1,2,3-Triazolo[4,5-d]pyridazines. Part VI. New 1-substituted-4-amino derivatives and their affinity towards A1 and A(2A) adenosine receptors

Farmaco

Volumn 54, Issue 9, 1999, Pages 615-623

  Biagi, Giuliana ^a   Giorgi, Irene ^a   Livi, Oreste ^a   Manera, Clementina ^a   Scartoni, Valerio ^a   Betti, Laura ^b   Giannaccini, Gino ^b   Lucacchini, Antonio ^b  

^a UNIVERSITY OF PISA   (Italy)

^b Dipartmento di Biologia   (Italy)

Author keywords

1,2,3 Triazolo 4,5 d pyridazines; Adenosine receptor binding

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; PYRIDAZINE DERIVATIVE; TRIAZOLOPYRIDAZINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN;

EID: 0032824171     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(99)00072-5     Document Type: Article

References (19)

1. Biagi G., Giorgi I., Livi O., Scartoni V., Martini C., Tacchi P., Merlino S., Pasero M. 1,2,3-Triazolo[4,5-d]pyridazines. II. New derivatives tested on adenosine receptors. Farmaco. 49:1994;175-181.
2. Biagi G., Giorgi I., Livi O., Scartoni V., Lucacchini A., Senatore G., Barili P.L. 1,2,3-Triazolo[4,5-d]pyridazines. III. Synthesis of new 4-amino derivatives and their affinity toward adenosine receptors. Farmaco. 49:1994;357-362.
3. Biagi G., Giorgi I., Livi O., Scartoni V., Velo S., Martini C., Senatore G., Barili P.L. 1,2,3-Triazolo[4,5-d]pyridazines. IV. Preparation and adenosine receptor binding of new 4- and/or 7-amino derivatives. Farmaco. 50:1995;99-105.
4. Biagi G., Giorgi I., Livi O., Manera C., Scartoni V., Lucacchini A., Senatore G. 1,2,3-Triazolo[4,5-d]pyridazines. V. Preparation and adenosine receptor binding of new 4-amino derivatives. Farmaco. 51:1996;601-608.
5. 1 adenosine receptors. J. Med. Chem. 41:1998;668-673.
6. 2 receptors. IV. Farmaco. 49:1994;183-186.
7. 2 receptors. A comparison with 2-n-butyl analogous derivatives. V. Farmaco. 49:1994;187-191.
8. 2 receptors. A comparison with the corresponding 2-phenyl-9-benzyl-8-azaadenines. Farmaco. 50:1995;13-19.
9. 1 adenosine receptors. VII. Farmaco. 50:1995;659-667.
10. 1 adenosine receptor affinity. A comparison with the corresponding N(6)-substituted 2-phenyl-N(9)-benzyl-8-azaadenines. Farmaco. 51:1996;395-399.
11. 1 receptor and ligand molecular modeling. Drug Dev. Res. 28:1993;237-243.
12. Ried W., Laoutidis J. Synthesis neuer stickstoffreicher heterocyclen. Chem. Ztg. 114:1990;246-248.
13. Aubert T., Farnier M., Guilard R. New method for synthesis of isoindolinones and isoquinolines by condensation of iminophosphoranes with o-phthalaldehyde: reactions, mechanisms and structural study. Can. J. Chem. 68:1990;842-851.
14. Kreher R., Bergman U. Nitrogen eliminations by electrophiles - Part 9 - Investigations on the formation of cyclic N-diazonium ions. Tetrahedron Lett. 47:1976;4259-4262.
15. 2A adenosine receptor antagonists. Bioorg. Med. Chem. Lett. 4:1994;2539-2544.
16. Vorbruggen H., Krolikiewicz K. Silylation-amination of hydroxy N-heterocycles. Chem. Ber. 117:1984;1523-1541.
17. Andersen L., Nielsen F.E., Pedersen E.B. Synthesis of new 1,2,3-triazolo[4,5-d]pyridazine derivatives. Chem. Scr. 29:1989;45-49.
18. Biagi G., Giorgi I., Livi O., Manera C., Scartoni V. 1,2,3-Triazolo[4,5-d]-1,2,4-triazolo[4,3-b]pyridazines. J. Heterocycl. Chem. 34:1997;65-69.
19. 1 adenosine receptor. An evaluation of the binding free-energy with ligands. Drug Des. Discovery. 15:1998;149-156.