Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine

Pediatric Research

Volumn 62, Issue 5, 2007, Pages 570-575

  Kajanne, Risto ^a   Leppä, Sirpa ^a,c   Luukkainen, Päivi ^b   Ustinov, Jarkko ^b   Thiel, Alexandra ^a   Ristimäki, Ari ^a,c   Miettinen, Päivi J ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; HYDROCORTISONE; INDOMETACIN; PROSTAGLANDIN E2; EPIDERMAL GROWTH FACTOR; HER1 PROTEIN, HUMAN; MESSENGER RNA; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN; PTGS2 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTESTINE CELL; INTESTINE PERFORATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE MUCOSA; UPREGULATION; ANIMAL; CELL LINE; CELL MOTION; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE MUTANT; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; SMALL INTESTINE;

ANIMALS; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; ENTEROCYTES; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROCORTISONE; INDOMETHACIN; INTESTINE, SMALL; MICE; MICE, KNOCKOUT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 38849199379     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/PDR.0b013e318155ac3b     Document Type: Article

References (35)

1. Watterberg KL, Gerdes JS, Cole CH, Aucott SW, Thilo EH, Mammel MC, Couser RJ, Garland JS, Rozycki HJ, Leach CL, Backstrom C, Shaffer ML 2004 Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial. Pediatrics 114:1649-1657
2. Attridge JT, Clark R, Walker MW, Gordon PV 2006 New insights into spontaneous intestinal perforation using a national data set: (2) two populations of patients with perforations. J Perinatol 26:185-188
3. Dollberg S, Lusky A, Reichman B 2005 Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study. J Pediatr Gastroenterol Nutr 40:184-188
4. Fujii AM, Brown E, Mirochnick M, O'Brien S, Kaufman G 2002 Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. J Perinatol 22:535-540
5. Grosfeld JL, Chaet M, Molinari F, Engle W, Engum SA, West KW, Rescorla FJ, Scherer LR 3rd 1996 Increased risk of necrotizing enterocolitis in premature infants with patent ductus arteriosus treated with indomethacin. Ann Surg 224:350-355
6. Miettinen PJ 1993 Transforming growth factor-alpha and epidermal growth factor in human fetal gastrointestinal tract. Pediatr Res 33:481-486
7. Wong WM, Wright NA 1999 Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. JPEN J Parenter Enteral Nutr 23:S83-S88
8. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen R, Werb Z, Derynck R 1995 Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337-341
9. Dvorak B, Halpern MD, Holubec H, Williams CS, McWilliam DL, Dominguez JA, Stepankova R, Payne CM, McCuskey RS 2002 Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 282:G156-G164
10. Clark JA, Doelle SM, Halpern MD, Saunders TA, Holubec H, Dvorak K, Boitano SA, Dvorak B 2006 Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of epidermal growth factor treatment. Am J Physiol Gastrointest Liver Physiol 291:G938-G949
11. Leppa S, Saffrich R, Ansorge W, Bohmann D 1998 Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J 17:4404-4413
12. Abud HE, Watson N, Heath JK 2005 Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp Cell Res 303:252-262
13. Sheng G, Bernabe KQ, Guo J, Warner BW 2006 Epidermal growth factor receptor-mediated proliferation of enterocytes requires p21waf1/cip1 expression. Gastroenterology 131:153-164
14. Salamanca CM, Maines-Bandiera SL, Leung PC, Hu YL, Auersperg N 2004 Effects of epidermal growth factor/hydrocortisone on the growth and differentiation of human ovarian surface epithelium. J Soc Gynecol Investig 11:241-251
15. Szabo IL, Pai R, Jones MK, Ehring GR, Kawanaka H, Tarnawski AS 2002 Indomethacin delays gastric restitution: association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers. Exp Biol Med (Maywood) 227:412-424
16. Arsenault P, Menard D 1985 Influence of hydrocortisone on human fetal small intestine in organ culture. J Pediatr Gastroenterol Nutr 4:893-901
17. Ménard D, Arsenault P, Pothier P 1988 Biologic effects of epidermal growth factor in human fetal jejunum. Gastroenterology 94:656-663
18. Kajino H, Chen YQ, Chemtob S, Waleh N, Koch CJ, Clyman RI 2000 Tissue hypoxia inhibits prostaglandin and nitric oxide production and prevents ductus arteriosus reopening. Am J Physiol Regul Integr Comp Physiol 279:R278-R286
19. Bayer BM, Beaven MA 1979 Evidence that indomethacin reversibly inhibits cell growth in the G1 phase of the cell cycle. Biochem Pharmacol 28:441-443
20. Mammen JM, Matthews JB 2003 Mucosal repair in the gastrointestinal tract. Crit Care Med 31:S532-S537
21. Wells A, Harms B, Iwabu A, Koo L, Smith K, Griffith L, Lauffenburger DA 2006 Motility signaled from the EGF receptor and related systems. Methods Mol Biol 327:159-177
22. Uribe A, Johansson C 1988 Initial kinetic changes of prostaglandin E2-induced hyperplasia of the rat small intestinal epithelium occur in the villous compartments. Gastroenterology 94:1335-1342
23. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, Tarnawski AS 2002 Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8:289-293
24. Ali S, El-Rayes BF, Sarkar FH, Philip PA 2005 Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Mol Cancer Ther 4:1943-1951
25. Bailey JM, Makheja AN, Pash J, Verma M 1988 Corticosteroids suppress cyclooxygenase messenger RNA levels and prostanoid synthesis in cultured vascular cells. Biochem Biophys Res Commun 157:1159-1163
26. Elder JB, Ganguli PC, Gillespie IE, Delamore WI, Gregory H 1975 Effect of urogastrone in the Zollinger-Ellison syndrome. Lancet 2:424-427
27. Gordon PV, Price WA, Stiles AD, Rutledge JC 2001 Early postnatal dexamethasone diminishes transforming growth factor alpha localization within the ileal muscularis propria of newborn mice and extremely low-birth-weight infants. Pediatr Dev Pathol 4:532-537
28. Warner BW, Erwin CR 2006 Critical roles for EGF receptor signaling during resection-induced intestinal adaptation. J Pediatr Gastroenterol Nutr 43:S68-S73
29. Bernal NP, Stehr W, Coyle R, Erwin CR, Warner BW 2006 Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130:412-423
30. Sigalet DL, Martin GR, Butzner JD, Buret A, Meddings JB 2005 A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome. J Pediatr Surg 40:763-768
31. Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, Williams CS, Payne CM, Dvorak B 2005 Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 288:G755-G762
32. Walker-Smith JA, Phillips AD, Walford N, Gregory H, Fitzgerald JD, MacCullagh K, Wright NA 1985 Intravenous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital microvillous atrophy. Lancet 2:1239-1240
33. Sullivan PB, Brueton MJ, Tabara ZB, Goodlad RA, Lee CY, Wright NA 1991 Epidermal growth factor in necrotising enteritis. Lancet 338:53-54
34. Scott SM, Buenaflor GG, Orth DN 1989 Immunoreactive human epidermal growth factor concentration in amniotic fluid, umbilical artery and vein, serum, and placenta in full-term and preterm infants. Biol Neonate 56:246-251
35. Ng PC, Lee CH, Lam CW, Ma KC, Fok TF, Chan IH, Wong E 2004 Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 89:F119-F126