med Chem 30, 77-84
17. Silvestrini B (1980) In: Trazodone, a New Broad-Spectrum Antidepressant (Gershon S, Rickels K, Silvestrini B, eds), Excerpta Medica, Amsterdam, 1-7
18. Mokrosz JL, Paluchowska MH, Chojnacka-Wójcik E et al (1994) J Med Chem 37, 2754-2760
19. Katritzky AR, Rachwal S, Rachwal B (1987) J Chem Soc Perkin Trans 2, 799-804
20. Cramer RD III, Patterson DE, Bunce JD (1988) J Am Chem Soc 110, 5959-5967
21. Free SM, Wilson JW (1964) J Med Chem 7, 395-399
22. Fujita T, Ban TJ (1971) J Med Chem 14, 148-152
23. Ismaiel AM, Arruda K, Teitler M, Glennon, RA (1995) J Med Chem 38, 1196-1202
24. Russo F, Romeo G, Guccione S, De Blasi A (1991) J Med Chem 34, 1850-1854
25. Cheng Y, Prusoff WH (1973) Biochem Pharmacol 22, 3099-3107