Epidermal Growth Factor Receptor-Mediated Proliferation of Enterocytes Requires p21waf1/cip1 Expression

Gastroenterology

Volumn 131, Issue 1, 2006, Pages 153-164

  Sheng, George ^a,b   Bernabe, Kathryn Q ^b   Guo, Jun ^b   Warner, Brad W ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; EPITHELIUM CELL; GENE CONSTRUCT; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTESTINE CELL; INTESTINE RESECTION; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

EID: 33745760717     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.05.007     Document Type: Article

References (42)

1. Williamson R.C. Intestinal adaptation. Structural, functional and cytokinetic changes. N Engl J Med 298 (1978) 1393-1402
2. Urban E., and Weser E. Intestinal adaptation to bowel resection. Adv Int Med 26 (1980) 265-291
3. O'Brien D.P., Nelson L.A., Huang F.S., and Warner B.W. Intestinal adaptation. structure, function, and regulation. Semin Pediatr Surg 10 (2001) 56-64
4. Stern L.E., Erwin C.R., O'Brien D.P., Huang F., and Warner B.W. Epidermal growth factor is critical for intestinal adaptation following small bowel resection. Microsc Res Tech 51 (2000) 138-148
5. kip1 during the adaptation response to massive intestinal resection. Am J Physiol Gastrointest Liver Physiol 290 (2006) G933-G941
6. Stern L.E., Falcone Jr. R.A., Kemp C.J., Erwin C.R., and Warner B.W. p21 (WAF1/CIP1) is required for the mitogenic response to intestinal resection. J Surg Res 90 (2000) 45-50
7. Cheng M., Olivier P., Diehl J.A., Fero M., Roussel M.F., Roberts J.M., and Sherr C.J. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of Cyclin D-dependent kinases in murine fibroblasts. EMBO J 18 (1999) 1571-1583
8. Harper J.W., Adami G.R., Wei N., Keyomarsi K., and Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 Cyclin-dependent kinases. Cell 75 (1993) 805-816
9. Wilson J.W., Pritchard D.M., Hickman J.A., and Potten C.S. Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium. apoptosis and cell cycle arrest. Am J Pathol 153 (1998) 899-909
10. Gartel A.L., and Tyner A.L. Transcriptional regulation of the p21(WAF1/CIP1) gene. Exp Cell Res 246 (1999) 280-289
11. Woods D., Parry D., Cherwinski H., Bosch E., Lees E., and McMahon M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17 (1997) 5598-5611
12. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103 (2000) 211-225
13. kip1 in enterocyte differentiation, proliferation, and migration. Surgery 138 (2005) 187-194
14. Erwin C.R., Helmrath M.A., Shin C.E., Falcone Jr. R.A., Stern L.E., and Warner B.W. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol 277 (1999) G533-G540
15. Luetteke N.C., Phillips H.K., Qiu T.H., Copeland N.G., Earp H.S., Jenkins N.A., and Lee D.C. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8 (1994) 399-413
16. Fowler K.J., Walker F., Alexander W., Hibbs M.L., Nice E.C., Bohmer R.M., Mann G.B., Thumwood C., Maglitto R., Danks J.A., et al. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci U S A 92 (1995) 1465-1469
17. Helmrath M.A., Erwin C.R., and Warner B.W. A defective EGF receptor in waved-2 mice attenuates intestinal adaptation. J Surg Res 69 (1997) 76-80
18. Helmrath M.A., VanderKolk W.E., Can G., Erwin C.R., and Warner B.W. Intestinal adaptation following massive small bowel resection in the mouse. J Am Coll Surg 183 (1996) 441-449
19. Quaroni A., and May R.J. Establishment and characterizaton of intestinal epithelial cell cultures. Methods Cell Biol 21B (1980) 403-427
20. Kirkland S.C. Dome formation by a human colonic adenocarcinoma cell line (HCA-7). Cancer Res 45 (1985) 3790-3795
21. Kirkland S.C., Henderson K., Liu D., and Pignatelli M. Organisation and gel contraction by human colonic carcinoma (HCA-7) sublines grown in 3-dimensional collagen gel. Int J Cancer 60 (1995) 877-882
22. Michieli P., Chedid M., Lin D., Pierce J.H., Mercer W.E., and Givol D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54 (1994) 3391-3395
23. Fan Z., Lu Y., Wu X., DeBlasio A., Koff A., and Mendelsohn J. Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. J Cell Biol 131 (1995) 235-242
24. Johannessen L.E., Knardal S.L., and Madshus I.H. Epidermal growth factor increases the level of the Cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein. Biochem J 337 (1999) 599-606
25. Liu Z.M., and Huang H.S. As(2)O(3)-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21(WAF1/CIP1) expression in human epidermoid carcinoma A431 cells. Cell Signal 18 (2006) 244-255
26. Deng C., Zhang P., Harper J.W., Elledge S.J., and Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82 (1995) 675-684
27. Yang W., Velcich A., Lozonschi I., Liang J., Nicholas C., Zhuang M., Bancroft L., and Augenlicht L.H. Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. Am J Pathol 166 (2005) 1239-1246
28. Yang W.C., Mathew J., Velcich A., Edelmann W., Kucherlapati R., Lipkin M., Yang K., and Augenlicht L.H. Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. Cancer Res 61 (2001) 565-569
29. Boucher M.J., Jean D., Vezina A., and Rivard N. Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 286 (2004) G736-G746
30. Garrington T.P., and Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11 (1999) 211-218
31. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
32. Reddy K.B., Keshamouni V.G., and Chen Y.Q. The level of tyrosine kinase activity regulates the expression of p21/WAF1 in cancer cells. Int J Oncol 15 (1999) 301-306
33. Leaman D.W., Pisharody S., Flickinger T.W., Commane M.A., Schlessinger J., Kerr I.M., Levy D.E., and Stark G.R. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cell Biol 16 (1996) 369-375
34. Chin Y.E., Kitagawa M., Su W.C., You Z.H., Iwamoto Y., and Fu X.Y. Cell growth arrest and induction of Cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 272 (1996) 719-722
35. Johnson L.R., McCormack S.A., Yang C.H., Pfeffer S.R., and Pfeffer L.M. EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells. Am J Physiol 276 (1999) C419-C425
36. Stehr W., Bernal N.P., Bernabe K.Q., Erwin C.R., and Warner B.W. Absent STAT 1 expression perturbs adaptation and apoptosis after massive intestinal resection. J Pediatr Surg 41 (2006) 713-718
37. Biggs J.R., Kudlow J.E., and Kraft A.S. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. J Biol Chem 271 (1996) 901-906
38. Somasundaram K., Zhang H., Zeng Y.X., Houvras Y., Peng Y., Zhang H., Wu G.S., Licht J.D., Weber B.L., and el-Deiry W.S. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature 389 (1997) 187-190
39. Moustakas A., and Kardassis D. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci U S A 95 (1998) 6733-6738
40. Guo J., Sheng G., and Warner B.W. Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells. J Biol Chem 280 (2005) 35992-35998
41. Deschenes C., Alvarez L., Lizotte M.E., Vezina A., and Rivard N. The nucleocytoplasmic shuttling of E2F4 is involved in the regulation of human intestinal epithelial cell proliferation and differentiation. J Cell Physiol 199 (2004) 262-273
42. Decesse J.T., Medjkane S., Datto M.B., and Cremisi C.E. RB regulates transcription of the p21/WAF1/CIP1 gene. Oncogene 20 (2001) 962-971